{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:58:50Z","timestamp":1760234330584,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.<\/jats:p>","DOI":"10.3390\/molecules26092650","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T21:35:39Z","timestamp":1619904939000},"page":"2650","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution"],"prefix":"10.3390","volume":"26","author":[{"given":"Vusani","family":"Mandiwana","sequence":"first","affiliation":[{"name":"Centre for Nanostructures and Advanced Materials CeNAM, Chemical Cluster, Advanced Functional Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa"},{"name":"Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom 2520, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lonji","family":"Kalombo","sequence":"additional","affiliation":[{"name":"Centre for Nanostructures and Advanced Materials CeNAM, Chemical Cluster, Advanced Functional Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Hayeshi","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom 2520, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0794-3012","authenticated-orcid":false,"given":"Jan Rijn","family":"Zeevaart","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom 2520, South Africa"},{"name":"Radiochemistry, South African Nuclear Energy Corporation (Necsa), Pelindaba, Brits 0240, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-7324","authenticated-orcid":false,"given":"Thomas","family":"Ebenhan","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom 2520, South Africa"},{"name":"Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria 0001, South Africa"},{"name":"Preclinical Imaging Facility, NuMeRI, Pelindaba, Brits 0242, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"ref_1","first-page":"39","article-title":"Review on microemulsion as futuristic drug delivery","volume":"5","author":"Muzaffar","year":"2013","journal-title":"Int. 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