{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:41:37Z","timestamp":1789810897536,"version":"4.0.1"},"reference-count":79,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771322"],"award-info":[{"award-number":["31771322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7212121"],"award-info":[{"award-number":["7212121"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major R &amp; D Program of National Ministry of Science and Technology of China","award":["2018YFB1105504"],"award-info":[{"award-number":["2018YFB1105504"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The nervous system is a significant part of the human body, and peripheral nerve injury caused by trauma can cause various functional disorders. When the broken end defect is large and cannot be repaired by direct suture, small gap sutures of nerve conduits can effectively replace nerve transplantation and avoid the side effect of donor area disorders. There are many choices for nerve conduits, and natural materials and synthetic polymers have their advantages. Among them, the nerve scaffold should meet the requirements of good degradability, biocompatibility, promoting axon growth, supporting axon expansion and regeneration, and higher cell adhesion. Polymer biological scaffolds can change some shortcomings of raw materials by using electrospinning filling technology and surface modification technology to make them more suitable for nerve regeneration. Therefore, polymer scaffolds have a substantial prospect in the field of biomedicine in future. This paper reviews the application of nerve conduits in the field of repairing peripheral nerve injury, and we discuss the latest progress of materials and fabrication techniques of these polymer scaffolds.<\/jats:p>","DOI":"10.3390\/molecules26092712","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T22:51:42Z","timestamp":1620255102000},"page":"2712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Polymer Scaffolds for Biomedical Applications in Peripheral Nerve Reconstruction"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-8133","authenticated-orcid":false,"given":"Meng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Trauma, Peking University People\u2019s Hospital, Beijing 100083, China"},{"name":"Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ci","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma, Peking University People\u2019s Hospital, Beijing 100083, China"},{"name":"Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, School of Chemistry &amp; Biological Engineering, University of Science &amp; Technology Beijing, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma, Peking University People\u2019s Hospital, Beijing 100083, China"},{"name":"Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Xun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma, Peking University People\u2019s Hospital, Beijing 100083, China"},{"name":"Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing 100083, China"},{"name":"National Center for Trauma Medicine, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1016\/j.biomaterials.2012.06.002","article-title":"The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair","volume":"33","author":"Daly","year":"2012","journal-title":"Biomaterials"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/AAP.0000000000000185","article-title":"Neurologic Evaluation and Management of Perioperative Nerve Injury","volume":"40","author":"Watson","year":"2015","journal-title":"Reg. 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