{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:19:41Z","timestamp":1789579181381,"version":"build-2803163510"},"reference-count":156,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Leukemia is a leukocyte cancer that is characterized by anarchic growth of immature immune cells in the bone marrow, blood and spleen. There are many forms of leukemia, and the best course of therapy and the chance of a patient\u2019s survival depend on the type of leukemic disease. Different forms of drugs have been used to treat leukemia. Due to the adverse effects associated with such therapies and drug resistance, the search for safer and more effective drugs remains one of the most challenging areas of research. Thus, new therapeutic approaches are important to improving outcomes. Almost half of the drugs utilized nowadays in treating cancer are from natural products and their derivatives. Medicinal plants have proven to be an effective natural source of anti-leukemic drugs. The cytotoxicity and the mechanisms underlying the toxicity of these plants to leukemic cells and their isolated compounds were investigated. Effort has been made throughout this comprehensive review to highlight the recent developments and milestones achieved in leukemia therapies using plant-derived compounds and the crude extracts from various medicinal plants. Furthermore, the mechanisms of action of these plants are discussed.<\/jats:p>","DOI":"10.3390\/molecules26092741","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T10:06:12Z","timestamp":1620381972000},"page":"2741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Medicinal Plants with Anti-Leukemic Effects: A Review"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-6457","authenticated-orcid":false,"given":"Tahani","family":"Maher","sequence":"first","affiliation":[{"name":"Biotechnology Engineering Department, Kulliyyah of Engineering, International Islamic University, Malaysia (IIUM), P.O. Box 10, Gombak, Kuala Lumpur 50728, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raha","family":"Ahmad Raus","sequence":"additional","affiliation":[{"name":"Biotechnology Engineering Department, Kulliyyah of Engineering, International Islamic University, Malaysia (IIUM), P.O. Box 10, Gombak, Kuala Lumpur 50728, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-162X","authenticated-orcid":false,"given":"Djabir","family":"Daddiouaissa","sequence":"additional","affiliation":[{"name":"Biotechnology Engineering Department, Kulliyyah of Engineering, International Islamic University, Malaysia (IIUM), P.O. Box 10, Gombak, Kuala Lumpur 50728, Malaysia"},{"name":"International Institute for Halal Research and Training (INHART), Level 3, KICT Building, International Islamic University Malaysia (IIUM), Jalan Gombak, Kuala Lumpur 53100, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-2259","authenticated-orcid":false,"given":"Farah","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Biotechnology Engineering Department, Kulliyyah of Engineering, International Islamic University, Malaysia (IIUM), P.O. Box 10, Gombak, Kuala Lumpur 50728, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Suhana","family":"Adzhar","sequence":"additional","affiliation":[{"name":"Faculty of Industrial Sciences and Technology, Universiti Malaysia, Pekan Pahang, Kuantan 26600, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elda Surhaida","family":"Latif","sequence":"additional","affiliation":[{"name":"Centre for Toxicology and Health Risk Studies (CORE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-6482","authenticated-orcid":false,"given":"Ferid","family":"Abdulhafiz","sequence":"additional","affiliation":[{"name":"Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, Jeli, Kelantan 17600, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-8134","authenticated-orcid":false,"given":"Arifullah","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, Jeli, Kelantan 17600, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"ref_1","first-page":"556","article-title":"Antileukemia activity from root cultures of Vernonia amygdalina","volume":"3","author":"Khalafalla","year":"2009","journal-title":"J. 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