{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:57:57Z","timestamp":1791849477927,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011880","name":"Acad\u00e9mie de recherche et d'enseignement sup\u00e9rieur","doi-asserted-by":"publisher","award":["ARES-PRD2015 to M.F."],"award-info":[{"award-number":["ARES-PRD2015 to M.F."]}],"id":[{"id":"10.13039\/501100011880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Malaria remains one of the leading causes of death in sub-Saharan Africa, ranked in the top three infectious diseases in the world. Plants of the Eriosema genus have been reported to be used for the treatment of this disease, but scientific evidence is still missing for some of them. In the present study, the in vitro antiplasmodial activity of the crude extract and compounds from Eriosema montanum Baker f. roots were tested against the 3D7 strain of Plasmodium falciparum and revealed using the SYBR Green, a DNA intercalating compound. The cytotoxicity effect of the compounds on a human cancer cell line (THP-1) was assessed to determine their selectivity index. It was found that the crude extract of the plant displayed a significant antiplasmodial activity with an IC50 (\u00b5g\/mL) = 17.68 \u00b1 4.030 and a cytotoxic activity with a CC50 (\u00b5g\/mL) = 101.5 \u00b1 12.6, corresponding to a selective antiplasmodial activity of 5.7. Bioactivity-guided isolation of the major compounds of the roots\u2019 crude extract afforded seven compounds, including genistein, genistin and eucomic acid. Under our experimental conditions, using Artemisinin as a positive control, eucomic acid showed the best inhibitory activity against the P. falciparum 3D7, a well-known chloroquine-sensitive strain. The present results provide a referential basis to support the traditional use of Eriosema species in the treatment of malaria.<\/jats:p>","DOI":"10.3390\/molecules26092795","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T05:30:08Z","timestamp":1620624608000},"page":"2795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["In Vitro Antiplasmodial and Cytotoxic Activities of Compounds from the Roots of Eriosema montanum Baker f. (Fabaceae)"],"prefix":"10.3390","volume":"26","author":[{"given":"Jean Claude Didelot","family":"Tomani","sequence":"first","affiliation":[{"name":"School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali P.O. Box 3286, Rwanda"},{"name":"Department of Molecular Biology, Institute for Molecular Biology and Medicine, Universit\u00e9 Libre de Bruxelles, 6041 Gosselies, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-6640","authenticated-orcid":false,"given":"Olivier","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research on Medicines (CIRM), Laboratory of Pharmacognosy, University of Li\u00e8ge, B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4731-6497","authenticated-orcid":false,"given":"Alain","family":"Nyirimigabo","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali P.O. Box 3286, Rwanda"},{"name":"Centre for Interdisciplinary Research on Medicines (CIRM), Laboratory of Pharmacognosy, University of Li\u00e8ge, B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-9383","authenticated-orcid":false,"given":"William","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Institute for Molecular Biology and Medicine, Universit\u00e9 Libre de Bruxelles, 6041 Gosselies, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alembert Tiabou","family":"Tchinda","sequence":"additional","affiliation":[{"name":"Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaound\u00e9 P.O. Box 13033, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Jansen","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research on Medicines (CIRM), Laboratory of Pharmacognosy, University of Li\u00e8ge, B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-6336","authenticated-orcid":false,"given":"Allison","family":"Ledoux","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research on Medicines (CIRM), Laboratory of Pharmacognosy, University of Li\u00e8ge, B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Jeanne","family":"Mukazayire","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali P.O. Box 3286, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Vanhamme","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Institute for Molecular Biology and Medicine, Universit\u00e9 Libre de Bruxelles, 6041 Gosselies, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-9990","authenticated-orcid":false,"given":"Michel","family":"Fr\u00e9d\u00e9rich","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research on Medicines (CIRM), Laboratory of Pharmacognosy, University of Li\u00e8ge, B36, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Muganga","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Kigali P.O. Box 3286, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1526-4431","authenticated-orcid":false,"given":"Jacob","family":"Souopgui","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Institute for Molecular Biology and Medicine, Universit\u00e9 Libre de Bruxelles, 6041 Gosselies, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"ref_1","unstructured":"WHO (2020). World Malaria Report, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2174\/1566524020666200207123253","article-title":"An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance","volume":"20","author":"Qian","year":"2020","journal-title":"Curr. Mol. 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