{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:48:29Z","timestamp":1778352509422,"version":"3.51.4"},"reference-count":57,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The synthesis of organometallic compounds with potential pharmacological activity has attracted the attention of many research groups, aiming to take advantage of aspects that the presence of the metal-carbon bond can bring to the design of new pharmaceutical drugs. In this context, we have gathered studies reported in the literature in which psychoactive benzodiazepine drugs were used as ligands in the preparation of organometallic and metal complexes and provide details on some of their biological effects. We also highlight that most commonly known benzodiazepine-based drugs display molecular features that allow the preparation of metallacycles via C-H activation. These organometallic compounds merit further attention regarding their potential biological effects, not only in terms of psychoactive drugs but also in the search for drug replacements, for example, for cancer treatments.<\/jats:p>","DOI":"10.3390\/molecules26092796","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T05:30:08Z","timestamp":1620624608000},"page":"2796","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Benzodiazepines: Drugs with Chemical Skeletons Suitable for the Preparation of Metallacycles with Potential Pharmacological Activity"],"prefix":"10.3390","volume":"26","author":[{"given":"Artur V.","family":"da Silva","sequence":"first","affiliation":[{"name":"Grupo de Cat\u00e1lise e Reatividade Qu\u00edmica, Instituto de Qu\u00edmica e Biotecnologia, Universidade Federal de Alagoas, Av. Lourival de Melo Mota, s\/n, Macei\u00f3\/AL 57072-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simoni M. P.","family":"Meneghetti","sequence":"additional","affiliation":[{"name":"Grupo de Cat\u00e1lise e Reatividade Qu\u00edmica, Instituto de Qu\u00edmica e Biotecnologia, Universidade Federal de Alagoas, Av. Lourival de Melo Mota, s\/n, Macei\u00f3\/AL 57072-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0722-8599","authenticated-orcid":false,"given":"Mario R.","family":"Meneghetti","sequence":"additional","affiliation":[{"name":"Grupo de Cat\u00e1lise e Reatividade Qu\u00edmica, Instituto de Qu\u00edmica e Biotecnologia, Universidade Federal de Alagoas, Av. Lourival de Melo Mota, s\/n, Macei\u00f3\/AL 57072-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e018956","DOI":"10.1136\/bmjopen-2017-018956","article-title":"Long-term benzodiazepine use in patients taking antidepressants in a public health setting in Brazil: A cross-sectional study","volume":"8","author":"Fulone","year":"2018","journal-title":"BMJ Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/pds.3951","article-title":"Trends in prescribing of sedative-hypnotic medications in the USA:1993\u20132010","volume":"25","author":"Kaufmann","year":"2016","journal-title":"Pharmacoepidemiol. 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