{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:11:37Z","timestamp":1770372697832,"version":"3.49.0"},"reference-count":65,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of National Economy, National Research Development and Innovation Office","award":["GINOP2.3.2-15-2016-00034"],"award-info":[{"award-number":["GINOP2.3.2-15-2016-00034"]}]},{"name":"Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund","award":["UNKP-20-3-SZTE-319 - New National Excellence Program"],"award-info":[{"award-number":["UNKP-20-3-SZTE-319 - New National Excellence Program"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Bismuth subnitrate is reported herein as a simple and efficient catalyst for the atom-economical synthesis of methyl ketones via Markovnikov-type alkyne hydration. Besides an effective batch process under reasonably mild conditions, a chemically intensified continuous flow protocol was also developed in a packed-bed system. The applicability of the methodologies was demonstrated through hydration of a diverse set of terminal acetylenes. By simply switching the reaction medium from methanol to methanol-d4, valuable trideuteromethyl ketones were also prepared. Due to the ready availability and nontoxicity of the heterogeneous catalyst, which eliminated the need for any special additives and\/or harmful reagents, the presented processes display significant advances in terms of practicality and sustainability.<\/jats:p>","DOI":"10.3390\/molecules26102864","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T22:46:14Z","timestamp":1620859574000},"page":"2864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions"],"prefix":"10.3390","volume":"26","author":[{"given":"Zsanett","family":"Sz\u00e9cs\u00e9nyi","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Chemistry, University of Szeged, Interdisciplinary Excellence Center, E\u00f6tv\u00f6s u. 6, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-5287","authenticated-orcid":false,"given":"Ferenc","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Chemistry, University of Szeged, Interdisciplinary Excellence Center, E\u00f6tv\u00f6s u. 6, H-6720 Szeged, Hungary"},{"name":"MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences, Interdisciplinary Excellence Center, E\u00f6tv\u00f6s u. 6, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-1744","authenticated-orcid":false,"given":"S\u00e1ndor B.","family":"\u00d6tv\u00f6s","sequence":"additional","affiliation":[{"name":"MTA-SZTE Stereochemistry Research Group, Hungarian Academy of Sciences, Interdisciplinary Excellence Center, E\u00f6tv\u00f6s u. 6, H-6720 Szeged, Hungary"},{"name":"Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1039\/C8GC01276H","article-title":"Key Green Chemistry research areas from a pharmaceutical manufacturers' perspective revisited","volume":"20","author":"Bryan","year":"2018","journal-title":"Green Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1021\/acs.chemrev.7b00571","article-title":"Green and Sustainable Solvents in Chemical Processes","volume":"118","author":"Clarke","year":"2018","journal-title":"Chem. 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