{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:41:18Z","timestamp":1787787678826,"version":"build-2784847793"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Institute for Health Sciences, Walailak University","award":["WU-IRG-63-016"],"award-info":[{"award-number":["WU-IRG-63-016"]}]},{"name":"Thailand Science Research and Innovation Fund","award":["WU-FF64102"],"award-info":[{"award-number":["WU-FF64102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The functional food market is growing with a compound annual growth rate of 7.9%. Thai food recipes use several kinds of herbs. Lemongrass, garlic, and turmeric are ingredients used in Thai curry paste. Essential oils released in the preparation step create the flavor and fragrance of the famous tom yum and massaman dishes. While the biological activities of these ingredients have been investigated, including the antioxidant, anti-inflammatory, and antimicrobial activities, there is still a lack of understanding regarding the responses to the essential oils of these plants. To investigate the effects of essential oil inhalation on the brain and mood responses, electroencephalography was carried out during the non-task resting state, and self-assessment of the mood state was performed. The essential oils were prepared in several dilutions in the range of the supra-threshold level. The results show that Litsea cubeba oil inhalation showed a sedative effect, observed from alpha and beta wave power reductions. The frontal and temporal regions of the brain were involved in the wave alterations. Garlic oil increased the alpha wave power at lower concentrations; however, a sedative effect was also observed at higher concentrations. Lower dilution oil induced changes in the fast alpha activity in the frontal region. The alpha and beta wave powers were decreased with higher dilution oils, particularly in the temporal, parietal, and occipital regions. Both Litsea cubeba and turmeric oils resulted in better positive moods than garlic oil. Garlic oil caused more negative moods than the others. The psychophysiological activities and the related brain functions require further investigation. The knowledge obtained from this study may be used to design functional food products.<\/jats:p>","DOI":"10.3390\/molecules26102939","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T23:17:16Z","timestamp":1621207036000},"page":"2939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of Thai Local Ingredient Odorants, Litsea cubeba and Garlic Essential Oils, on Brainwaves and Moods"],"prefix":"10.3390","volume":"26","author":[{"given":"Apsorn","family":"Sattayakhom","sequence":"first","affiliation":[{"name":"School of Allied Health Sciences, Walailak University, Nakhonsithammarat 80160, Thailand"},{"name":"Center of Excellence in Innovation on Essential Oil, Walailak University, Nakhonsithammarat 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumethee","family":"Songsamoe","sequence":"additional","affiliation":[{"name":"Center of Excellence in Innovation on Essential Oil, Walailak University, Nakhonsithammarat 80160, Thailand"},{"name":"School of Agricultural Technology, Walailak University, Nakhonsithammarat 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-4936","authenticated-orcid":false,"given":"Gorawit","family":"Yusakul","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Walailak University, Nakhonsithammarat 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosin","family":"Kalarat","sequence":"additional","affiliation":[{"name":"School of Informatics, Walailak University, Nakhonsithammarat 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumol","family":"Matan","sequence":"additional","affiliation":[{"name":"Center of Excellence in Innovation on Essential Oil, Walailak University, Nakhonsithammarat 80160, Thailand"},{"name":"School of Agricultural Technology, Walailak University, Nakhonsithammarat 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phanit","family":"Koomhin","sequence":"additional","affiliation":[{"name":"Center of Excellence in Innovation on Essential Oil, Walailak University, Nakhonsithammarat 80160, Thailand"},{"name":"School of Medicine, Walailak University, Nakhonsithammarat 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"ref_1","unstructured":"Research, G.V. (2021, March 30). Functional Foods Market Size, Share and Trends Analysis Report by Ingredient, by Product, by Application, and Segment Forecasts, 2019\u20132025. Available online: https:\/\/www.grandviewresearch.com\/industry-analysis\/functional-food-market."},{"key":"ref_2","first-page":"249","article-title":"The Evolution of Thai Curry Pastes","volume":"11","author":"Kanchanakunjara","year":"2018","journal-title":"DTC J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3989\/gya.033810","article-title":"Chemical composition, antioxidant and antimicrobial activity of the essential oil and methanol extract of the Egyptian lemongrass Cymbopogon proximus Stapf","volume":"62","author":"Selim","year":"2011","journal-title":"Grasas Aceites"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1089\/jmf.2010.0125","article-title":"Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass","volume":"14","author":"Caregnato","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jep.2011.07.003","article-title":"The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass)","volume":"137","author":"Costa","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_6","first-page":"17","article-title":"Antimicrobial effect of garlic essential oil on a number of food-borne pathogens and determination of its chemical composition and antioxidant potential","volume":"16","author":"Mehrnia","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1108\/00346650710749071","article-title":"Antioxidant, anti-inflammatory, and antimicrobial properties of garlic and onions","volume":"37","author":"Wilson","year":"2007","journal-title":"Nutr. Food Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8094","DOI":"10.1039\/C9FO00601J","article-title":"Garlic essential oil mediates acute and chronic mild stress-induced depression in rats via modulation of monoaminergic neurotransmission and brain-derived neurotrophic factor levels","volume":"10","author":"Huang","year":"2019","journal-title":"Food Funct."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4103\/0253-7613.84961","article-title":"An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L.","volume":"43","author":"Liju","year":"2011","journal-title":"Indian J. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.acthis.2014.03.002","article-title":"A blunted anxiolytic like effect of curcumin against acute lead induced anxiety in rat: Involvement of serotonin","volume":"116","author":"Benammi","year":"2014","journal-title":"Acta Histochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/jsfa.9305","article-title":"Blends of lemongrass derivatives and lime for the preparation of mixed beverages: Antioxidant, physicochemical, and sensory properties","volume":"99","author":"Kieling","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sowndhararajan, K., and Kim, S. (2016). Influence of Fragrances on Human Psychophysiological Activity: With Special Reference to Human Electroencephalographic Response. Sci. Pharm., 84.","DOI":"10.3390\/scipharm84040724"},{"key":"ref_13","first-page":"1047","article-title":"Aroma of Turmeric: Dependence on the Combination of Groups of Several Odor Constituents","volume":"10","author":"Hasegawa","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Koomhin, P., Sattayakhom, A., Chandharakool, S., Sinlapasorn, J., Suanjan, S., Palipoch, S., Na-Ek, P., Punsawad, C., and Matan, N. (2020). Michelia Essential Oil Inhalation Increases Fast Alpha Wave Activity. Sci. Pharm., 88.","DOI":"10.3390\/scipharm88020023"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chandharakool, S., Koomhin, P., Sinlapasorn, J., Suanjan, S., Phungsai, J., Suttipromma, N., Songsamoe, S., Matan, N., and Sattayakhom, A. (2020). Effects of Tangerine Essential Oil on Brain Waves, Moods, and Sleep Onset Latency. Molecules, 25.","DOI":"10.3390\/molecules25204865"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0031-9384(00)00308-5","article-title":"Ambient odor of orange in a dental office reduces anxiety and improves mood in female patients","volume":"71","author":"Lehrner","year":"2000","journal-title":"Physiol. Behav."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.physbeh.2005.06.031","article-title":"Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office","volume":"86","author":"Lehrner","year":"2005","journal-title":"Physiol. Behav."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0944-7113(98)80041-X","article-title":"The quantitative EEG as a screening instrument to identify sedative effects of single doses of plant extracts in comparison with diazepam","volume":"5","author":"Schulz","year":"1998","journal-title":"Phytomedicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrn2883","article-title":"Central mechanisms of odour object perception","volume":"11","author":"Gottfried","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/2045125312436573","article-title":"Plasma 1,8-cineole correlates with cognitive performance following exposure to rosemary essential oil aroma","volume":"2","author":"Moss","year":"2012","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0925-5273(98)00136-4","article-title":"A study of \u201cfragrance\u201d on working environment characteristics in VDT work activities","volume":"60-61","author":"Kawakami","year":"1999","journal-title":"Int. J. Prod. Econ."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1080\/07420520500263276","article-title":"An Olfactory Stimulus Modifies Nighttime Sleep in Young Men and Women","volume":"22","author":"Goel","year":"2005","journal-title":"Chronobiol. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3177\/jnsv.55.367","article-title":"Sub-Chronic Effects of (s)-Limonene on Brain Neurotransmitter Levels and Behavior of Rats","volume":"55","author":"Zhou","year":"2009","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Charret, T.S. (2021, March 30). Citral Effects on the Expression Profile of Brain-Derived Neurotrophic Factor and Inflammatory Cytokines in Status Epi-lepticus-Induced Rats Using the Lithium-Pilocarpine Model. Available online: https:\/\/www.liebertpub.com\/doi\/10.1089\/jmf.2020.0073.","DOI":"10.1089\/jmf.2020.0073"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.pharep.2016.03.014","article-title":"Natural terpenoids as a promising source for modulation of GABAergic system and treatment of neurological diseases","volume":"68","author":"Manayi","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/chemse\/18.1.1","article-title":"An analysis of spontaneous human cortical EEG activity to odours","volume":"18","author":"Toller","year":"1993","journal-title":"Chem. Senses"},{"key":"ref_27","first-page":"598","article-title":"The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity","volume":"95","author":"Sayorwan","year":"2012","journal-title":"J. Assoc. Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.5352\/JLS.2013.23.9.1170","article-title":"Effect of Essential Oil from San-Jo-In (Zizyphus jujuba Mill. seeds) on Human Electroencephalographic Activity","volume":"23","author":"Cho","year":"2013","journal-title":"J. Life Sci."},{"key":"ref_29","first-page":"23","article-title":"Neuroprotective effects of garlic a review","volume":"3","author":"Mathew","year":"2008","journal-title":"Libyan J. Med."},{"key":"ref_30","first-page":"1000397","article-title":"Antioxidant and Anti-Acetylcholinesterase Activities of Essential Oils from Garlic (Allium Sativum) Bulbs","volume":"31","author":"Akinyemi","year":"2018","journal-title":"Int. J. Plant. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jphs.2018.07.009","article-title":"Diallyl trisulfide regulates rat colonic smooth muscle contractions by inhibiting L-type calcium channel currents","volume":"137","author":"Tang","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.eujim.2017.11.005","article-title":"Effect of inhalation of isomers, (+)-\u03b1-pinene and (+)-\u03b2-pinene on human electroencephalographic activity according to gender difference","volume":"17","author":"Kim","year":"2018","journal-title":"Eur. J. Integr. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.eujim.2016.01.005","article-title":"Effect of inhalation of essential oil from Inula helenium L. root on electroencephalographic (EEG) activity of the human brain","volume":"8","author":"Sowndhararajan","year":"2016","journal-title":"Eur. J. Integr. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1037\/h0077714","article-title":"A circumplex model of affect","volume":"39","author":"Russell","year":"1980","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Plutchik, R., and Kellerman, H. (1989). Chapter 4\u2014MEASURES OF EMOTION. The Measurement of Emotions, Academic Press.","DOI":"10.1016\/B978-0-12-558704-4.50013-X"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/10\/2939\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:01:48Z","timestamp":1760162508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/10\/2939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["molecules26102939"],"URL":"https:\/\/doi.org\/10.3390\/molecules26102939","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,15]]}}}