{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:19:40Z","timestamp":1791638380412,"version":"4.3.4"},"reference-count":36,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discussed. Formation of the crystals is determined by the presence of the intermolecular O\u2013H\u2026N hydrogen bond that occur between fenamic acids and acridine. Intermolecular interactions stabilizing the crystals such as \u03c0\u2026\u03c0 stacking, C\u2013H\u2026X (X = O, Cl) intermolecular hydrogen bonds as well as C\u2013H\u2026\u03c0 and other dispersive interactions were analyzed by theoretical methods: the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction (NCI) approaches.<\/jats:p>","DOI":"10.3390\/molecules26102956","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T23:17:16Z","timestamp":1621207036000},"page":"2956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Crystal Structure and Intermolecular Interactions in Fenamic Acids\u2013Acridine Complexes"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0583-3709","authenticated-orcid":false,"given":"Marta S.","family":"Krawczyk","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Wroc\u0142aw Medical University, Borowska 211a, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Sroka","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Wroc\u0142aw Medical University, Borowska 211a, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Majerz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Wroc\u0142aw Medical University, Borowska 211a, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuint.2009.06.014","article-title":"Evidence for neuroprotection by the fenamate NSAID, mefenamic acid","volume":"55","author":"Khansari","year":"2009","journal-title":"Neurochem. 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