{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T10:33:58Z","timestamp":1775298838877,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"College Students Innovation and Entrepreneurship Training Program of Henan province","award":["S202011071009"],"award-info":[{"award-number":["S202011071009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A [3 + 2] 1,3-Dipolar cycloaddition of C,N-cyclic azomethine imines with allyl alkyl ketones has been achieved. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. An array of tetrahydroisoquinoline derivatives is generally constructed with good diastereoselectivities and enantioselectivities (up to &gt;25:1 dr, &gt;95% ee). Moreover, the absolute configuration of the product was previously determined by using the quantum electronic circular dichroism calculation and ECD spectrum method.<\/jats:p>","DOI":"10.3390\/molecules26102969","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T12:19:57Z","timestamp":1621253997000},"page":"2969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Asymmetric Synthesis of Tetrahydroisoquinoline Derivatives through 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with Allyl Alkyl Ketones"],"prefix":"10.3390","volume":"26","author":[{"given":"Guipeng","family":"Feng","sequence":"first","affiliation":[{"name":"School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, China"},{"name":"School of Pharmacy, Xinxiang University, Xinxiang 453000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyang","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Xinxiang University, Xinxiang 453000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Xinxiang University, Xinxiang 453000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Xinxiang University, Xinxiang 453000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6107-1019","authenticated-orcid":false,"given":"Kaikai","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Xinxiang University, Xinxiang 453000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2174\/1385272824999200420073539","article-title":"A Review on Metal-Free Oxidative \u03b1-Cyanation and Alkynylation of N-Substituted Tetrahydroisoquinolines as a Rapid Route for the Synthesis of Isoquinoline Alkaloids","volume":"24","author":"Kouznetsov","year":"2020","journal-title":"Curr. 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