{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:21:23Z","timestamp":1792099283701,"version":"4.4.0"},"reference-count":60,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Medicinal plants offer imperative sources of innovative chemical substances with important potential therapeutic effects. Among them, the members of the genus Inula have been widely used in traditional medicine for the treatment of several diseases. The present study investigated the antioxidant (DPPH, ABTS and FRAP assays) and the in vitro anti-hyperglycemic potential of aerial parts of Inula viscosa (L.) Aiton (I. viscosa) extracts through the inhibition of digestive enzymes (\u03b1-amylase and \u03b1-glucosidase), responsible of the digestion of poly and oligosaccharides. The polyphenolic profile of the Inula viscosa (L.) Aiton EtOAc extract was also investigated using HPLC-DAD\/ESI-MS analysis, whereas the volatile composition was elucidated by GC-MS. The chemical analysis resulted in the detection of twenty-one polyphenolic compounds, whereas the volatile profile highlighted the occurrence of forty-eight different compounds. Inula viscosa (L.) Aiton presented values as high as 87.2 \u00b1 0.50 mg GAE\/g and 78.6 \u00b1 0.55mg CE\/g, for gallic acid and catechin, respectively. The EtOAc extract exhibited the higher antioxidant activity compared to methanol and chloroform extracts in different tests with (IC50 = 0.6 \u00b1 0.03 \u00b5g\/mL; IC50 = 8.6 \u00b1 0.08 \u00b5g\/mL; 634.8 mg \u00b1 1.45 AAE\/g extract) in DPPH, ABTS and FRAP tests. Moreover, Inula viscosa (L.) Aiton leaves did show an important inhibitory effect against \u03b1-amylase and \u03b1-glucosidase. On the basis of the results achieved, such a species represents a promising traditional medicine, thanks to its remarkable content of functional bioactive compounds, thus opening new prospects for research and innovative phytopharmaceuticals developments.<\/jats:p>","DOI":"10.3390\/molecules26113134","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T23:35:05Z","timestamp":1621899305000},"page":"3134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Phytochemical Profile, Antioxidant Capacity, \u03b1-Amylase and \u03b1-Glucosidase Inhibitory Potential of Wild Moroccan Inula viscosa (L.) Aiton Leaves"],"prefix":"10.3390","volume":"26","author":[{"given":"Fadoua","family":"Asraoui","sequence":"first","affiliation":[{"name":"Laboratory of Applied Biology and Pathology, Department of Biology, Faculty of Sciences of Tetouan, Abdelmalek Essa\u00e2di University, Tetouan 93000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayoub","family":"Kounnoun","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biology and Pathology, Department of Biology, Faculty of Sciences of Tetouan, Abdelmalek Essa\u00e2di University, Tetouan 93000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1296-7633","authenticated-orcid":false,"given":"Francesco","family":"Cacciola","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8112-1474","authenticated-orcid":false,"given":"Fouad","family":"El Mansouri","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Engineering and Valorization of Resources, Department of Chemistry, Faculty of Sciences and Technology, Abdelmalek Essa\u00e2di University, Tangier 416, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-2898","authenticated-orcid":false,"given":"Imad","family":"Kabach","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Genetics, Faculty of Sciences and Technologies of Tangier, Tangier 416, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"Oulad El Majdoub","sequence":"additional","affiliation":[{"name":"Department of Chemical Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Alibrando","sequence":"additional","affiliation":[{"name":"Chromaleont s.r.l., c\/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Arena","sequence":"additional","affiliation":[{"name":"Department of Chemical Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3234-7650","authenticated-orcid":false,"given":"Emanuela","family":"Trovato","sequence":"additional","affiliation":[{"name":"Chromaleont s.r.l., c\/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-675X","authenticated-orcid":false,"given":"Luigi","family":"Mondello","sequence":"additional","affiliation":[{"name":"Department of Chemical Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"},{"name":"Chromaleont s.r.l., c\/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"},{"name":"Department of Sciences and Technologies for Human and Environment, University Campus Bio-Medico of Rome, 00128 Rome, Italy"},{"name":"BeSep s.r.l., c\/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnane","family":"Louajri","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biology and Pathology, Department of Biology, Faculty of Sciences of Tetouan, Abdelmalek Essa\u00e2di University, Tetouan 93000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yuan, H., Ma, Q., Ye, L., and Piao, G. 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