{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:37:20Z","timestamp":1783741040233,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["Profi 3"],"award-info":[{"award-number":["Profi 3"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie grant","award":["765378"],"award-info":[{"award-number":["765378"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Curcumin is known as a biologically active compound and a possible antimicrobial agent. Here, we combine it with TiO2 and ZnO semiconductors, known for their photocatalytic properties, with an eye towards synergistic photo-harvesting and\/or antimicrobial effects. We deposit different nanoscale multi-layer structures of curcumin, TiO2 and ZnO, by combining the solution-based spin-coating (S-C) technique and the gas-phase atomic layer deposition (ALD) and molecular layer deposition (MLD) thin-film techniques. As one of the highlights, we demonstrate for these multi-layer structures a red-shift in the absorbance maximum and an expansion of the absorbance edge as far as the longest visible wavelength region, which activates them for the visible light harvesting. The novel fabrication approaches introduced here should be compatible with, e.g., textile substrates, opening up new horizons for novel applications such as new types of protective masks with thin conformal antimicrobial coatings.<\/jats:p>","DOI":"10.3390\/molecules26113214","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T11:07:02Z","timestamp":1622113622000},"page":"3214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Photoactive Thin-Film Structures of Curcumin, TiO2 and ZnO"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-210X","authenticated-orcid":false,"given":"Anish","family":"Philip","sequence":"first","affiliation":[{"name":"Department of Chemistry and Materials Science, Aalto University, FI-00076 Espoo, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0861-220X","authenticated-orcid":false,"given":"Ramin","family":"Ghiyasi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Materials Science, Aalto University, FI-00076 Espoo, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-1169","authenticated-orcid":false,"given":"Maarit","family":"Karppinen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Materials Science, Aalto University, FI-00076 Espoo, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jff.2017.12.017","article-title":"Antiviral potential of curcumin","volume":"40","author":"Mathew","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ccr.2015.09.001","article-title":"Metal complexes of curcumin and curcumin derivatives for molecular imaging and anticancer therapy","volume":"307","author":"Schubert","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zorofchian Moghadamtousi, S., Abdul Kadir, H., Hassandarvish, P., Tajik, H., Abubakar, S., and Zandi, K. (2014). A review on antibacterial, antiviral, and antifungal activity of curcumin. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/186864"},{"key":"ref_4","first-page":"1935","article-title":"Evaluation of Antiviral Activities of Curcumin Derivatives","volume":"5","author":"Zandi","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0006-2952(95)98514-A","article-title":"Inhibition of human immunodeficiency virus type-1 integrase by curcumin","volume":"49","author":"Mazumder","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1039\/C5CS00088B","article-title":"Metal complexes of curcumin\u2014synthetic strategies, structures and medicinal applications","volume":"44","author":"Wanninger","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chen, T.Y., Chen, D.Y., Wen, H.W., Ou, J.L., Chiou, S.S., Chen, J.M., Wong, M.L., and Hsu, W.L. (2013). Inhibition of Enveloped Viruses Infectivity by Curcumin. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062482"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/ptr.6738","article-title":"Potential effects of curcumin in the treatment of COVID-19 infection","volume":"34","author":"Zahedipour","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1021\/jm070295s","article-title":"Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus","volume":"50","author":"Wen","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref_10","first-page":"1","article-title":"The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"13294","DOI":"10.1096\/fj.201901047RR","article-title":"Direct pulmonary delivery of solubilized curcumin reduces severity of lethal pneumonia","volume":"33","author":"Zhang","year":"2019","journal-title":"FASEB J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"109946","DOI":"10.1016\/j.biopha.2020.109946","article-title":"Curcumin regulates the differentiation of na\u00efve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice","volume":"125","author":"Chai","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1124\/pr.110.004044","article-title":"The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancers","volume":"66","author":"Heger","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: Problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1021\/acs.langmuir.7b00230","article-title":"Formation of Turmeric-Based Thin Films: Universal, Transparent Coatings","volume":"33","author":"Yeon","year":"2017","journal-title":"Langmuir"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"102214","DOI":"10.1016\/j.mtcomm.2021.102214","article-title":"Synthesis and photocatalytic performance of Bi2O3 thin films obtained in a homemade spin coater","volume":"27","author":"Falsetti","year":"2021","journal-title":"Mater. Today Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/app.50469","article-title":"Evaluation of mechanical properties and hydrophobicity of room-temperature, moisture-curable polysilazane coatings","volume":"138","author":"Zhan","year":"2021","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nnano.2014.181","article-title":"Growth of CH3NH3PbI3 cuboids with controlled size for high-efficiency perovskite solar cells","volume":"9","author":"Im","year":"2014","journal-title":"Nat. Nanotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kulikouskaya, V., Chyshankou, I., Pinchuk, S., Vasilevich, I., Volotovski, I., and Agabekov, V. (2020). Fabrication and characterization of ultrathin spin-coated poly(L-lactic acid) films suitable for cell attachment and curcumin loading. Biomed. Mater., 15.","DOI":"10.1088\/1748-605X\/aba40a"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/15421406.2011.654188","article-title":"AFM studies on curcumin based Zn(II) complex molecules for applications as anticancer agents","volume":"558","author":"Tone","year":"2012","journal-title":"Mol. Cryst. Liq. Cryst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1063\/1.105415","article-title":"Polymer films formed with monolayer growth steps by molecular layer deposition","volume":"59","author":"Yoshimura","year":"1991","journal-title":"Appl. Phys. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.3762\/bjnano.5.123","article-title":"Organic and inorganic-organic thin film structures by molecular layer deposition: A review","volume":"5","author":"Sundberg","year":"2014","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1002\/adma.200700079","article-title":"Synthesis and surface engineering of complex nanostructures by atomic layer deposition","volume":"19","author":"Knez","year":"2007","journal-title":"Adv. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.mattod.2014.04.026","article-title":"A brief review of atomic layer deposition: From fundamentals to applications","volume":"17","author":"Johnson","year":"2014","journal-title":"Mater. Today"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1021\/cr900056b","article-title":"Atomic layer deposition: An overview","volume":"110","author":"George","year":"2010","journal-title":"Chem. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1600459","DOI":"10.1002\/aelm.201600459","article-title":"Flexible Thermoelectric ZnO\u2013Organic Superlattices on Cotton Textile Substrates by ALD\/MLD","volume":"3","author":"Karttunen","year":"2017","journal-title":"Adv. Electron. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1021\/cm903831c","article-title":"Photo-controlled wettability switching by conformal coating of nanoscale topographies with ultrathin oxide films","volume":"22","author":"Malm","year":"2010","journal-title":"Chem. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2000535","DOI":"10.1002\/adem.202000535","article-title":"Textile-Integrated ZnO-Based Thermoelectric Device Using Atomic Layer Deposition","volume":"22","author":"Marin","year":"2020","journal-title":"Adv. Eng. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"010801","DOI":"10.1116\/1.4938104","article-title":"Atomic layer deposition on polymer fibers and fabrics for multifunctional and electronic textiles","volume":"34","author":"Brozena","year":"2016","journal-title":"J. Vac. Sci. Technol. A Vac. Surf. Film."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/cnma.202000638","article-title":"Visible-Light Absorbing TiO2:Curcumin Thin Films with ALD\/MLD","volume":"7","author":"Philip","year":"2021","journal-title":"ChemNanoMat"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"18326","DOI":"10.1039\/C7TA04449F","article-title":"An overview of molecular layer deposition for organic and organic-inorganic hybrid materials: Mechanisms, growth characteristics, and promising applications","volume":"5","author":"Meng","year":"2017","journal-title":"J. Mater. Chem. A"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1149\/1.2979975","article-title":"Deposition of Organic- Inorganic Hybrid Materials by Atomic Layer Deposition","volume":"16","author":"Nilsen","year":"2008","journal-title":"ECS Trans."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1701692","DOI":"10.1002\/admi.201701692","article-title":"Thermal Conductivity Reduction at Inorganic\u2013Organic Interfaces: From Regular Superlattices to Irregular Gradient Layer Sequences","volume":"5","author":"Krahl","year":"2018","journal-title":"Adv. Mater. Interfaces"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"21912","DOI":"10.1021\/acsami.0c04665","article-title":"Flexible \u03f5-Fe2O3-Terephthalate Thin-Film Magnets through ALD\/MLD","volume":"12","author":"Philip","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-019-0563-4","article-title":"Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: Another emerging application of nanomedicine","volume":"26","author":"Ghaffari","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jphotobiol.2006.09.002","article-title":"kui Photocatalysis effect of nanometer TiO2 and TiO2-coated ceramic plate on Hepatitis B virus","volume":"86","author":"Zan","year":"2007","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1134\/S1995078010050174","article-title":"Interaction of titanium dioxide nanoparticles with influenza virus","volume":"5","author":"Mazurkova","year":"2010","journal-title":"Nanotechnol. Russ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"043001","DOI":"10.1088\/0268-1242\/29\/4\/043001","article-title":"Atomic layer deposition of ZnO: A review","volume":"29","author":"Tynell","year":"2014","journal-title":"Semicond. Sci. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"093005","DOI":"10.1088\/1361-6641\/aa78ce","article-title":"Titanium dioxide thin films by atomic layer deposition: A review","volume":"32","author":"Marin","year":"2017","journal-title":"Semicond. Sci. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s40820-015-0040-x","article-title":"Review on zinc oxide nanoparticles: Antibacterial activity and toxicity mechanism","volume":"7","author":"Sirelkhatim","year":"2015","journal-title":"Nano-Micro Lett."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotochemrev.2015.08.003","article-title":"Visible-light activation of TiO2 photocatalysts: Advances in theory and experiments","volume":"25","author":"Etacheri","year":"2015","journal-title":"J. Photochem. Photobiol. C Photochem. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Buddee, S., Wongnawa, S., Sriprang, P., and Sriwong, C. (2014). Curcumin-sensitized TiO2 for enhanced photodegradation of dyes under visible light. J. Nanopart. Res., 16.","DOI":"10.1007\/s11051-014-2336-z"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s10971-015-3685-5","article-title":"Removal of dyes by photocatalytically active curcumin-sensitized amorphous TiO2 under visible light irradiation","volume":"75","author":"Buddee","year":"2015","journal-title":"J. Sol-Gel Sci. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"30785","DOI":"10.1039\/D0RA05755J","article-title":"Curcumin loaded zinc oxide nanoparticles for activity-enhanced antibacterial and anticancer applications","volume":"10","author":"Perera","year":"2020","journal-title":"RSC Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1039\/C4DT02550D","article-title":"Tunable optical properties of hybrid inorganic-organic [(TiO2)m(Ti-O-C6H4-O-)k]n superlattice thin films","volume":"44","author":"Karppinen","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.1016\/S1452-3981(23)12891-4","article-title":"Curcumin dye extracted from Curcuma longa L. used as sensitizers for efficient dye-sensitized solar cells","volume":"8","author":"Kim","year":"2013","journal-title":"Int. J. Electrochem. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s13659-018-0170-1","article-title":"Medicinal Plant Using Ground State Stabilization of Natural Antioxidant Curcumin by Keto-Enol Tautomerisation","volume":"8","author":"Manimaran","year":"2018","journal-title":"Nat. Prod. Bioprospect."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vibspec.2012.05.002","article-title":"Water soluble complexes of curcumin with cyclodextrins: Characterization by FT-Raman spectroscopy","volume":"62","author":"Mohan","year":"2012","journal-title":"Vib. Spectrosc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1021\/acs.chemmater.8b01833","article-title":"Reversible Photoswitching Function in Atomic\/Molecular-Layer-Deposited ZnO:Azobenzene Superlattice Thin Films","volume":"30","author":"Khayyami","year":"2018","journal-title":"Chem. Mater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/ejic.201301560","article-title":"Organic-inorganic thin films from TiCl4 and 4-aminophenol precursors: A model case of ALD\/MLD hybrid-material growth?","volume":"2014","author":"Sundberg","year":"2014","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/qua.20469","article-title":"DFT and experimental studies of the structure and vibrational spectra of curcumin","volume":"102","author":"Kolev","year":"2005","journal-title":"Int. J. Quantum Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"025012","DOI":"10.1088\/1361-6641\/abcee2","article-title":"Characterization of ZnO\/AlOx\/benzene thin-film heterostructures grown through atomic layer deposition\/molecular layer deposition","volume":"36","author":"Krahl","year":"2020","journal-title":"Semicond. Sci. Technol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"040602","DOI":"10.1116\/1.5105348","article-title":"Transition in layer structure of atomic\/molecular layer deposited ZnO-zincone multilayers","volume":"37","author":"Aghaee","year":"2019","journal-title":"J. Vac. Sci. Technol. A"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0022-0248(02)02133-4","article-title":"Surface morphology and crystallinity control in the atomic layer deposition (ALD) of hafnium and zirconium oxide thin films","volume":"249","author":"Hausmann","year":"2003","journal-title":"J. Cryst. Growth"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"15976","DOI":"10.1039\/D0RA02073G","article-title":"SCIP: A new simultaneous vapor phase coating and infiltration process for tougher and UV-resistant polymer fibers","volume":"10","author":"Azpitarte","year":"2020","journal-title":"RSC Adv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.scriptamat.2014.01.033","article-title":"Effect of particle size on the UV absorbance of zinc oxide nanoparticles","volume":"78\u201379","author":"Goh","year":"2014","journal-title":"Scr. Mater."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15504","DOI":"10.1039\/C9CP00907H","article-title":"Interplay between conformational and solvent effects in UV-visible absorption spectra: Curcumin tautomers as a case study","volume":"21","author":"Puglisi","year":"2019","journal-title":"Phys. Chem. Chem. Phys."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/11\/3214\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:08:59Z","timestamp":1760162939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/11\/3214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,27]]},"references-count":57,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["molecules26113214"],"URL":"https:\/\/doi.org\/10.3390\/molecules26113214","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,27]]}}}