{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:32:35Z","timestamp":1777044755415,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.<\/jats:p>","DOI":"10.3390\/molecules26113249","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T01:51:37Z","timestamp":1622425897000},"page":"3249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives"],"prefix":"10.3390","volume":"26","author":[{"given":"Han","family":"Luo","sequence":"first","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Feng","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9013-8489","authenticated-orcid":false,"given":"Jiang-Miao","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Mei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou-Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1248\/cpb.31.2353","article-title":"Studies on a Novel Anthraquinone and Its Glycosides isolated from Rubia cordifolia and R. akane","volume":"31","author":"Itokawa","year":"1983","journal-title":"Chem. 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