{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:34:40Z","timestamp":1782938080555,"version":"3.54.5"},"reference-count":72,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yong Deok Kim","award":["S2796569"],"award-info":[{"award-number":["S2796569"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The medicinal plant noni (Morinda citrifolia) is widely dispersed throughout Southeast Asia, the Caribbean, and Australia. We previously reported that fermented Noni could alleviate atopic dermatitis (AD) by recovering Th1\/Th2 immune balance and enhancing skin barrier function induced by 2,4-dinitrochlorobenzene. Noni has a high deacetylasperulosidic acid (DAA) content, whose concentration further increased in fermented noni as an iridoid constituent. This study aimed to determine the anti-AD effects and mechanisms of DAA on HaCaT, HMC-1, and EOL-1 cells. DAA inhibited the gene expression and secretion of AD-related cytokines and chemokines including interleukin (IL)-1\u03b2, IL-4, IL-6, IL-8, IL-25, IL-33, thymic stromal lymphopoietin, tumor necrosis factor-alpha, monocyte chemoattractant protein-1, thymus and activation-regulated chemokine, macrophage-derived chemokine, and regulated upon activation, normal T cell expressed and secreted, in all cells, and inhibited histamine release in HMC-1 cells. DAA controlled mitogen-activated protein kinase phosphorylation levels and the translocation of nuclear factor-kappa light chain enhancer of activated B cells into the nucleus by inhibiting I\u03baB\u03b1 decomposition in all the cells. Furthermore, DAA increased the expression of proteins involved in skin barrier functions such as filaggrin and involucrin in HaCaT cells. These results confirmed that DAA could relieve AD by controlling immune balance and recovering skin barrier function.<\/jats:p>","DOI":"10.3390\/molecules26113298","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T01:51:37Z","timestamp":1622425897000},"page":"3298","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Deacetylasperulosidic Acid on Atopic Dermatitis through Modulating Immune Balance and Skin Barrier Function in HaCaT, HMC-1, and EOL-1 Cells"],"prefix":"10.3390","volume":"26","author":[{"given":"Jin Su","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geum Su","family":"Seong","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju Gun 55365, Jeollabuk-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-6103","authenticated-orcid":false,"given":"Yong Deok","family":"Kim","sequence":"additional","affiliation":[{"name":"NST BIO Co., Ltd., Goeumdal-ro, Yangchon-eup, Gimpo-si 10049, Gyeonggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Young","family":"Choung","sequence":"additional","affiliation":[{"name":"Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea"},{"name":"Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/pai.13050","article-title":"rBlo t 5 is a potential contributor to the severity of atopic dermatitis in a Brazilian population","volume":"30","author":"Pierotti","year":"2019","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000068902","article-title":"It is true that, when Langerhans cells migrate from the skin to the lymph node, they are transported via lymph vessels","volume":"206","author":"Sugiura","year":"2003","journal-title":"Dermatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.1016\/j.jaad.2005.04.060","article-title":"The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis","volume":"53","author":"Novak","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kim, S.H., Seong, G.S., and Choung, S.Y. (2020). Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC\/Nga Mice through Modulating Immune Balance and Skin Barrier Function. Nutrients, 12.","DOI":"10.3390\/nu12010249"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/jcm4050858","article-title":"Immune Pathways in Atopic Dermatitis, and Definition of Biomarkers through Broad and Targeted Therapeutics","volume":"4","author":"Mansouri","year":"2015","journal-title":"J. Clin. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/jid.2009.71","article-title":"The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis","volume":"129","author":"Werfel","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaci.2018.11.014","article-title":"Insights into atopic dermatitis gained from genetically defined mouse models","volume":"143","author":"Nakajima","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1046\/j.0022-202x.2001.01493.x","article-title":"Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes","volume":"117","author":"Pummi","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kang, Y.M., Lee, K.Y., and An, H.J. (2018). Inhibitory Effects of Helianthus tuberosus Ethanol Extract on Dermatophagoides farina body-induced Atopic Dermatitis Mouse Model and Human Keratinocytes. Nutrients, 10.","DOI":"10.3390\/nu10111657"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.7150\/ijms.34323","article-title":"Poncirus Trifoliata (L.) Raf. Extract Inhibits the Development of Atopic Dermatitis-like Lesions in Human Keratinocytes and NC\/Nga mice","volume":"16","author":"Cha","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/exd.13865","article-title":"Therapeutic potential of topically administered gamma-AlOOH on 2,4-dinitrochlorobenzene-induced atopic dermatitis-like lesions in Balb\/c mice","volume":"28","author":"Bak","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00424-016-1903-9","article-title":"Tight junctions in skin inflammation","volume":"469","author":"Basler","year":"2017","journal-title":"Pflugers Arch."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.alit.2017.10.002","article-title":"Barrier dysfunction in the skin allergy","volume":"67","author":"Egawa","year":"2018","journal-title":"Allergol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0923-1811(03)00132-4","article-title":"Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): Changes in blood histamine and tryptase levels","volume":"33","author":"Imaizumi","year":"2003","journal-title":"J. Dermatol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Waljee, A.K., Rogers, M.A., Lin, P., Singal, A.G., Stein, J.D., Marks, R.M., Ayanian, J.Z., and Nallamothu, B.K. (2017). Short term use of oral corticosteroids and related harms among adults in the United States: Population based cohort study. BMJ, 357.","DOI":"10.1136\/bmj.j1415"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jgr.2016.02.003","article-title":"Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro","volume":"41","author":"Kee","year":"2017","journal-title":"J. Ginseng Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.0022-202X.2005.23840.x","article-title":"Mechanism of thymus- and activation-regulated chemokine (TARC)\/CCL17 production and its modulation by roxithromycin","volume":"125","author":"Komine","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/ACI.0000000000000133","article-title":"Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation","volume":"15","author":"Divekar","year":"2015","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.molimm.2009.03.018","article-title":"The adenylyl cyclase-cAMP system suppresses TARC\/CCL17 and MDC\/CCL22 production through p38 MAPK and NF-kappaB in HaCaT keratinocytes","volume":"46","author":"Qi","year":"2009","journal-title":"Mol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jep.2017.01.055","article-title":"Topical treatments of Saussurea costus root and Thuja orientalis L. synergistically alleviate atopic dermatitis-like skin lesions by inhibiting protease-activated receptor-2 and NF-kappaB signaling in HaCaT cells and Nc\/Nga mice","volume":"199","author":"Yang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbrc.2011.12.119","article-title":"Casuarinin suppresses TARC\/CCL17 and MDC\/CCL22 production via blockade of NF-\u03baB and STAT1 activation in HaCaT cells","volume":"417","author":"Kwon","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jdermsci.2006.06.002","article-title":"Thymus and activation regulated chemokine (TARC)\/CCL17 and skin diseases","volume":"43","author":"Saeki","year":"2006","journal-title":"J. Dermatol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1074\/jbc.273.3.1764","article-title":"Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4","volume":"273","author":"Imai","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1067\/mai.2001.113237","article-title":"Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity","volume":"107","author":"Kakinuma","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jdermsci.2006.08.004","article-title":"Macrophage-derived chemokine (MDC)\/CCL22 produced by monocyte derived dendritic cells reflects the disease activity in patients with atopic dermatitis","volume":"44","author":"Hashimoto","year":"2006","journal-title":"J. Dermatol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jdermsci.2004.01.001","article-title":"Both Th2 and Th1 chemokines (TARC\/CCL17, MDC\/CCL22, and Mig\/CXCL9) are elevated in sera from patients with atopic dermatitis","volume":"34","author":"Shimada","year":"2004","journal-title":"J. Dermatol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1067\/mai.2001.114707","article-title":"Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines","volume":"107","author":"Giustizieri","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4168\/aair.2012.4.1.12","article-title":"Epidermal barrier in atopic dermatitis","volume":"4","author":"Kim","year":"2012","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jaip.2014.03.006","article-title":"Skin barrier and immune dysregulation in atopic dermatitis: An evolving story with important clinical implications","volume":"2","author":"Czarnowicki","year":"2014","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbadis.2010.12.014","article-title":"Mast cells and inflammation","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/jid.2011.435","article-title":"Skin barrier disruption: A requirement for allergen sensitization?","volume":"132","author":"Kubo","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.coi.2009.09.006","article-title":"Mast cells in atopic dermatitis","volume":"21","author":"Kawakami","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12016-011-8252-4","article-title":"IgE, mast cells, and eosinophils in atopic dermatitis","volume":"41","author":"Liu","year":"2011","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2183\/pjab.87.463","article-title":"Interleukin-5 and IL-5 receptor in health and diseases","volume":"87","author":"Takatsu","year":"2011","journal-title":"Proc. Jpn Acad. Ser. B Phys. Biol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.lfs.2012.07.021","article-title":"Effect of (E)-2-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-7-yl-3-(3,4-dimethoxyphenyl) acrylate on the development of atopic dermatitis-like lesions","volume":"91","author":"Kim","year":"2012","journal-title":"Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Moustaka, K., Maleskou, E., Lambrianidou, A., Papadopoulos, S., Lekka, M.E., Trangas, T., and Kitsiouli, E. (2019). Docosahexaenoic Acid Inhibits Proliferation of EoL-1 Leukemia Cells and Induces Cell Cycle Arrest and Cell Differentiation. Nutrients, 11.","DOI":"10.3390\/nu11030574"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3892\/mmr.2013.1520","article-title":"Arazyme inhibits cytokine expression and upregulates skin barrier protein expression","volume":"8","author":"Kim","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.fitote.2010.08.015","article-title":"The classical drug discovery approach to defining bioactive constituents of botanicals","volume":"82","author":"Kinghorn","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jep.2010.08.063","article-title":"Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican noni juice (Morinda citrifolia L.)","volume":"133","author":"Dussossoy","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7489","DOI":"10.1021\/jf071359a","article-title":"Identification of TLC markers and quantification by HPLC-MS of various constituents in noni fruit powder and commercial noni-derived products","volume":"55","author":"Potterat","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Pandy, V., Bonam, S.R., Raya, A.R., and Nadendla, R.R. (2020). Morinda citrifolia Linn.(Noni) fruit, antioxidant effects, and neuroprotection. Oxidative Stress and Dietary Antioxidants in Neurological Diseases, Elsevier.","DOI":"10.1016\/B978-0-12-817780-8.00019-0"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/ptr.6061","article-title":"Pinus densiflora bark extract ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC\/Nga mice by regulating Th1\/Th2 balance and skin barrier function","volume":"32","author":"Lee","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11895","DOI":"10.1038\/s41598-018-30404-x","article-title":"Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC\/Nga mice","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/fsn3.21","article-title":"Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers","volume":"1","author":"Wang","year":"2013","journal-title":"Food Sci. Nutr"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"He, J., Lu, X., Wei, T., Dong, Y., Cai, Z., Tang, L., and Liu, M. (2018). Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-kappaB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19072027"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jgr.2018.02.008","article-title":"Ginsenoside Rg3 suppresses mast cell-mediated allergic inflammation via mitogen-activated protein kinase signaling pathway","volume":"43","author":"Kee","year":"2019","journal-title":"J. Ginseng Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00011-009-0074-y","article-title":"The RBL-2H3 cell line: Its provenance and suitability as a model for the mast cell","volume":"58","author":"Passante","year":"2009","journal-title":"Inflamm. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1182\/blood.V66.6.1233.1233","article-title":"Establishment and characterization of a new human eosinophilic leukemia cell line","volume":"66","author":"Saito","year":"1985","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.21.120601.141025","article-title":"Mast cells as \u201ctunable\u201d effector and immunoregulatory cells: Recent advances","volume":"23","author":"Galli","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Choi, E.J., Iwasa, M., Han, K.I., Kim, W.J., Tang, Y., Hwang, Y.J., Chae, J.R., Han, W.C., Shin, Y.S., and Kim, E.K. (2016). Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model. Nutrients, 8.","DOI":"10.3390\/nu8030146"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.intimp.2015.04.047","article-title":"Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis","volume":"28","author":"Zhu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev.immunol.21.120601.141103","article-title":"The biology of IGE and the basis of allergic disease","volume":"21","author":"Gould","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3892\/ijmm.2013.1430","article-title":"Vigna angularis inhibits mast cell-mediated allergic inflammation","volume":"32","author":"Kim","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8085615","DOI":"10.1155\/2020\/8085615","article-title":"Elevated Levels of Activated and Pathogenic Eosinophils Characterize Moderate-Severe House Dust Mite Allergic Rhinitis","volume":"2020","author":"Chen","year":"2020","journal-title":"J. Immunol. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/35006097","article-title":"Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1","volume":"404","author":"Gu","year":"2000","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1081\/JAS-200063001","article-title":"Eosinophils from asthmatics release IL-5 in an autocrine fashion to prevent apoptosis through upregulation of Bcl-2 expression","volume":"42","author":"Huang","year":"2005","journal-title":"J. Asthma"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s40521-019-00219-w","article-title":"Atopic Dermatitis and Type 2 Immune Deviation","volume":"6","author":"Furue","year":"2019","journal-title":"Curr. Treat. Opt. Allergy"},{"key":"ref_58","first-page":"e27350","article-title":"Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells","volume":"8","author":"Li","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.jaci.2020.10.006","article-title":"Dual function of Langerhans cells in skin TSLP-promoted TFH differentiation in mouse atopic dermatitis","volume":"147","author":"Marschall","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1590\/abd1806-4841.20164412","article-title":"Skin barrier in atopic dermatitis: Beyond filaggrin","volume":"91","author":"Zaniboni","year":"2016","journal-title":"An. Bras. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2016.05.002","article-title":"Atopic dermatitis and filaggrin","volume":"42","author":"Cabanillas","year":"2016","journal-title":"Curr. Opin. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.clim.2007.11.006","article-title":"Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6","volume":"126","author":"Kim","year":"2008","journal-title":"Clin. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.it.2013.12.001","article-title":"A new itch to scratch for TSLP","volume":"35","author":"Turner","year":"2014","journal-title":"Trends Immunol."},{"key":"ref_64","first-page":"899","article-title":"Role of the epidermal barrier in atopic dermatitis","volume":"7","author":"Proksch","year":"2009","journal-title":"J. Dtsch Dermatol. Ges."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrd3838","article-title":"Targeting eosinophils in allergy, inflammation and beyond","volume":"12","author":"Fulkerson","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: Changing perspectives in health and disease","volume":"13","author":"Rosenberg","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1067\/mai.2001.120015","article-title":"A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months\u2019 treatment and 18 months\u2019 posttreatment follow-up","volume":"108","author":"Warner","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2010.02.026","article-title":"What targeting eosinophils has taught us about their role in diseases","volume":"126","author":"Bochner","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.cyto.2011.03.007","article-title":"Thymic stromal lymphopoietin is expressed and produced by caspase-1\/NF-kappaB pathway in mast cells","volume":"54","author":"Moon","year":"2011","journal-title":"Cytokine"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1365-2567.2008.02916.x","article-title":"Signalling mechanisms regulating the activation of human eosinophils by mast-cell-derived chymase: Implications for mast cell-eosinophil interaction in allergic inflammation","volume":"126","author":"Wong","year":"2009","journal-title":"Immunology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"113773","DOI":"10.1016\/j.jep.2020.113773","article-title":"Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3\/MAPK\/NF-kappaB signaling pathways","volume":"270","author":"Xiong","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8863","DOI":"10.3892\/mmr.2017.7689","article-title":"P38\/ERK MAPK signaling pathways are involved in the regulation of filaggrin and involucrin by IL17","volume":"16","author":"Tan","year":"2017","journal-title":"Mol. Med. 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