{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:42:47Z","timestamp":1787902967405,"version":"build-2784847793"},"reference-count":257,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dendrimers comprise a specific group of macromolecules, which combine structural properties of both single molecules and long expanded polymers. The three-dimensional form of dendrimers and the extensive possibilities for use of additional substrates for their construction creates a multivalent potential and a wide possibility for medical, diagnostic and environmental purposes. Depending on their composition and structure, dendrimers have been of interest in many fields of science, ranging from chemistry, biotechnology to biochemical applications. These compounds have found wide application from the production of catalysts for their use as antibacterial, antifungal and antiviral agents. Of particular interest are peptide dendrimers as a medium for transport of therapeutic substances: synthetic vaccines against parasites, bacteria and viruses, contrast agents used in MRI, antibodies and genetic material. This review focuses on the description of the current classes of dendrimers, the methodology for their synthesis and briefly drawbacks of their properties and their use as potential therapies against infectious diseases.<\/jats:p>","DOI":"10.3390\/molecules26113304","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T05:53:38Z","timestamp":1622440418000},"page":"3304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9285-8298","authenticated-orcid":false,"given":"Nina","family":"Filipczak","sequence":"first","affiliation":[{"name":"Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2941-0754","authenticated-orcid":false,"given":"Satya Siva Kishan","family":"Yalamarty","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA"},{"name":"State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Chinese Medicine, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-3841","authenticated-orcid":false,"given":"Farzana","family":"Parveen","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA"},{"name":"The Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Torchilin","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA"},{"name":"Department of Oncology, Radiotherapy and Plastic Surgery, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"ref_1","first-page":"742","article-title":"Progress in Nanomedicine: Approved and Investigational Nanodrugs","volume":"42","author":"Ventola","year":"2017","journal-title":"Pharm. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.biopha.2017.11.026","article-title":"Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world","volume":"97","author":"Prasad","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sharma, S. (2021). Dendrimers in Nanomedicine: History, Concept and Properties of Dendrimers. Dendrimers in Nanomedicine, CRC Press.","DOI":"10.1201\/9781003029915-3"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Song, C., Shen, M., Rodrigues, J., Mignani, S., Majoral, J.-P., and Shi, X. (2020). Superstructured poly (amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: A concise review. Coord. Chem. Rev., 421.","DOI":"10.1016\/j.ccr.2020.213463"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12272-018-1008-4","article-title":"Recent progress in dendrimer-based nanomedicine development","volume":"41","author":"Kim","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Le, N.T.T., Nguyen, T.N.Q., Cao, V.D., Hoang, D.T., Ngo, V.C., and Hoang Thi, T.T. (2019). Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11110591"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1039\/C7SC00097A","article-title":"Synthetically controlling dendrimer flexibility improves delivery of large plasmid DNA","volume":"8","author":"Kretzmann","year":"2017","journal-title":"Chem. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.2174\/138161209789058200","article-title":"Dendrimers: A class of polymers in the nanotechnology for the delivery of active pharmaceuticals","volume":"15","author":"Samad","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijpharm.2018.05.045","article-title":"Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA\/siRNA for cancer therapy","volume":"546","author":"Li","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ara\u00fajo, R.V., Santos, S.D.S., Igne Ferreira, E., and Giarolla, J. (2018). New Advances in General Biomedical Applications of PAMAM Dendrimers. Molecules, 23.","DOI":"10.3390\/molecules23112849"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.saa.2011.07.009","article-title":"Interaction of polyamidoamine (PAMAM) succinamic acid dendrimers generation 4 with human serum albumin","volume":"81","author":"Sekowski","year":"2011","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Idris, A.O., Mamba, B., and Feleni, U. (2020). Poly (propylene imine) dendrimer: A potential nanomaterial for electrochemical application. Mater. Chem. Phys., 244.","DOI":"10.1016\/j.matchemphys.2020.122641"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1080\/09205063.2015.1133155","article-title":"Dendrimer-mediated approaches for the treatment of brain tumor","volume":"27","author":"Dwivedi","year":"2016","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11051-016-3423-0","article-title":"A review on comparative study of PPI and PAMAM dendrimers","volume":"18","author":"Kaur","year":"2016","journal-title":"J. Nanoparticle Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ejpb.2013.10.018","article-title":"Development and characterization of sulfasalazine loaded fucosylated PPI dendrimer for the treatment of cytokine-induced liver damage","volume":"86","author":"Gupta","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1039\/C7TB02585H","article-title":"Construction of core-shell tecto dendrimers based on supramolecular host-guest assembly for enhanced gene delivery","volume":"5","author":"Chen","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"22343","DOI":"10.1039\/C9NR08309J","article-title":"Core-shell tecto dendrimers formed via host-guest supramolecular assembly as pH-responsive intelligent carriers for enhanced anticancer drug delivery","volume":"11","author":"Wang","year":"2019","journal-title":"Nanoscale"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Song, C., Gao, Y., Chen, J., Wang, L., B\u00e1nyai, I., Shen, M., and Shi, X. (2021). Physicochemical aspects of zwitterionic core-shell tecto dendrimers characterized by a thorough NMR investigation. Colloids Surf. A Physicochem. Eng. Asp., 618.","DOI":"10.1016\/j.colsurfa.2021.126466"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.tetasy.2017.10.028","article-title":"Synthesis of chiral carbosilane dendrimers with l-cysteine and N-acetyl-l-cysteine on their surface and their application as chiral selectors for enantiomer separation by capillary electrophoresis","volume":"28","author":"Quintana","year":"2017","journal-title":"Tetrahedron Asymmetry"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Seebach, D., Rheiner, P.B., Greiveldinger, G., Butz, T., and Sellner, H. (1998). Chiral dendrimers. Dendrimers, 125\u2013164.","DOI":"10.1007\/3-540-69779-9_4"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ijpharm.2018.07.030","article-title":"Dendrimers: A versatile nanocarrier for drug delivery and targeting","volume":"548","author":"Sherje","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Zhu, X., Jiang, W., Liu, H., and Sun, B. (2021). Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects. Molecules, 26.","DOI":"10.3390\/molecules26041145"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"41778","DOI":"10.1039\/C4RA04967E","article-title":"Synthesis of chiral core based triazole dendrimers with m-terphenyl surface unit and their antibacterial studies","volume":"4","author":"Thirunarayanan","year":"2014","journal-title":"RSC Adv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1073\/pnas.082013899","article-title":"Dendrimers and supramolecular chemistry","volume":"99","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/adma.19960080509","article-title":"A mesogen-functionized carbosilane dendrimer: A dendritic liquid crystalline polymer","volume":"8","author":"Lorenz","year":"1996","journal-title":"Adv. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/masy.19961020105","article-title":"Dendritic polyols based on carbosilanes-lipophilic dendrimers with hydrophilic skin","volume":"102","author":"Frey","year":"1996","journal-title":"Macromol. Symp."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Aya, S., Haba, O., Yonetake, K., and Araoka, F. (2021). Anchoring and molecular conformation of liquid crystalline dendrimer. J. Mol. Liq., 321.","DOI":"10.1016\/j.molliq.2020.114379"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tabatabaei Mirakabad, F.S., Khoramgah, M.S., Keshavarz, F.K., Tabarzad, M., and Ranjbari, J. (2019). Peptide dendrimers as valuable biomaterials in medical sciences. Life Sci., 233.","DOI":"10.1016\/j.lfs.2019.116754"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1021\/jacs.7b11037","article-title":"Lipidated Peptide Dendrimers Killing Multidrug-Resistant Bacteria","volume":"140","author":"Siriwardena","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijpharm.2017.02.002","article-title":"Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen","volume":"521","author":"Manikkath","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chauhan, A.S. (2018). Dendrimers for Drug Delivery. Molecules, 23.","DOI":"10.3390\/molecules23040938"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/s11095-014-1506-0","article-title":"Dendrimer-stabilized smart-nanoparticle (DSSN) platform for targeted delivery of hydrophobic antitumor therapeutics","volume":"32","author":"Tekade","year":"2015","journal-title":"Pharm. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1021\/acs.accounts.0c00589","article-title":"Self-assembling supramolecular dendrimers for biomedical applications: Lessons learned from poly (amidoamine) dendrimers","volume":"53","author":"Lyu","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1039\/C9TB02289A","article-title":"Dendrimer nanoparticles for colorectal cancer applications","volume":"8","author":"Carvalho","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1295\/polymj.17.117","article-title":"A new class of polymers: Starburst-dendritic macromolecules","volume":"17","author":"Tomalia","year":"1985","journal-title":"Polym. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1039\/c2cs35062a","article-title":"Simplifying the synthesis of dendrimers: Accelerated approaches","volume":"41","author":"Walter","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mtchem.2019.04.004","article-title":"Poly (amidoamine) dendrimers: Covalent and supramolecular synthesis","volume":"13","author":"Lyu","year":"2019","journal-title":"Mater. Today Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7638","DOI":"10.1021\/ja00177a027","article-title":"Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules","volume":"112","author":"Hawker","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hawker, C., and Fr\u00e9chet, J.M. (1990). A new convergent approach to monodisperse dendritic macromolecules. J. Chem. Soc. Chem. Commun., 1010\u20131013.","DOI":"10.1039\/C39900001010"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Palmerston Mendes, L., Pan, J., and Torchilin, V.P. (2017). Dendrimers as nanocarriers for nucleic acid and drug delivery in cancer therapy. Molecules, 22.","DOI":"10.3390\/molecules22091401"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bondareva, J., Kolotylo, M., Rozhkov, V., Burilov, V., and Lukin, O. (2020). A convergent approach to sulfonimide-based dendrimers and dendrons. Tetrahedron Lett., 61.","DOI":"10.1016\/j.tetlet.2020.152011"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1021\/ja00011a031","article-title":"Hyperbranched macromolecules via a novel double-stage convergent growth approach","volume":"113","author":"Wooley","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1002\/ange.200454078","article-title":"Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper (I)-catalyzed ligation of azides and alkynes","volume":"116","author":"Wu","year":"2004","journal-title":"Angew. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.7324\/JAPS.2015.50321","article-title":"Dendrimers: A Review on Synthetic Approaches","volume":"5","author":"Gupta","year":"2015","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.addr.2013.01.001","article-title":"Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: A concise overview","volume":"65","author":"Mignani","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0014-3057(03)00100-9","article-title":"Dendrimers: A new class of nanoscopic containers and delivery devices","volume":"39","author":"Aulenta","year":"2003","journal-title":"Eur. Polym. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.addr.2005.09.017","article-title":"Dendrimers in gene delivery","volume":"57","author":"Uchegbu","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1021\/jm0401863","article-title":"Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy","volume":"48","author":"Majoros","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1021\/jm040187v","article-title":"Targeting and inhibition of cell growth by an engineered dendritic nanodevice","volume":"48","author":"Thomas","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1016\/j.biomaterials.2010.12.060","article-title":"Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy","volume":"32","author":"Wang","year":"2011","journal-title":"Biomaterials"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.biomaterials.2011.10.052","article-title":"PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography","volume":"33","author":"Peng","year":"2012","journal-title":"Biomaterials"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/wnan.1198","article-title":"Gadolinium-based contrast agents for magnetic resonance cancer imaging","volume":"5","author":"Zhou","year":"2013","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0378-5173(99)00463-9","article-title":"Polyamidoamine Starburst dendrimers as solubility enhancers","volume":"197","author":"Milhem","year":"2000","journal-title":"Int. J. Pharm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijpharm.2005.07.023","article-title":"Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins","volume":"304","author":"Devarakonda","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1039\/C6RA26511A","article-title":"PAMAM\/5-fluorouracil drug conjugate for targeting E6 and E7 oncoproteins in cervical cancer: A combined experimental\/in silico approach","volume":"7","author":"Rengaraj","year":"2017","journal-title":"RSC Adv."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.ejmech.2006.01.001","article-title":"Dendrimers as potential drug carriers. Part II. Prolonged delivery of ketoprofen by in vitro and in vivo studies","volume":"41","author":"Na","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jbm.a.36830","article-title":"A comparative study on solubility improvement of tetracycline and dexamethasone by poly (propylene imine) and polyamidoamine dendrimers: An insight into cytotoxicity and cell proliferation","volume":"108","author":"Najafi","year":"2020","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kulhari, H., Pooja, D., Shrivastava, S., Kuncha, M., Naidu, V.G.M., Bansal, V., Sistla, R., and Adams, D.J. (2016). Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer. Sci. Rep., 6.","DOI":"10.1038\/srep23179"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0168-1656(01)00276-0","article-title":"An efficient gene transfer system for hematopoietic cell line using transient and stable vectors","volume":"88","author":"Teixeira","year":"2001","journal-title":"J. Biotechnol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejpb.2019.01.006","article-title":"Polyamidoamine dendrimers-based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance","volume":"136","author":"Pan","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1128\/IAI.00533-10","article-title":"Multiple antigen peptide vaccines against Plasmodium falciparum malaria","volume":"78","author":"Mahajan","year":"2010","journal-title":"Infect. Immun."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Karpenko, L.I., Apartsin, E.K., Dudko, S.G., Starostina, E.V., Kaplina, O.N., Antonets, D.V., Volosnikova, E.A., Zaitsev, B.N., Bakulina, A.Y., and Venyaminova, A.G. (2020). Cationic Polymers for the Delivery of the Ebola DNA Vaccine Encoding Artificial T-Cell Immunogen. Vaccines, 8.","DOI":"10.3390\/vaccines8040718"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1016\/j.bmc.2009.06.036","article-title":"Systematic syntheses of influenza neuraminidase inhibitors: A series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties","volume":"17","author":"Sakamoto","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Price, C.F., Tyssen, D., Sonza, S., Davie, A., Evans, S., Lewis, G.R., Xia, S., Spelman, T., Hodsman, P., and Moench, T.R. (2011). SPL7013 Gel (VivaGel\u00ae) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024095"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2174\/1570159X16666180918164623","article-title":"Alzheimer\u2019s Disease\u2014Future Therapy Based on Dendrimers","volume":"17","author":"Aliev","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Geiger, B.C., Wang, S., Padera, R.F., Grodzinsky, A.J., and Hammond, P.T. (2018). Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis. Sci. Transl. Med., 10.","DOI":"10.1126\/scitranslmed.aat8800"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Fruchon, S., and Poupot, R. (2018). The ABP Dendrimer, a Drug-Candidate against Inflammatory Diseases That Triggers the Activation of Interleukin-10 Producing Immune Cells. Molecules, 23.","DOI":"10.3390\/molecules23061272"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.drudis.2008.03.010","article-title":"Whither antibacterial drug discovery?","volume":"13","author":"Projan","year":"2008","journal-title":"Drug Discov. Today"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1039\/C1NJ20481E","article-title":"Dendrimers as bactericides","volume":"36","author":"Castonguay","year":"2012","journal-title":"New J. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1016\/S0142-9612(02)00036-4","article-title":"Interactions between dendrimer biocides and bacterial membranes","volume":"23","author":"Chen","year":"2002","journal-title":"Biomaterials"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1039\/B901839P","article-title":"Biomedical applications of dendrimers: A tutorial","volume":"40","author":"Mintzer","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1021\/nl005502p","article-title":"Dendrimer\u2212 silver complexes and nanocomposites as antimicrobial agents","volume":"1","author":"Balogh","year":"2001","journal-title":"Nano Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/mp2005033","article-title":"Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases","volume":"9","author":"Mintzer","year":"2012","journal-title":"Mol. Pharm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/wnan.1181","article-title":"Dendrimers\u2014Revolutionary drugs for infectious diseases","volume":"4","author":"Lazniewska","year":"2012","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1086\/520139","article-title":"Longer-term immunologic effects and side effects of successful antiretroviral therapy","volume":"29","author":"Schooley","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1073\/pnas.1318249111","article-title":"Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues","volume":"111","author":"Fletcher","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1021\/mp050023q","article-title":"Dendrimers as drugs: Discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention","volume":"2","author":"McCarthy","year":"2005","journal-title":"Mol. Pharm."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ejpb.2009.03.006","article-title":"Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment","volume":"72","author":"Baert","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.nano.2015.03.009","article-title":"Nanoformulation of antiretroviral drugs enhances their penetration across the blood brain barrier in mice","volume":"11","author":"Fiandra","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/00002030-198800001-00003","article-title":"The role of the CD4 antigen in HIV infection and immune pathogenesis","volume":"2","author":"Sattentau","year":"1988","journal-title":"Aids"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(88)90397-2","article-title":"The CD4 antigen: Physiological ligand and HIV receptor","volume":"52","author":"Sattentau","year":"1988","journal-title":"Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1021\/acs.bioconjchem.8b00106","article-title":"Anionic Carbosilane Dendrimers Destabilize the GP120-CD4 Complex Blocking HIV-1 Entry and Cell to Cell Fusion","volume":"29","author":"Serramia","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.nano.2015.04.013","article-title":"Prevention vaginally of HIV-1 transmission in humanized BLT mice and mode of antiviral action of polyanionic carbosilane dendrimer G2-S16","volume":"11","author":"Tager","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"899","DOI":"10.2217\/nnm.14.79","article-title":"Triple combination of carbosilane dendrimers, tenofovir and maraviroc as potential microbicide to prevent HIV-1 sexual transmission","volume":"10","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejphar.2017.05.060","article-title":"Efficacy of carbosilane dendrimers with an antiretroviral combination against HIV-1 in the presence of semen-derived enhancer of viral infection","volume":"811","author":"Resino","year":"2017","journal-title":"Eur. J. Pharm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2014.03.048","article-title":"Carbosilane dendrimers as gene delivery agents for the treatment of HIV infection","volume":"184","author":"Gomez","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1021\/jp100271w","article-title":"Ability to adapt: Different generations of PAMAM dendrimers show different behaviors in binding siRNA","volume":"114","author":"Pavan","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1038\/mt.2011.207","article-title":"Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice","volume":"19","author":"Zhou","year":"2011","journal-title":"Mol. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cub.2008.07.079","article-title":"Transportin-SR2 imports HIV into the nucleus","volume":"18","author":"Christ","year":"2008","journal-title":"Curr. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/sj.mt.6300157","article-title":"Safety and efficacy of a lentiviral vector containing three anti-HIV genes\u2014CCR5 ribozyme, tat-rev siRNA, and TAR decoy\u2014In SCID-hu mouse\u2013derived T cells","volume":"15","author":"Anderson","year":"2007","journal-title":"Mol. Ther."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Gurunathan, S., Qasim, M., Choi, Y., Do, J.T., Park, C., Hong, K., Kim, J.H., and Song, H. (2020). Antiviral Potential of Nanoparticles-Can Nanoparticles Fight against Coronaviruses?. Nanomaterials, 10.","DOI":"10.3390\/nano10091645"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Witika, B.A., Makoni, P.A., Mweetwa, L.L., Ntemi, P.V., Chikukwa, M.T.R., Matafwali, S.K., Mwila, C., Mudenda, S., Katandula, J., and Walker, R.B. (2020). Nano-Biomimetic Drug Delivery Vehicles: Potential Approaches for COVID-19 Treatment. Molecules, 25.","DOI":"10.3390\/molecules25245952"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.addr.2020.12.008","article-title":"Non-viral COVID-19 vaccine delivery systems","volume":"169","author":"Park","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Li, Y.D., Chi, W.Y., Su, J.H., Ferrall, L., Hung, C.F., and Wu, T.C. (2020). Coronavirus vaccine development: From SARS and MERS to COVID-19. J. Biomed. Sci., 27.","DOI":"10.1186\/s12929-020-00695-2"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMoa2022483","article-title":"An mRNA Vaccine against SARS-CoV-2\u2014Preliminary Report","volume":"383","author":"Jackson","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.15585\/mmwr.mm6950e2","article-title":"The Advisory Committee on Immunization Practices\u2019 Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine\u2014United States, December 2020","volume":"69","author":"Oliver","year":"2020","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s41551-018-0284-0","article-title":"Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA","volume":"2","author":"Islam","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Cheng, Q., Wei, T., Jia, Y., Farbiak, L., Zhou, K., Zhang, S., Wei, Y., Zhu, H., and Siegwart, D.J. (2018). Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I. Adv. Mater., 30.","DOI":"10.1002\/adma.201805308"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jconrel.2020.06.030","article-title":"Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo","volume":"325","author":"Xiong","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.ymthe.2019.02.012","article-title":"Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery","volume":"27","author":"Kowalski","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2174\/1389450120666191031092259","article-title":"Understanding the Pharmaceutical Aspects of Dendrimers for the Delivery of Anticancer Drugs","volume":"21","author":"Dubey","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/jmv.25928","article-title":"A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus","volume":"92","author":"Kandeel","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Khaitov, M., Nikonova, A., Shilovskiy, I., Kozhikhova, K., Kofiadi, I., Vishnyakova, L., Nikolskii, A., Gattinger, P., Kovchina, V., and Barvinskaia, E. (2021). Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation. Allergy.","DOI":"10.22541\/au.161359798.81563481\/v1"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1213\/ANE.0000000000000866","article-title":"Ebola Virus Disease: A Review of Its Past and Present","volume":"121","author":"Murray","year":"2015","journal-title":"Anesth. Analg."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1128\/JVI.76.13.6841-6844.2002","article-title":"C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans","volume":"76","author":"Alvarez","year":"2002","journal-title":"J. Virol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/viro.2002.1730","article-title":"DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells","volume":"305","author":"Simmons","year":"2003","journal-title":"Virology"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/jac\/dkh399","article-title":"Glycodendritic structures: Promising new antiviral drugs","volume":"54","author":"Rojo","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1128\/AAC.47.12.3970-3972.2003","article-title":"Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans","volume":"47","author":"Lasala","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1021\/bc2000403","article-title":"Pseudosaccharide functionalized dendrimers as potent inhibitors of DC-SIGN dependent Ebola pseudotyped viral infection","volume":"22","author":"Luczkowiak","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"E4133","DOI":"10.1073\/pnas.1600299113","article-title":"Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose","volume":"113","author":"Chahal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1021\/ja953729u","article-title":"Polyacrylamides bearing pendant \u03b1-sialoside groups strongly inhibit agglutination of erythrocytes by influenza virus: The strong inhibition reflects enhanced binding through cooperative polyvalent interactions","volume":"118","author":"Sigal","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1021\/jo972061u","article-title":"Practical Synthesis of Starburst PAMAM \u03b1-Thiosialodendrimers for Probing Multivalent Carbohydrate\u2014Lectin Binding Properties","volume":"63","author":"Zanini","year":"1998","journal-title":"J. Org. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"G\u00fcnther, S.C., Maier, J.D., Vetter, J., Podvalnyy, N., Khanzhin, N., Hennet, T., and Stertz, S. (2020). Antiviral potential of 3\u2032-sialyllactose- and 6\u2032-sialyllactose-conjugated dendritic polymers against human and avian influenza viruses. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-57608-4"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1021\/jm5007676","article-title":"Synthesis and influenza virus inhibitory activities of carbosilane dendrimers peripherally functionalized with hemagglutinin-binding Peptide","volume":"57","author":"Hatano","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1086\/344316","article-title":"Prevention of influenza pneumonitis by sialic Acid-conjugated dendritic polymers","volume":"186","author":"Landers","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1099\/0022-1317-69-6-1137","article-title":"Interaction of polylysine with the cellular receptor for herpes simplex virus type 1","volume":"69 Pt 6","author":"Langeland","year":"1988","journal-title":"J. Gen. Virol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/viro.1999.9723","article-title":"The polysulfonated compound suramin blocks adsorption and lateral difusion of herpes simplex virus type-1 in vero cells","volume":"258","author":"Aguilar","year":"1999","journal-title":"Virology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1128\/AAC.00149-11","article-title":"Inhibition of herpes simplex virus type 1 and type 2 infections by peptide-derivatized dendrimers","volume":"55","author":"Luganini","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_120","first-page":"521","article-title":"Dendrimers functionalized with membrane-interacting peptides for viral inhibition","volume":"8","author":"Tarallo","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"13678","DOI":"10.1002\/chem.201202358","article-title":"Dendrimer functionalization with a membrane-interacting domain of herpes simplex virus type 1: Towards intracellular delivery","volume":"18","author":"Carberry","year":"2012","journal-title":"Chemistry"},{"key":"ref_122","first-page":"2147","article-title":"Prevention of vaginal and rectal herpes simplex virus type 2 transmission in mice: Mechanism of antiviral action","volume":"11","author":"Maly","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"46755","DOI":"10.1039\/C6RA06969J","article-title":"Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate","volume":"6","author":"Maly","year":"2016","journal-title":"RSC Adv."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.nano.2016.08.018","article-title":"Polyanionic carbosilane dendrimers prevent hepatitis C virus infection in cell culture","volume":"13","author":"Majano","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"16921","DOI":"10.1039\/C5NR02898A","article-title":"A galactose-functionalized dendritic siRNA-nanovector to potentiate hepatitis C inhibition in liver cells","volume":"7","author":"Lakshminarayanan","year":"2015","journal-title":"Nanoscale"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.nano.2009.12.001","article-title":"Dendrosome-based delivery of siRNA against E6 and E7 oncogenes in cervical cancer","volume":"6","author":"Dutta","year":"2010","journal-title":"Nanomedicine"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1021\/acs.jpcb.5b11125","article-title":"IL-6 Antibody and RGD Peptide Conjugated Poly(amidoamine) Dendrimer for Targeted Drug Delivery of HeLa Cells","volume":"120","author":"Mekuria","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1021\/bc025577f","article-title":"Synthetic approaches to multivalent lipopeptide dendrimers containing cyclic disulfide epitopes of foot-and-mouth disease virus","volume":"14","author":"Giralt","year":"2003","journal-title":"Bioconjug. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1074-5521(01)00042-4","article-title":"RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein","volume":"8","author":"Razinkov","year":"2001","journal-title":"Chem. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nbt995","article-title":"Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation","volume":"22","author":"Shaunak","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/emmm.201201290","article-title":"Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers","volume":"4","author":"Teo","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/1439-7633(20020902)3:9<836::AID-CBIC836>3.0.CO;2-2","article-title":"Inhibition of adhesion of type 1 fimbriated Escherichia coli to highly mannosylated ligands","volume":"3","author":"Nagahori","year":"2002","journal-title":"Chembiochem"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijpharm.2010.05.030","article-title":"Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers","volume":"395","author":"Wang","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1021\/bm0055495","article-title":"Quaternary ammonium functionalized poly(propylene imine) dendrimers as effective antimicrobials: Structure-activity studies","volume":"1","author":"Chen","year":"2000","journal-title":"Biomacromolecules"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3390\/toxins7030974","article-title":"Cholera toxin B: One subunit with many pharmaceutical applications","volume":"7","author":"Baldauf","year":"2015","journal-title":"Toxins"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1039\/b405344c","article-title":"Synthesis and cholera toxin binding properties of multivalent GM1 mimics","volume":"2","author":"Arosio","year":"2004","journal-title":"Org. Biomol. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1002\/1099-0690(200112)2001:24<4685::AID-EJOC4685>3.0.CO;2-9","article-title":"Synthesis of Lactose Dendrimers and Multivalency Effects in Binding to the Cholera Toxin B Subunit","volume":"2001","author":"Vrasidas","year":"2001","journal-title":"Eur. J. Org. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0006-2952(98)00198-1","article-title":"Inhibition of the adherence of cholera toxin and the heat-labile enterotoxin of Escherichia coli to cell-surface GM1 by oligosaccharide-derivatized dendrimers","volume":"56","author":"Thompson","year":"1998","journal-title":"Biochem. Pharm."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"10","DOI":"10.18433\/jpps29659","article-title":"PAMAM-dendrimer Enhanced Antibacterial Effect of Vancomycin Hydrochloride Against Gram-Negative Bacteria","volume":"22","author":"Serri","year":"2018","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1172\/JCI18535","article-title":"Antimicrobial resistance: The example of Staphylococcus aureus","volume":"111","author":"Lowy","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1586\/14787210.2014.859985","article-title":"Detection and clinical relevance of Staphylococcus aureus nasal carriage: An update","volume":"12","author":"Verhoeven","year":"2014","journal-title":"Expert. Rev. Anti-Infect. Ther."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1039\/c2nj40421d","article-title":"Antimicrobial activity of poly (propylene imine) dendrimers","volume":"36","author":"Felczak","year":"2012","journal-title":"New J. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1021\/acs.analchem.8b04870","article-title":"Rapid and Selective Discrimination of Gram-Positive and Gram-Negative Bacteria by Boronic Acid-Modified Poly(amidoamine) Dendrimer","volume":"91","author":"Tsuchido","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Sanz Del Olmo, N., Pe\u00f1a Gonz\u00e1lez, C.E., Rojas, J.D., G\u00f3mez, R., Ortega, P., Escarpa, A., and de la Mata, F.J. (2020). Antioxidant and Antibacterial Properties of Carbosilane Dendrimers Functionalized with Polyphenolic Moieties. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12080698"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Llamazares, C., Sanz Del Olmo, N., Ortega, P., G\u00f3mez, R., Soliveri, J., de la Mata, F.J., Garc\u00eda-Gallego, S., and Copa-Pati\u00f1o, J.L. (2019). Antibacterial Effect of Carbosilane Metallodendrimers in Planktonic Cells of Gram-Positive and Gram-Negative Bacteria and Staphylococcus aureus Biofilm. Biomolecules, 9.","DOI":"10.3390\/biom9090405"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Svenningsen, S.W., Frederiksen, R.F., Counil, C., Ficker, M., Leisner, J.J., and Christensen, J.B. (2020). Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate. Molecules, 25.","DOI":"10.3390\/molecules25061389"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2217\/fmb.11.3","article-title":"Redefining cerebral malaria by including malaria retinopathy","volume":"6","author":"Beare","year":"2011","journal-title":"Future Microbiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1086\/646611","article-title":"Malaria control, elimination, and eradication: The role of the evolving biomedical research agenda","volume":"200","author":"Hall","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Douglas, N.M., Anstey, N.M., Buffet, P.A., Poespoprodjo, J.R., Yeo, T.W., White, N.J., and Price, R.N. (2012). The anaemia of Plasmodium vivax malaria. Malar. J., 11.","DOI":"10.1186\/1475-2875-11-135"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1179\/146532810X12858955921032","article-title":"The impact of maternal malaria on newborns","volume":"30","author":"Hartman","year":"2010","journal-title":"Ann. Trop. Paediatr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cis.2013.10.014","article-title":"Advances in nanomedicines for malaria treatment","volume":"201\u2013202","author":"Aditya","year":"2013","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1016\/j.biomaterials.2014.05.061","article-title":"Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs","volume":"35","author":"Movellan","year":"2014","journal-title":"Biomaterials"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.1002\/chem.201800729","article-title":"Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action","volume":"24","author":"Hahn","year":"2018","journal-title":"Chemistry"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/0974-777X.62883","article-title":"Treatment of visceral leishmaniasis","volume":"2","author":"Moore","year":"2010","journal-title":"J. Glob. Infect. Dis."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1586\/eri.12.148","article-title":"Developments in diagnosis and treatment of visceral leishmaniasis during the last decade and future prospects","volume":"11","author":"Ejazi","year":"2013","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/jac\/dks275","article-title":"Miltefosine: A review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis","volume":"67","author":"Dorlo","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_157","first-page":"835","article-title":"Nanovaccine for leishmaniasis: Preparation of chitosan nanoparticles containing Leishmania superoxide dismutase and evaluation of its immunogenicity in BALB\/c mice","volume":"6","author":"Shokri","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/cei.12674","article-title":"Permissive and protective roles for neutrophils in leishmaniasis","volume":"182","author":"Carlsen","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Guerra, J.A., Prestes, S.R., Silveira, H., Coelho, L.I., Gama, P., Moura, A., Amato, V., Barbosa, M., and Ferreira, L.C. (2011). Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon. Plos Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0000980"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/QCO.0b013e328359eff2","article-title":"Recent advances in development of amphotericin B formulations for the treatment of visceral leishmaniasis","volume":"25","author":"Brocchini","year":"2012","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1473-3099(10)70011-6","article-title":"Combination therapy for visceral leishmaniasis","volume":"10","author":"Balasegaram","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e152","DOI":"10.1093\/cid\/cir674","article-title":"Limited effectiveness of high-dose liposomal amphotericin B (AmBisome) for treatment of visceral leishmaniasis in an Ethiopian population with high HIV prevalence","volume":"53","author":"Ritmeijer","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1016\/j.ijid.2011.03.021","article-title":"Recent advances in leishmaniasis treatment","volume":"15","author":"Tiuman","year":"2011","journal-title":"Int. J. Infect. Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.micinf.2013.04.005","article-title":"Proteomic analysis reveals differentially expressed proteins in macrophages infected with Leishmania amazonensis or Leishmania major","volume":"15","author":"Menezes","year":"2013","journal-title":"Microbes Infect."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.nano.2014.11.008","article-title":"Characterization and evaluation of amphotericin B loaded MDP conjugated poly(propylene imine) dendrimers","volume":"11","author":"Jain","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/infdis\/jit378","article-title":"A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis","volume":"208","author":"Daftarian","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1128\/AAC.04213-14","article-title":"Surface-engineered dendrimeric nanoconjugates for macrophage-targeted delivery of amphotericin B: Formulation development and in vitro and in vivo evaluation","volume":"59","author":"Jain","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1021\/jm3007596","article-title":"Salicylanilide inhibitors of Toxoplasma gondii","volume":"55","author":"Fomovska","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Behnke, M.S., Wootton, J.C., Lehmann, M.M., Radke, J.B., Lucas, O., Nawas, J., Sibley, L.D., and White, M.W. (2010). Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012354"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1021\/cr900327d","article-title":"Dendrimers designed for functions: From physical, photophysical, and supramolecular properties to applications in sensing, catalysis, molecular electronics, photonics, and nanomedicine","volume":"110","author":"Astruc","year":"2010","journal-title":"Chem. Rev."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1073\/pnas.1203516109","article-title":"Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum","volume":"109","author":"Augagneur","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"14182","DOI":"10.1073\/pnas.1208775109","article-title":"Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections","volume":"109","author":"Lai","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijpharm.2006.05.068","article-title":"Nanomolar cationic dendrimeric sulfadiazine as potential antitoxoplasmic agent","volume":"326","author":"Prieto","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1158\/0008-5472.CAN-04-3921","article-title":"Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer","volume":"65","author":"Candido","year":"2005","journal-title":"Cancer Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.2174\/1381612820666150827094341","article-title":"Dendrimers as an effective nanocarrier in cardiovascular disease","volume":"21","author":"Gothwal","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.progpolymsci.2013.07.005","article-title":"Dendrimer as nanocarrier for drug delivery","volume":"39","author":"Kesharwani","year":"2014","journal-title":"Prog. Polym. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijpharm.2010.04.027","article-title":"Dendrimer toxicity: Let\u2019s meet the challenge","volume":"394","author":"Jain","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.mattod.2015.06.003","article-title":"PAMAM dendrimers as promising nanocarriers for RNAi therapeutics","volume":"18","author":"Kesharwani","year":"2015","journal-title":"Mater. Today"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.polymer.2014.12.051","article-title":"Impact of pegylation on biopharmaceutical properties of dendrimers","volume":"59","author":"Thakur","year":"2015","journal-title":"Polymer"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1773-2247(05)50008-X","article-title":"PEGylated peptide-based dendritic nanoparticulate systems for delivery of artemether","volume":"15","author":"Bhadra","year":"2005","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"E536","DOI":"10.1208\/pt060367","article-title":"Poly (amidoamine)(PAMAM) dendritic nanostructures for controlled sitespecific delivery of acidic anti-inflammatory active ingredient","volume":"6","author":"Asthana","year":"2005","journal-title":"AAPS PharmSciTech"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-3659(99)00246-1","article-title":"Dendrimers:: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo","volume":"65","author":"Malik","year":"2000","journal-title":"J. Control. Release"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1016\/j.biomaterials.2014.03.064","article-title":"Generation dependent cancer targeting potential of poly (propyleneimine) dendrimer","volume":"35","author":"Kesharwani","year":"2014","journal-title":"Biomaterials"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.nano.2010.10.010","article-title":"Cancer targeting potential of some ligand-anchored poly (propylene imine) dendrimers: A comparison","volume":"7","author":"Kesharwani","year":"2011","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1007\/s11095-014-1549-2","article-title":"Generation dependent safety and efficacy of folic acid conjugated dendrimer based anticancer drug formulations","volume":"32","author":"Kesharwani","year":"2015","journal-title":"Pharm. Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0378-5173(00)00679-7","article-title":"Transport of poly amidoamine dendrimers across Madin\u2013Darby canine kidney cells","volume":"215","author":"Tajarobi","year":"2001","journal-title":"Int. J. Pharm."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1021\/bc049962b","article-title":"Interaction of poly (amidoamine) dendrimers with supported lipid bilayers and cells: Hole formation and the relation to transport","volume":"15","author":"Hong","year":"2004","journal-title":"Bioconjug. Chem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1021\/bm7008203","article-title":"Cytotoxicity of polypropylenimine dendrimer conjugates on cultured endothelial cells","volume":"8","author":"Stasko","year":"2007","journal-title":"Biomacromolecules"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1021\/bc900029k","article-title":"The role of ganglioside GM1 in cellular internalization mechanisms of poly (amidoamine) dendrimers","volume":"20","author":"Hong","year":"2009","journal-title":"Bioconjug. Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1021\/ma501258c","article-title":"Poly (ethylene glycol) corona chain length controls end-group-dependent cell interactions of dendron micelles","volume":"47","author":"Hsu","year":"2014","journal-title":"Macromolecules"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/mz300533w","article-title":"Positively charged dendron micelles display negligible cellular interactions","volume":"2","author":"Pearson","year":"2013","journal-title":"ACS Macro Lett."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Munro, N., Srinageshwar, B., Shalabi, F., Florendo, M., Otero, P., Thompson, C., Kippe, J., Malkowski, C., Climie, S., and Stewart, A.N. (2019). A novel approach to label bone marrow-derived mesenchymal stem cells with mixed-surface PAMAM dendrimers. Stem Cell Res. Ther., 10.","DOI":"10.1186\/s13287-019-1171-7"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Florendo, M., Figacz, A., Srinageshwar, B., Sharma, A., Swanson, D., Dunbar, G.L., and Rossignol, J. (2018). Use of Polyamidoamine Dendrimers in Brain Diseases. Molecules, 23.","DOI":"10.3390\/molecules23092238"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Srinageshwar, B., Peruzzaro, S., Andrews, M., Johnson, K., Hietpas, A., Clark, B., McGuire, C., Petersen, E., Kippe, J., and Stewart, A. (2017). PAMAM Dendrimers Cross the Blood-Brain Barrier When Administered through the Carotid Artery in C57BL\/6J Mice. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18030628"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/jmri.10025","article-title":"Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: Reference to pharmacokinetic properties of dendrimer-based MR contrast agents","volume":"14","author":"Kobayashi","year":"2001","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1021\/bm300316n","article-title":"Temporal control over cellular targeting through hybridization of folate-targeted dendrimers and PEG-PLA nanoparticles","volume":"13","author":"Sunoqrot","year":"2012","journal-title":"Biomacromolecules"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1021\/bc100484t","article-title":"Kinetically controlled cellular interactions of polymer\u2212 polymer and polymer\u2212 liposome nanohybrid systems","volume":"22","author":"Sunoqrot","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1021\/mp300560n","article-title":"In vitro evaluation of dendrimer\u2013polymer hybrid nanoparticles on their controlled cellular targeting kinetics","volume":"10","author":"Sunoqrot","year":"2013","journal-title":"Mol. Pharm."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.jaci.2015.10.034","article-title":"Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer","volume":"137","author":"Ganson","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Hershfield, M.S., Ganson, N.J., Kelly, S.J., Scarlett, E.L., Jaggers, D.A., and Sundy, J.S. (2014). Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients. Arthritis. Res. Ther., 16.","DOI":"10.1186\/ar4500"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1039\/c2cc37316e","article-title":"Orthogonality in organic, polymer, and supramolecular chemistry: From Merrifield to click chemistry","volume":"49","author":"Wong","year":"2013","journal-title":"Chem. Commun."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5","article-title":"Click chemistry: Diverse chemical function from a few good reactions","volume":"40","author":"Kolb","year":"2001","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.4103\/1673-5374.160063","article-title":"Dendrimer nanocarriers drug action: Perspective for neuronal pharmacology","volume":"10","author":"Vidal","year":"2015","journal-title":"Neural Regen. Res."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"De Stefano, D., Carnuccio, R., and Maiuri, M.C. (2012). Nanomaterials toxicity and cell death modalities. J. Drug Deliv., 2012.","DOI":"10.1155\/2012\/167896"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1515\/hsz-2017-0118","article-title":"Chronic viral hepatitis and its association with liver cancer","volume":"398","author":"Tu","year":"2017","journal-title":"Biol. Chem."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.canlet.2019.11.039","article-title":"Human papillomavirus vaccine against cervical cancer: Opportunity and challenge","volume":"471","author":"Wang","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/cas.13954","article-title":"Epstein-Barr virus strain variation and cancer","volume":"110","author":"Kanda","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-pathmechdis-012418-013023","article-title":"Epstein-Barr Virus and Cancer","volume":"14","author":"Farrell","year":"2019","journal-title":"Annu. Rev. Pathol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/ajcp\/103.3.308","article-title":"The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas","volume":"103","author":"Iezzoni","year":"1995","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Collatuzzo, G., Pelucchi, C., Negri, E., L\u00f3pez-Carrillo, L., Tsugane, S., Hidaka, A., Shigueaki Hamada, G., Hern\u00e1ndez-Ram\u00edrez, R.U., L\u00f3pez-Cervantes, M., and Malekzadeh, R. (2021). Exploring the interactions between Hp infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project. Int. J. Cancer.","DOI":"10.1002\/ijc.33678"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ccell.2018.03.004","article-title":"The Intestinal Microbiota in Colorectal Cancer","volume":"33","author":"Tilg","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1016\/j.biomaterials.2013.03.009","article-title":"Targeted CT\/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles","volume":"34","author":"Chen","year":"2013","journal-title":"Biomaterials"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1021\/acsami.6b04827","article-title":"(99m)Tc-Labeled Multifunctional Low-Generation Dendrimer-Entrapped Gold Nanoparticles for Targeted SPECT\/CT Dual-Mode Imaging of Tumors","volume":"8","author":"Li","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1039\/C7TB00543A","article-title":"A promising dual mode SPECT\/CT imaging platform based on (99m)Tc-labeled multifunctional dendrimer-entrapped gold nanoparticles","volume":"5","author":"Wen","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/21691401.2018.1430696","article-title":"(99m)Tc-labelled multifunctional polyethylenimine-entrapped gold nanoparticles for dual mode SPECT and CT imaging","volume":"46","author":"Zhao","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1021\/acsami.7b17107","article-title":"(99m)Tc-Labeled RGD-Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT\/CT Imaging of Hepatic Carcinoma","volume":"10","author":"Zhou","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.bmc.2011.01.036","article-title":"Radiosynthesis, biodistribution and micro-SPECT imaging study of dendrimer-avidin conjugate","volume":"19","author":"Xu","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1021\/jm901910j","article-title":"Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates","volume":"53","author":"Zhang","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1039\/c0dt01656j","article-title":"Multimodality and nanoparticles in medical imaging","volume":"40","author":"Huang","year":"2011","journal-title":"Dalton Trans."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1007\/s00330-020-06934-2","article-title":"Chest CT for detecting COVID-19: A systematic review and meta-analysis of diagnostic accuracy","volume":"30","author":"Xu","year":"2020","journal-title":"Eur. Radiol."},{"key":"ref_221","first-page":"68","article-title":"The Importance of Chest CT Scan in COVID-19","volume":"52","author":"Tenda","year":"2020","journal-title":"Acta Med. Indones."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1021\/nl020246x","article-title":"Novel iodinated dendritic nanoparticles for computed tomography (CT) imaging","volume":"2","author":"Yordanov","year":"2002","journal-title":"Nano Lett."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.1016\/j.biomaterials.2014.05.046","article-title":"Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles","volume":"35","author":"Zhu","year":"2014","journal-title":"Biomaterials"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.colsurfb.2015.05.040","article-title":"Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells","volume":"133","author":"Zhu","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1039\/c3md00050h","article-title":"Targeted cancer cell inhibition using multifunctional dendrimer-entrapped gold nanoparticles","volume":"4","author":"Zheng","year":"2013","journal-title":"MedChemComm"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1039\/b908397a","article-title":"Magnetic resonance imaging of chemistry","volume":"39","author":"Britton","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.apradiso.2015.07.021","article-title":"Radiolabeling optimization and characterization of (68)Ga labeled DOTA-polyamido-amine dendrimer conjugate\u2014Animal biodistribution and PET imaging results","volume":"105","author":"Ghai","year":"2015","journal-title":"Appl. Radiat. Isot."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1021\/bc400347s","article-title":"(64)Cu-labeled LyP-1-dendrimer for PET-CT imaging of atherosclerotic plaque","volume":"25","author":"Seo","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"19798","DOI":"10.1021\/acsami.5b05836","article-title":"Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131I for Single Photon Emission Computed Tomography Imaging and Radiotherapy of Gliomas","volume":"7","author":"Zhao","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Darvish Mohamadi, T., Amanlou, M., Ghalandarlaki, N., Mehravi, B., Shafiee Ardestani, M., and Yaghmaei, P. (2013). Gd(3+)-DTPA-Meglumine-Anionic Linear Globular Dendrimer G1: Novel Nanosized Low Toxic Tumor Molecular MR Imaging Agent. ISRN Pharm., 2013.","DOI":"10.1155\/2013\/378452"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"95112","DOI":"10.1039\/C6RA18718H","article-title":"Dendrimer-functionalized LAPONITE\u00ae nanodisks loaded with gadolinium for T 1-weighted MR imaging applications","volume":"6","author":"Mustafa","year":"2016","journal-title":"RSC Adv."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1111\/j.1523-1755.2005.00321.x","article-title":"Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice","volume":"67","author":"Dear","year":"2005","journal-title":"Kidney Int."},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Zhang, S., Lloveras, V., Pulido, D., Liko, F., Pinto, L.F., Albericio, F., Royo, M., and Vidal-Gancedo, J. (2020). Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12080772"},{"key":"ref_234","first-page":"271","article-title":"Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent","volume":"63","author":"Kobayashi","year":"2003","journal-title":"Cancer Res."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1021\/am508983n","article-title":"Conjugation of iron oxide nanoparticles with RGD-modified dendrimers for targeted tumor MR imaging","volume":"7","author":"Yang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.colsurfb.2019.05.050","article-title":"Dendronized magnetic nanoparticles for HIV-1 capture and rapid diagnostic","volume":"181","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.1021\/ja078176p","article-title":"Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging","volume":"130","author":"Alric","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1016\/j.bmcl.2010.02.002","article-title":"Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent","volume":"20","author":"Park","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Kim, D., Yu, M.K., Lee, T.S., Park, J.J., Jeong, Y.Y., and Jon, S. (2011). Amphiphilic polymer-coated hybrid nanoparticles as CT\/MRI dual contrast agents. Nanotechnology, 22.","DOI":"10.1088\/0957-4484\/22\/15\/155101"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/cmmi.376","article-title":"A fluorescent, paramagnetic and PEGylated gold\/silica nanoparticle for MRI, CT and fluorescence imaging","volume":"5","author":"Cormode","year":"2010","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1021\/bm100251s","article-title":"Synthesis and characterization of dual modality (CT\/MRI) core-shell microparticles for embolization purposes","volume":"11","author":"Hagit","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1002\/smll.201500856","article-title":"Dendrimer-Assisted Formation of Fe3O4\/Au Nanocomposite Particles for Targeted Dual Mode CT\/MR Imaging of Tumors","volume":"11","author":"Cai","year":"2015","journal-title":"Small"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1021\/acs.analchem.5b00135","article-title":"Multifunctional dendrimer-entrapped gold nanoparticles modified with RGD peptide for targeted computed tomography\/magnetic resonance dual-modal imaging of tumors","volume":"87","author":"Chen","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1021\/cm101036a","article-title":"Polymer-stabilized lanthanide fluoride nanoparticle aggregates as contrast agents for magnetic resonance imaging and computed tomography","volume":"22","author":"Cheung","year":"2010","journal-title":"Chem. Mater."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/cmmi.223","article-title":"A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents","volume":"3","author":"Regino","year":"2008","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.biomaterials.2012.11.010","article-title":"Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT\/MR imaging applications","volume":"34","author":"Wen","year":"2013","journal-title":"Biomaterials"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s10118-013-1242-7","article-title":"188Re-Labeled hyperbranched polysulfonamine as a robust tool for targeted cancer diagnosis and radioimmunotherapy","volume":"3","author":"Li","year":"2013","journal-title":"Chin. J. Polym. Sci."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1002\/adma.201000369","article-title":"Self-assembly of hyperbranched polymers and its biomedical applications","volume":"22","author":"Zhou","year":"2010","journal-title":"Adv. Mater."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/adma.200902144","article-title":"Dendritic polyglycerols for biomedical applications","volume":"22","author":"Quadir","year":"2010","journal-title":"Adv. Mater."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1021\/bc200010w","article-title":"Photoluminescent hyperbranched poly(amido amine) containing \u03b2-cyclodextrin as a nonviral gene delivery vector","volume":"22","author":"Chen","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3181\/0702-RM-33","article-title":"In Vivo evaluation of a PAMAM-cystamine-(Gd-DO3A) conjugate as a biodegradable macromolecular MRI contrast agent","volume":"232","author":"Xu","year":"2007","journal-title":"Exp. Biol. Med."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jconrel.2016.01.036","article-title":"High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives","volume":"226","author":"You","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1016\/j.biomaterials.2011.01.001","article-title":"Computed tomography imaging of cancer cells using acetylated dendrimer-entrapped gold nanoparticles","volume":"32","author":"Wang","year":"2011","journal-title":"Biomaterials"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jconrel.2017.01.010","article-title":"First in vivo MRI study on theranostic dendrimersomes","volume":"248","author":"Filippi","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Ortega, M., Guzm\u00e1n Merino, A., Fraile-Mart\u00ednez, O., Recio-Ruiz, J., Pekarek, L., Guijarro, L.G., Garc\u00eda-Honduvilla, N., \u00c1lvarez-Mon, M., Buj\u00e1n, J., and Garc\u00eda-Gallego, S. (2020). Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12090874"},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Yeo, S.J., Huong, D.T., Han, J.H., Kim, J.Y., Lee, W.J., Shin, H.J., Han, E.T., and Park, H. (2014). Performance of coumarin-derived dendrimer-based fluorescence-linked immunosorbent assay (FLISA) to detect malaria antigen. Malar. J., 13.","DOI":"10.1186\/1475-2875-13-266"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1039\/C8AN00941D","article-title":"Poly(amidoamine)-coated magnetic particles for enhanced detection of Schistosoma circulating anodic antigen in endemic urine samples","volume":"144","author":"Markwalter","year":"2018","journal-title":"Analyst"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/11\/3304\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:09:20Z","timestamp":1760162960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/11\/3304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":257,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["molecules26113304"],"URL":"https:\/\/doi.org\/10.3390\/molecules26113304","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]}}}