{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:04:59Z","timestamp":1760234699790,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Silesia in Katowice","award":["No. PCN-1-191\/K\/0\/F"],"award-info":[{"award-number":["No. PCN-1-191\/K\/0\/F"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Zinc is an effective anti-inflammatory and antioxidant trace element. The aim of this study was to analyse the protective effect of zinc and zinc\u2013prolactin systems as additives of preservation solutions in the prevention of nephron damage caused during ischemia. The study used a model for storing isolated porcine kidneys in Biolasol\u00ae. The solution was modified with the addition of Zn at a dose of 1 \u00b5g\/L and Zn: 1 \u00b5g\/L with prolactin (PRL): 0.1 \u00b5g\/L. After 2 h and 48 h of storage, the levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, sodium, potassium, creatinine and total protein were determined. Zinc added to the Biolasol\u00ae composition at a dose of 1 \u00b5g\/L showed minor effectiveness in the protection of nephrons. In turn, Zn2+ added to Biolasol + PRL (PRL: 0.1 \u00b5g\/L) acted as a prolactin inhibitor. We do not recommend the addition of Zn(II) (1 \u00b5g\/L) and Zn(II) (1 \u00b5g\/L) + PRL (0.1 \u00b5g\/L) to the Biolasol solution.<\/jats:p>","DOI":"10.3390\/molecules26113465","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T13:25:43Z","timestamp":1623072343000},"page":"3465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biochemical Studies in Perfundates and Homogenates of Isolated Porcine Kidneys after Flushing with Zinc or Zinc\u2013Prolactin Modified Preservation Solution Using a Static Cold Storage Technique"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-1370","authenticated-orcid":false,"given":"Aneta","family":"Ostr\u00f3\u017cka-Cie\u015blik","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-7417","authenticated-orcid":false,"given":"Barbara","family":"Doli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland"},{"name":"\u201cBiochefa\u201d Pharmaceutical Research and Production Plant, Kasztanowa 3, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Ryszka","sequence":"additional","affiliation":[{"name":"\u201cBiochefa\u201d Pharmaceutical Research and Production Plant, Kasztanowa 3, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"ref_1","first-page":"45","article-title":"Role of zinc in physiological and pathological processes of the body","volume":"50","author":"Gapys","year":"2014","journal-title":"J. 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