{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:33:35Z","timestamp":1782884015574,"version":"3.54.5"},"reference-count":16,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cusanuswerk","award":["No grant number; a personal fellowship"],"award-info":[{"award-number":["No grant number; a personal fellowship"]}]},{"name":"Apothekerstiftung Westfalen Lippe","award":["Grant title: Inhaltsstoffe pflanzlicher Arzneimittel als Leitstrukturen f\u00fcr neue Chemotherapeutica gegen vernachl\u00e4ssigte Tropenkrankheiten"],"award-info":[{"award-number":["Grant title: Inhaltsstoffe pflanzlicher Arzneimittel als Leitstrukturen f\u00fcr neue Chemotherapeutica gegen vernachl\u00e4ssigte Tropenkrankheiten"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a dichloromethane extract from Boswellia serrata resin. 11-keto-\u03b2-boswellic acid (KBA) could be isolated from these fractions and was tested in vitro against Leishmania donovani axenic amastigotes along with five further boswellic acid derivatives. 3-O-acetyl-11-keto-\u03b2-boswellic acid (AKBA) showed the strongest activity with an IC50 value of 0.88 \u00b5M against axenic amastigotes but was inactive against intracellular amastigotes in murine macrophages<\/jats:p>","DOI":"10.3390\/molecules26123651","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T21:24:29Z","timestamp":1623792269000},"page":"3651","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Boswellic Acids Show In Vitro Activity against Leishmania donovani"],"prefix":"10.3390","volume":"26","author":[{"given":"Hippolyt L.","family":"Greve","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Biology and Phytochemistry, University of M\u00fcnster, Pharma Campus\u2013Corrensstrasse 48, D-48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4051 Basel, Switzerland"},{"name":"University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-1941","authenticated-orcid":false,"given":"Pascal","family":"M\u00e4ser","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4051 Basel, Switzerland"},{"name":"University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-9705","authenticated-orcid":false,"given":"Thomas J.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biology and Phytochemistry, University of M\u00fcnster, Pharma Campus\u2013Corrensstrasse 48, D-48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.2174\/092986712800229087","article-title":"The Potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II","volume":"19","author":"Schmidt","year":"2012","journal-title":"Curr. 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