{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:14:54Z","timestamp":1779210894706,"version":"3.51.4"},"reference-count":165,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Key Research and development program of Zhejiang Province","award":["2018C02023"],"award-info":[{"award-number":["2018C02023"]}]},{"name":"the Research Foundation for the Taizhou Science and Technology Project","award":["1801ny05"],"award-info":[{"award-number":["1801ny05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Tea polyphenols (TPs) are the general compounds of natural polyhydroxyphenols extracted in tea. Although a large number of studies have shown that TPs have obvious neuroprotective and neuro repair effects, they are limited due to the low bioavailability in vivo. However, TPs can act indirectly on the central nervous system by affecting the \u201cmicroflora\u2013gut\u2013brain axis\u201d, in which the microbiota and its composition represent a factor that determines brain health. Bidirectional communication between the intestinal microflora and the brain (microbe\u2013gut\u2013brain axis) occurs through a variety of pathways, including the vagus nerve, immune system, neuroendocrine pathways, and bacteria-derived metabolites. This axis has been shown to influence neurotransmission and behavior, which is usually associated with neuropsychiatric disorders. In this review, we discuss that TPs and their metabolites may provide benefits by restoring the imbalance of intestinal microbiota and that TPs are metabolized by intestinal flora, to provide a new idea for TPs to play a neuroprotective role by regulating intestinal flora.<\/jats:p>","DOI":"10.3390\/molecules26123692","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T04:15:46Z","timestamp":1623903346000},"page":"3692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora"],"prefix":"10.3390","volume":"26","author":[{"given":"Zhicheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, College of Life Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Taizhou Biomedical Industry Research Institute Co., Ltd., Taizhou 317000, China"},{"name":"College of Life Sciences, Taizhou University, Taizhou 317000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junmin","family":"Li","sequence":"additional","affiliation":[{"name":"Taizhou Biomedical Industry Research Institute Co., Ltd., Taizhou 317000, China"},{"name":"College of Life Sciences, Taizhou University, Taizhou 317000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengxin","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, College of Life Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-9197","authenticated-orcid":false,"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.chom.2015.04.004","article-title":"Dynamics and stabilization of the human gut microbiome during the first year of life","volume":"17","author":"Backhed","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sarkar, A., Yoo, J.Y., Dutra, S.V.O., Morgan, K.H., and Groer, M. 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