{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:06:36Z","timestamp":1760234796002,"version":"build-2065373602"},"reference-count":118,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2019-111510RB-I00"],"award-info":[{"award-number":["PID2019-111510RB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Center \u2013 SONATA 15","award":["UMO-2019\/35\/D\/NZ7\/02830"],"award-info":[{"award-number":["UMO-2019\/35\/D\/NZ7\/02830"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Until recently, glia were considered to be a structural support for neurons, however further investigations showed that glial cells are equally as important as neurons. Among many different types of glia, enteric glial cells (EGCs) found in the gastrointestinal tract, have been significantly underestimated, but proved to play an essential role in neuroprotection, immune system modulation and many other functions. They are also said to be remarkably altered in different physiopathological conditions. A nutraceutical is defined as any food substance or part of a food that provides medical or health benefits, including prevention and treatment of the disease. Following the description of these interesting peripheral glial cells and highlighting their role in physiological and pathological changes, this article reviews all the studies on the effects of nutraceuticals as modulators of their functions. Currently there are only a few studies available concerning the effects of nutraceuticals on EGCs. Most of them evaluated molecules with antioxidant properties in systemic conditions, whereas only a few studies have been performed using models of gastrointestinal disorders. Despite the scarcity of studies on the topic, all agree that nutraceuticals have the potential to be an interesting alternative in the prevention and\/or treatment of enteric gliopathies (of systemic or local etiology) and their associated gastrointestinal conditions.<\/jats:p>","DOI":"10.3390\/molecules26123762","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T04:21:21Z","timestamp":1624249281000},"page":"3762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Nutraceuticals and Enteric Glial Cells"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-5703","authenticated-orcid":false,"given":"Laura","family":"L\u00f3pez-G\u00f3mez","sequence":"first","affiliation":[{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Department of Basic Health Sciences, University Rey Juan Carlos, 28933 Alcorc\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Szymaszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zieli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-8795","authenticated-orcid":false,"given":"Raquel","family":"Abalo","sequence":"additional","affiliation":[{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Department of Basic Health Sciences, University Rey Juan Carlos, 28933 Alcorc\u00f3n, Spain"},{"name":"Associated Unit to Institute of Medicinal Chemistry (Unidad Asociada I+D+i del Instituto de Qu\u00edmica M\u00e9dica, IQM), Spanish National Research Council (Consejo Superior de Investigaciones Cient\u00edficas, CSIC), 28006 Madrid, Spain"},{"name":"Working Group of Basic Sciences in Pain and Analgesia of the Spanish Pain Society (Grupo de Trabajo de Ciencias B\u00e1sicas en Dolor y Analgesia de la Sociedad Espa\u00f1ola del Dolor), 28022 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"ref_1","unstructured":"Seguella, L., and Gulbransen, B.D. 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