{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:54:37Z","timestamp":1791510877392,"version":"4.3.4"},"reference-count":90,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["20-15-00337"],"award-info":[{"award-number":["20-15-00337"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>CD47 is a receptor belonging to the immunoglobulin (Ig) superfamily and broadly expressed on cell membranes. Through interactions with ligands such as SIRP\u03b1, TSP-1, integrins, and SH2-domain bearing protein tyrosine phosphatase substrate-1 (SHPS-1), CD47 regulates numerous functions like cell adhesion, proliferation, apoptosis, migration, homeostasis, and the immune system. In this aspect, previous research has shown that CD47 modulates phagocytosis via macrophages, the transmigration of neutrophils, and the activation of T-cells, dendritic cells, and B-cells. Moreover, several studies have reported the increased expression of the CD47 receptor in a variety of diseases, including acute lymphoblastic leukemia (ALL), chronic myeloid leukemia, non-Hodgkin\u2019s lymphoma (NHL), multiple myeloma (MM), bladder cancer, acute myeloid leukemia (AML), Gaucher disease, Multiple Sclerosis and stroke among others. The ubiquitous expression of the CD47 cell receptor on most resident cells of the CNS has previously been established through different methodologies. However, there is little information concerning its precise functions in the development of different neurodegenerative pathologies in the CNS. Consequently, further research pertaining to the specific functions and roles of CD47 and SIRP is required prior to its exploitation as a druggable approach for the targeting of various neurodegenerative diseases that affect the human population. The present review attempts to summarize the role of both CD47 and SIRP and their therapeutic potential in neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/molecules26133943","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T11:45:40Z","timestamp":1624880740000},"page":"3943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways"],"prefix":"10.3390","volume":"26","author":[{"given":"Seyed Mohammad","family":"Gheibihayat","sequence":"first","affiliation":[{"name":"Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd 8916188635, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Cabezas","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Universidad Antonio Nari\u00f1o, Bogot\u00e1 111511, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita G.","family":"Nikiforov","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, Tsyurupa Street, 117418 Moscow, Russia"},{"name":"Laboratory of Medical Genetics, Institute of Experimental Cardiology, National Medical Research Center of Cardiology, 121552 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannaz","family":"Jamialahmadi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan 19395\/1495, Iran"},{"name":"Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 13944-91388, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64131, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 13944-91388, Iran"},{"name":"Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 13944-91388, Iran"},{"name":"School of Medicine, The University of Western Australia, Perth 6907, Australia"},{"name":"School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 13944-91388, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/19768354.2020.1818618","article-title":"CD47 (Cluster of differentiation 47): An anti-phagocytic receptor with a multitude of signaling functions","volume":"24","author":"Leclair","year":"2020","journal-title":"Anim. 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