{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:52:13Z","timestamp":1789509133110,"version":"build-2803163510"},"reference-count":177,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Vascular wilt caused by F. oxysporum (FOX) is one of the main limitations of producing several agricultural products worldwide, causing economic losses between 40% and 100%. Various methods have been developed to control this phytopathogen, such as the cultural, biological, and chemical controls, the latter being the most widely used in the agricultural sector. The treatment of this fungus through systemic fungicides, although practical, brings problems because the agrochemical agents used have shown mutagenic effects on the fungus, increasing the pathogen\u2019s resistance. The design and the synthesis of novel synthetic antifungal agents used against FOX have been broadly studied in recent years. This review article presents a compendium of the synthetic methodologies during the last ten years as promissory, which can be used to afford novel and potential agrochemical agents. The revision is addressed from the structural core of the most active synthetic compounds against FOX. The synthetic methodologies implemented strategies based on cyclo condensation reactions, radical cyclization, electrocyclic closures, and carbon\u2013carbon couplings by metal\u2013organic catalysis. This revision contributes significantly to the organic chemistry, supplying novel alternatives for the use of more effective agrochemical agents against F. oxysporum.<\/jats:p>","DOI":"10.3390\/molecules26133997","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T10:03:19Z","timestamp":1625047399000},"page":"3997","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Compendium of the Most Promising Synthesized Organic Compounds against Several Fusarium oxysporum Species: Synthesis, Antifungal Activity, and Perspectives"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-9629","authenticated-orcid":false,"given":"Paola","family":"Borrego-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Bioorganic Chemistry Laboratory, Facultad de Ciencias B\u00e1sicas y Aplicadas, Campus Nueva Granada, Universidad Militar, Nueva Granada, Cajic\u00e1 250247, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Ospina","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Laboratory, Facultad de Ciencias B\u00e1sicas y Aplicadas, Campus Nueva Granada, Universidad Militar, Nueva Granada, Cajic\u00e1 250247, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-8200","authenticated-orcid":false,"given":"Diego","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Laboratory, Facultad de Ciencias B\u00e1sicas y Aplicadas, Campus Nueva Granada, Universidad Militar, Nueva Granada, Cajic\u00e1 250247, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-micro-092412-155650","article-title":"Fusarium pathogenomics","volume":"67","author":"Ma","year":"2013","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1364-3703.2011.00783.x","article-title":"The Top 10 fungal pathogens in molecular plant pathology","volume":"13","author":"Dean","year":"2012","journal-title":"Mol. Plant Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1094\/PHYTO-96-0660","article-title":"A review of Fusarium milt of oil palm caused by Fusarium oxysporum f. sp. elaeidis","volume":"96","author":"Flood","year":"2007","journal-title":"Phytopathology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"23970","DOI":"10.3390\/ijms161023970","article-title":"The role of pathogen-secreted proteins in fungal vascular wilt diseases","volume":"16","author":"Rep","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cropro.2015.01.007","article-title":"Management of Fusarium wilt of banana: A review with special reference to tropical race 4","volume":"73","author":"Ploetz","year":"2015","journal-title":"Crop Prot."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.hpj.2018.08.001","article-title":"Banana Fusarium wilt (Fusarium oxysporum f. sp. cubense) control and resistance, in the context of developing wilt-resistant bananas within sustainable production systems","volume":"4","author":"Sijun","year":"2018","journal-title":"Hortic. Plant J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3389\/fmicb.2019.00616","article-title":"Biological control agents against Fusarium wilt of banana","volume":"10","author":"Bubici","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1071\/AR9960637","article-title":"Fusarium wilt of banana in Australia: A review","volume":"47","author":"Pegg","year":"1996","journal-title":"Aust. J. Agric. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/09670874.2015.1043972","article-title":"Fusarium wilt of banana: Biology, epidemiology and management","volume":"61","author":"Ghag","year":"2015","journal-title":"Int. J. Pest Manag."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.sjbs.2019.06.002","article-title":"Fusarium oxysporum f. sp. lycopersici causal agent of vascular wilt disease of tomato: Biology to diversity\u2014A review","volume":"26","author":"Srinivas","year":"2019","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_11","first-page":"1","article-title":"Pest categorisation of Fusarium oxysporum f. sp. albedinis","volume":"16","author":"Jeger","year":"2018","journal-title":"EFSA J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biocontrol.2016.06.004","article-title":"Biological control of ornamental plant diseases caused by Fusarium oxysporum: A review","volume":"101","author":"Lecomte","year":"2016","journal-title":"Biol. Control"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10681-015-1532-y","article-title":"Resistance sources, resistance screening techniques and disease management for Fusarium wilt in cotton","volume":"207","author":"Sanogo","year":"2016","journal-title":"Euphytica"},{"key":"ref_14","first-page":"1","article-title":"Association analysis for disease resistance to Fusarium oxysporum in cape gooseberry (Physalis peruviana L)","volume":"17","author":"Mueller","year":"2016","journal-title":"BMC Genom."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.micres.2017.05.001","article-title":"Fusarium infection causes genotoxic disorders and antioxidant-based damages in Orobanche spp.","volume":"201","author":"Aybeke","year":"2017","journal-title":"Microbiol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-4939-6707-0_4","article-title":"Fusarium species and their associated mycotoxins","volume":"Volume 1542","author":"Munkvold","year":"2017","journal-title":"Mycotoxigenic Fungi: Methods and Protocols, Methods in Molecular Biology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.plaphy.2017.06.028","article-title":"Role of fusaric acid in the development of \u2018Fusarium wilt\u2019 symptoms in tomato: Physiological, biochemical and proteomic perspectives","volume":"118","author":"Singh","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00001432-200004000-00005","article-title":"Fusarium infections of the skin","volume":"13","author":"Gupta","year":"2000","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s10096-013-1924-7","article-title":"Fusariosis, a complex infection caused by a high diversity of fungal species refractory to treatment","volume":"32","author":"Guarro","year":"2013","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s11046-018-0257-6","article-title":"Infections caused by Fusarium species in pediatric cancer patients and review of published literature","volume":"183","author":"Arnoni","year":"2018","journal-title":"Mycopathologia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1470-9465.2004.00845.x","article-title":"Human fusariosis","volume":"10","author":"Dignani","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.soilbio.2007.07.002","article-title":"Trichoderma-plant-pathogen interactions","volume":"40","author":"Vinale","year":"2008","journal-title":"Soil Biol. Biochem."},{"key":"ref_23","first-page":"133","article-title":"Molecular mechanism of Trichoderma as bio-control agents against phytopathogen system-a review","volume":"1","author":"Gajera","year":"2013","journal-title":"Curr. Res. Microbiol. Biotechnol."},{"key":"ref_24","unstructured":"Antoun, H., and Pr\u00e9vost, D. (2005). Ecology of plant growth promoting rhizobacteria. PGPR: Biocontrol and Biofertilization, Springer."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1094\/PHYTO-08-18-0320-RVW","article-title":"Current status of Fusarium oxysporum formae speciales and races","volume":"109","author":"Lecomte","year":"2019","journal-title":"Phytopathology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.pbi.2010.04.004","article-title":"The genomic organization of plant pathogenicity in Fusarium species","volume":"13","author":"Rep","year":"2010","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3389\/fpls.2018.01468","article-title":"Fusarium wilt of banana: Current knowledge on epidemiology and research needs toward sustainable disease management","volume":"9","author":"Dita","year":"2018","journal-title":"Front. Plant Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10681-013-0904-4","article-title":"Breeding melon for resistance to Fusarium wilt: Recent developments","volume":"192","author":"Oumouloud","year":"2013","journal-title":"Euphytica"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.cropro.2007.01.008","article-title":"Smallholder vegetable farmers in Northern Tanzania: Pesticides use practices, perceptions, cost and health effects","volume":"26","author":"Ngowi","year":"2007","journal-title":"Crop Prot."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/135479","article-title":"Phytotoxicity: An overview of the physiological responses of plants exposed to fungicides","volume":"2012","author":"Dias","year":"2012","journal-title":"J. Bot."},{"key":"ref_31","first-page":"1101","article-title":"Pesticide toxicity: A mechanistic approach","volume":"17","author":"Lushchak","year":"2018","journal-title":"EXCLI J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"14379","DOI":"10.1021\/acs.est.7b02723","article-title":"Can toxicokinetic and toxicodynamic modeling be used to understand and predict synergistic interactions between chemicals?","volume":"51","author":"Cedergreen","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1556\/ABiol.65.2014.1.10","article-title":"In vitro antifugal activity of medicinal plant extract against Fusarium oxysporum f. sp. lycopersici race 3 the causal agent of tomato wilt","volume":"65","author":"Isaac","year":"2014","journal-title":"Acta Biol. Hung."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/10286020902942350","article-title":"Natural products\u2014Antifungal agents derived from plants","volume":"11","author":"Arif","year":"2009","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1572-5995(01)80009-0","article-title":"Labdane-type diterpenes: Chemistry and biological activity","volume":"25","author":"Demetzos","year":"2001","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1016\/j.ejmech.2010.06.029","article-title":"Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide","volume":"45","author":"Zapata","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.lfs.2005.12.007","article-title":"Multiple biological activities of curcumin: A short review","volume":"78","author":"Maheshwari","year":"2006","journal-title":"Life Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"20186","DOI":"10.3390\/molecules201119684","article-title":"Synthesis of novel \u03b2-keto-enol derivatives tethered pyrazole, pyridine and furan as new potential antifungal and anti-breast cancer agents","volume":"20","author":"Radi","year":"2015","journal-title":"Molecules"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1021\/acs.jafc.7b01792","article-title":"Structure and activity relationship of curcumin: Role of methoxy group in anti-inflammatory and anti-colitis effects of curcumin","volume":"65","author":"Yang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"13710","DOI":"10.1021\/acsomega.9b01098","article-title":"Ultrasound-assisted synthesis, antifungal activity against Fusarium oxysporum, and three-dimensional quantitative structure\u2212activity relationship of N,S-Dialkyl dithiocarbamates derived from 2-amino acids","volume":"4","author":"Quiroga","year":"2019","journal-title":"ACS Omega"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/molecules13051111","article-title":"A convenient synthesis of amino acid methyl esters","volume":"13","author":"Li","year":"2008","journal-title":"Molecules"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"152382","DOI":"10.1016\/j.tetlet.2020.152382","article-title":"Iodine mediated direct coupling of benzylic alcohols with dithiocarbamate anions: An easy access of S-benzyl dithiocarbamate esters under neat reaction condition","volume":"61","author":"Dutta","year":"2020","journal-title":"Tetrahedron Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1039\/C9QO00747D","article-title":"Applications of sulfuryl fluoride (SO2F2) in chemical transformations","volume":"6","author":"Lekkala","year":"2019","journal-title":"Org. Chem. Front."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bioorg.2018.08.001","article-title":"Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies","volume":"81","author":"Ravindar","year":"2018","journal-title":"Bioorg. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9430","DOI":"10.1002\/anie.201309399","article-title":"Sulfur(VI) fluoride exchange (SuFEx): Another good reaction for click chemistry","volume":"53","author":"Dong","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1021\/acs.jmedchem.9b01108","article-title":"Aryl-fluorosulfate-based Lysine covalent Pan-Inhibitors of apoptosis protein (IAP) antagonists with cellular efficacy","volume":"62","author":"Baggio","year":"2019","journal-title":"J. Med. Chem."},{"key":"ref_47","first-page":"61","article-title":"Synthesis and molecular modeling studies of novel tert-butyl 2, 4- disubstituted carboxamido phenylcarbamate derivatives and evaluation of their antimicrobial activity","volume":"6","author":"Pochampally","year":"2014","journal-title":"Pharma Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1021\/acs.joc.7b03175","article-title":"Synthesis of N-(Hetero)aryl carbamates via CuI\/MNAO catalyzed cross-coupling of (Hetero)aryl halides with potassium cyanate in alcohols","volume":"83","author":"Kumar","year":"2018","journal-title":"J. Org. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1002\/cctc.202000876","article-title":"Nickel-catalyzed synthesis of N-(Hetero)aryl carbamates from cyanate salts and phenols activated with cyanuric chloride","volume":"12","author":"Esmaeilpour","year":"2020","journal-title":"ChemCatChem"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.arabjc.2017.05.022","article-title":"Synthesis, antimicrobial activity and docking study of some novel 4-(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino derivatives carrying biologically active sulfonamide moiety","volume":"13","author":"Ghorab","year":"2020","journal-title":"Arab. J. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejmech.2013.06.018","article-title":"Synthesis and antifungal activity of terpenyl-1,4-naphthoquinone and 1,4-anthracenedione derivatives","volume":"67","author":"Castro","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1016\/j.bmcl.2016.07.033","article-title":"Synthesis, structure and antimicrobial evaluation of a new gossypol triazole conjugates functionalized with aliphatic chains and benzyloxy groups","volume":"26","author":"Pyta","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ejmech.2012.11.017","article-title":"Synthesis and antimicrobial activity of some new benzo and naphthonitrile derivatives","volume":"60","author":"Fadda","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.bmc.2005.10.050","article-title":"Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists","volume":"14","author":"Ohno","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1016\/j.bmcl.2017.08.017","article-title":"Synthesis, antimicrobial activity, structure-activity relationship and cytotoxic studies of a new series of functionalized (Z)-3-(2-oxo-2-substituted ethylidene)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-ones","volume":"27","author":"Sharma","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1021\/acs.jafc.7b05491","article-title":"Design, synthesis, and antifungal activities of 3-acyl thiotetronic acid derivatives: New fatty acid synthase inhibitors","volume":"66","author":"Lv","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2165\/00003088-198916060-00002","article-title":"Pharmacokinetics of the newer benzodiazepines","volume":"16","author":"Garzone","year":"1989","journal-title":"Clin. Pharmacokinet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1517\/13543784.2011.573477","article-title":"The development of pyrrolobenzodiazepines as antitumour agents","volume":"20","author":"Hartley","year":"2011","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1021\/cr100233r","article-title":"Chemistry and biology of multicomponent reactions","volume":"112","author":"Wang","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1134\/S107036321607029X","article-title":"Synthesis, antimicrobial evaluation, and docking studies of some novel benzofuran based analogues of chalcone and 1,4-benzodiazepine","volume":"86","author":"Shankar","year":"2016","journal-title":"Russ. J. Gen. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13065-017-0364-3","article-title":"Synthesis, anti-microbial activity, cytotoxicity of some novel substituted (5-(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone analogs","volume":"12","author":"Shankar","year":"2018","journal-title":"Chem. Cent. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.bmc.2016.01.058","article-title":"Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates","volume":"24","author":"Senerovic","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1002\/anie.201408487","article-title":"Molecular recognition in chemical and biological systems","volume":"54","author":"Persch","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.1016\/j.bmcl.2012.09.002","article-title":"Design, synthesis, spectral and biological evaluation of novel 1-allyl substituted 2,6-diphenylpiperidin-4-ones and its derivatives of oximes\/oxime ethers","volume":"22","author":"Narayanan","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1007\/s00044-015-1396-7","article-title":"Synthesis, characterization and molecular docking studies of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives as potential antimicrobial agents","volume":"24","author":"Ramesh","year":"2015","journal-title":"Med. Chem. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1016\/j.bmc.2006.06.048","article-title":"Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.","volume":"14","author":"Anuradha","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1016\/j.bmc.2009.05.051","article-title":"New furanoflavanoids, intestinal \u03b1-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.)","volume":"17","author":"Tiwari","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1246\/bcsj.76.635","article-title":"Deoxygenative dimerization of benzylic and allylic alcohols, and their ethers and esters using lanthanum metal and chlorotrimethylsilane in the presence of a catalytic amount of iodine and copper(I) iodide","volume":"76","author":"Nishino","year":"2003","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/np50080a018","article-title":"Calodenone, a new isobiflavonoid from ochna calodendron","volume":"55","author":"Messanga","year":"1992","journal-title":"J. Nat. Prod."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.2174\/1381612043382710","article-title":"Natural and synthetic coumarin derivatives with anti-inflammatory \/ antioxidant activities","volume":"10","author":"Fylaktakidou","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.micpath.2017.01.024","article-title":"Antifungal activity of umbelliferone derivatives: Synthesis and structure-activity relationships","volume":"104","author":"Pan","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0306-3623(95)02112-4","article-title":"Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential","volume":"27","author":"Hoult","year":"1996","journal-title":"Gen. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1007\/s00044-011-9785-z","article-title":"Synthesis, antimicrobial and DNA cleavage studies of some 4-aryloxymethylcoumarins obtained by reaction of 4-bromomethylcoumarins with bidentate nucleophiles","volume":"21","author":"Makandar","year":"2012","journal-title":"Med. Chem. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/ardp.19813140810","article-title":"Studies on Coumarins, I","volume":"314","author":"Kulkarni","year":"1981","journal-title":"Arch. Der Pharm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1039\/C7OB02941A","article-title":"FeCl3-catalyzed dimerization\/elimination of 1,1-diarylalkenes: Efficient synthesis of functionalized 4H-chromenes","volume":"16","author":"Ma","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1080\/00397911.2019.1631849","article-title":"Ultrasound assisted rapid synthesis, biological evaluation, and molecular docking study of new 1,2,3-triazolyl pyrano[2,3-c]pyrazoles as antifungal and antioxidant agent","volume":"49","author":"Khare","year":"2019","journal-title":"Synth. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"104792","DOI":"10.1016\/j.bioorg.2021.104792","article-title":"Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer\u2019s disease","volume":"110","author":"Amin","year":"2021","journal-title":"Bioorg. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9002","DOI":"10.1039\/C9NJ00703B","article-title":"A new efficient domino approach for the synthesis of coumarin-pyrazolines as antimicrobial agents targeting bacterial D-alanine-D-alanine ligase","volume":"43","author":"Chate","year":"2019","journal-title":"New J. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"105833","DOI":"10.1016\/j.clay.2020.105833","article-title":"Towards highly efficient hydrotalcite\/hydroxyapatite composites as novel catalysts involved in eco-synthesis of chromene derivatives","volume":"198","author":"Fetter","year":"2020","journal-title":"Appl. Clay Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"110458","DOI":"10.1016\/j.micromeso.2020.110458","article-title":"Propylsulfonic acid grafted on mesoporous siliceous FDU-5 material: A high TOF catalyst for the synthesis of coumarins via Pechmann condensation","volume":"307","author":"Gonzalez","year":"2020","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ejmech.2009.12.022","article-title":"Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin","volume":"45","author":"Basanagouda","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/17518253.2020.1737250","article-title":"Ultrasound assisted eco-friendly synthesis of 3-cinnamoyl coumarins using N,N\u2032-(1,2-phenylene)bis(2-aminobenzamide) dichloro cobalt immobilized on mesoporous Al-SBA-15 as a new and recyclable catalyst","volume":"13","author":"Akbarzadeh","year":"2020","journal-title":"Green Chem. Lett. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(02)00298-X","article-title":"The biochemistry and medical significance of the flavonoids","volume":"96","author":"Havsteen","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1039\/C7MD00209B","article-title":"Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents","volume":"8","author":"Chen","year":"2017","journal-title":"MedChemComm"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"113400","DOI":"10.1016\/j.ejmech.2021.113400","article-title":"An insight in anti-malarial potential of indole scaffold: A review","volume":"218","author":"Chauhan","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_86","first-page":"107746","article-title":"Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets","volume":"221","author":"Gobec","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.bmcl.2011.12.061","article-title":"An efficient synthesis of highly functionalized novel chromeno[4,3-b] pyrroles and indolizino[6,7-b]indoles as potent antimicrobial and antioxidant agents","volume":"22","author":"Arumugam","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.mencom.2011.07.008","article-title":"Intramolecular cyclization of O-(3,5-diaminophenyl)-substituted ketoximes as a route to 6-amino-4-hydroxyindoles","volume":"21","author":"Kokurkina","year":"2011","journal-title":"Mendeleev Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"6984","DOI":"10.1021\/cr2000459","article-title":"From 2000 to mid-2010: A fruitful decade for the synthesis of pyrazoles","volume":"111","author":"Fustero","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ejmech.2013.08.053","article-title":"Pyrazole containing natural products: Synthetic preview and biological significance","volume":"69","author":"Kumar","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"14036","DOI":"10.3390\/molecules190914036","article-title":"Design, synthesis and fungicidal activities of some novel pyrazole derivatives","volume":"19","author":"Liu","year":"2014","journal-title":"Molecules"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejmech.2012.07.029","article-title":"Design, synthesis, antimicrobial, anti-inflammatory and analgesic activity of novel isoxazolyl pyrimido[4,5-b]quinolines and isoxazolyl chromeno[2,3-d]pyrimidin-4-ones","volume":"55","author":"Rajanarendar","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jscs.2015.02.002","article-title":"Synthesis and antimicrobial studies of furyl based new bispyrazolines linked via aliphatic chains","volume":"21","author":"Yusuf","year":"2017","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1002\/jhet.3631","article-title":"New biphenyl-based bispyrazolines: Synthesis, antimicrobial, and docking studies","volume":"56","author":"Yusuf","year":"2019","journal-title":"J. Heterocycl. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.ejmech.2011.03.045","article-title":"Synthesis and antimicrobial activity of some new 4-hetarylpyrazole and furo[2,3-c]pyrazole derivatives","volume":"46","author":"Bondock","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1016\/j.ejmech.2010.04.029","article-title":"Conventional and microwave assisted synthesis of some new N-[(4-oxo-2-substituted aryl-1,3-thiazolidine)-acetamidyl]-5-nitroindazoles and its antimicrobial activity","volume":"45","author":"Upadhyay","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1016\/j.bmc.2012.09.013","article-title":"The therapeutic journey of benzimidazoles: A review","volume":"20","author":"Bansal","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0960-894X(02)01006-5","article-title":"Design, synthesis and biological evaluation of benzimidazole\/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors","volume":"13","author":"Paramashivappa","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00044-017-2085-5","article-title":"Imidazole-thiazole coupled derivatives as novel lanosterol 14-\u03b1 demethylase inhibitors: Ionic liquid mediated synthesis, biological evaluation and molecular docking study","volume":"27","author":"Nikalje","year":"2018","journal-title":"Med. Chem. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1007\/s00044-017-1888-8","article-title":"Synthesis, biological screening, POM, and 3D-QSAR analyses of some novel pyrazolic compounds","volume":"26","author":"Abrigach","year":"2017","journal-title":"Med. Chem. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.cclet.2016.03.014","article-title":"1,2,3-Triazole tethered acetophenones: Synthesis, bioevaluation and molecular docking study","volume":"27","author":"Shaikh","year":"2016","journal-title":"Chin. Chem. Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejmech.2013.04.045","article-title":"A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity","volume":"65","author":"Darandale","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Haj\u00f3s, G., Riedl, Z., and Kollenz, G. (2001). Recent advances in ring transformations of five-membered heterocycles and their fused derivatives. Eur. J. Org. Chem., 3405\u20133414.","DOI":"10.1002\/1099-0690(200109)2001:18<3405::AID-EJOC3405>3.0.CO;2-Y"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1016\/j.ejmech.2010.08.007","article-title":"Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1,3,4-thiadiazole derivatives","volume":"45","author":"Kadi","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1021\/cr400131u","article-title":"1,3,4-Thiadiazole: Synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry","volume":"114","author":"Hu","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.arabjc.2011.02.006","article-title":"Synthesis and biological significances of 1,3,4-thiadiazolines and related heterocyclic compounds","volume":"7","author":"Yusuf","year":"2014","journal-title":"Arab. J. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/jhet.2158","article-title":"Synthesis and antimicrobial evaluations of 1,3,4-thiadiazoline-based bisheterocyclics","volume":"52","author":"Yusuf","year":"2014","journal-title":"J. Heterocycl. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/17518253.2019.1646813","article-title":"Transalkylidation reaction: Green, catalyst-free synthesis of thiosemicarbazones and solving the NMR conflict between their acyclic structure and intramolecular cycloaddition products","volume":"12","author":"Omar","year":"2019","journal-title":"Green Chem. Lett. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/jhet.3487","article-title":"Efficient synthesis of some new 1,3,4-Thiadiazoles and 1,2,4-Triazoles kinked to pyrazolylcoumarin ring system as potent 5\u03b1-reductase inhibitors","volume":"56","author":"Gomha","year":"2019","journal-title":"J. Heterocycl. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1002\/jhet.3714","article-title":"Synthesis, characterization & in vitro antimicrobial-antioxidant studies of novel N,1-diphenyl-4,5-dihydro-1H-1,2,4-triazol-3-amine derivatives","volume":"56","author":"Yusuf","year":"2019","journal-title":"J. Heterocycl. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s00044-009-9283-8","article-title":"Combinatorial approach: Identification of potential antifungals from triazole minilibraries","volume":"20","author":"Bhatia","year":"2011","journal-title":"Med. Chem. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9129","DOI":"10.3390\/molecules16119129","article-title":"Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties","volume":"16","author":"Xu","year":"2011","journal-title":"Molecules"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"30848","DOI":"10.1039\/D0RA05886F","article-title":"Synthesis of 1,3,4-oxadiazoles derivatives with antidepressant activity and their binding to the 5-HT1Areceptor","volume":"10","author":"Wang","year":"2020","journal-title":"RSC Adv."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1002\/ejoc.202000311","article-title":"Electrochemical synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from \u03b1-keto acids and acylhydrazines under mild conditions","volume":"2020","author":"Lu","year":"2020","journal-title":"Eur. J. Org. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bmcl.2013.11.029","article-title":"Novel pyrazole integrated 1,3,4-oxadiazoles: Synthesis, characterization and antimicrobial evaluation","volume":"24","author":"Ningaiah","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13065-020-00717-y","article-title":"Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents","volume":"15","author":"Kumari","year":"2021","journal-title":"BMC Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12039-020-01872-4","article-title":"Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents","volume":"133","author":"Rishikesan","year":"2021","journal-title":"J. Chem. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1002\/jhet.3608","article-title":"Design and synthesis of new aryloxy-linked dimeric 1,2,3-triazoles via click chemistry approach: Biological evaluation and molecular docking study","volume":"56","author":"Deshmukh","year":"2019","journal-title":"J. Heterocycl. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cclet.2015.11.003","article-title":"1,2,3-Triazole incorporated coumarin derivatives as potential antifungal and antioxidant agents","volume":"27","author":"Shaikh","year":"2016","journal-title":"Chin. Chem. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1021\/jm950727b","article-title":"Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: Structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins","volume":"39","author":"Gazit","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"10268","DOI":"10.1021\/ja002112w","article-title":"Fluorinated calix[4]pyrrole and dipyrrolylquinoxaline: Neutral anion receptors with augmented affinities and enhanced selectivities","volume":"122","author":"Anzenbacher","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1021\/jm049952w","article-title":"Synthesis of new quinoxaline-2-carboxylate 1,4-dioxide derivatives as anti-Mycobacterium tuberculosis agents","volume":"48","author":"Jaso","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"103841","DOI":"10.1016\/j.bioorg.2020.103841","article-title":"Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies","volume":"99","author":"Ammar","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/1389557519666190617153213","article-title":"A Review on anticancer potentials of benzothiazole derivatives","volume":"20","author":"Pathak","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejmech.2014.10.059","article-title":"A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry","volume":"89","author":"Keri","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/2213337205666180119143539","article-title":"A Review on synthesis of benzothiazole derivatives","volume":"4","author":"Banerjee","year":"2017","journal-title":"Curr. Organocatal."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"10325","DOI":"10.1021\/acs.jafc.7b04130","article-title":"Green Synthesis of Potential Antifungal Agents: 2-Benzyl Substituted Thiobenzoazoles","volume":"65","author":"Ballari","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"29405","DOI":"10.1039\/C9RA04488D","article-title":"One-pot sequential synthesis and antifungal activity of 2-(benzylsulfonyl)benzothiazole derivatives","volume":"9","author":"Ballari","year":"2019","journal-title":"RSC Adv."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1016\/j.ejmech.2009.07.024","article-title":"Enaminonitrile in heterocyclic synthesis: Synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety","volume":"44","author":"Bondock","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1016\/j.ejmech.2010.05.018","article-title":"Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moiety","volume":"45","author":"Bondock","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1002\/jhet.3624","article-title":"Antimicrobial properties of some new synthesized benzothiazole linked carboxamide, acetohydrazide, and sulfonamide systems","volume":"56","author":"Fadda","year":"2019","journal-title":"J. Heterocycl. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1016\/j.bmcl.2017.05.032","article-title":"Synthesis, SAR and molecular docking studies of benzo[d]thiazole-hydrazones as potential antibacterial and antifungal agents","volume":"27","author":"Zha","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ejmech.2013.07.015","article-title":"Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4- ones; Synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones","volume":"69","author":"Puttaraju","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1007\/s00044-015-1322-z","article-title":"Synthesis, antimicrobial and antioxidant activities of imidazotriazoles and new multicomponent reaction toward 5-amino-1-phenyl[1,2,4]triazole derivatives","volume":"24","author":"Aouali","year":"2015","journal-title":"Med. Chem. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1248\/bpb.b15-00586","article-title":"Novel pyrazolo[3,4-b]pyridine derivatives: Synthesis, characterization, antimicrobial and antiproliferative profile","volume":"39","author":"Salem","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"ref_136","first-page":"687","article-title":"Synthesis, biological evaluation and docking studies of a new series of tris-heterocycles containing pyrazole, triazole and oxadiazole","volume":"57","author":"Kumar","year":"2018","journal-title":"Indian J. Chem. Sect. B Org. Med. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1007\/s00044-017-1990-y","article-title":"Synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine-3-carboxamide as antimicrobial agents","volume":"26","author":"Hassan","year":"2017","journal-title":"Med. Chem. Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1007\/s00044-013-0598-0","article-title":"Design, synthesis, antimicrobial, anti-inflammatory, and analgesic activity of novel dihydrobenzo furo[3,2-e]isoxazolo[4,5-b]azepin-5(5aH)-ones","volume":"22","author":"Rajanarendar","year":"2013","journal-title":"Med. Chem. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1007\/s00044-012-9978-0","article-title":"Synthesis, characterization and biological evaluation of some pyridine and quinoline fused chromenone derivatives","volume":"21","author":"Patel","year":"2012","journal-title":"Med. Chem. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11030-018-9859-7","article-title":"Expedient multicomponent synthesis of a small library of some novel highly substituted pyrido[2,3-d]pyrimidine derivatives mediated and promoted by deep eutectic solvent and in vitro and quantum mechanical study of their antibacterial and antifungal activities","volume":"23","author":"Aryan","year":"2019","journal-title":"Mol. Divers."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s13738-019-01766-4","article-title":"Synthesis, crystal structure, antimicrobial activity and docking studies of new imidazothiazole derivatives","volume":"17","author":"Koudad","year":"2020","journal-title":"J. Iran. Chem. Soc."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.bmcl.2010.10.120","article-title":"Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents","volume":"21","author":"Sangshetti","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00044-013-0728-8","article-title":"Eco-friendly synthesis and antimicrobial activities of substituted-5-(1H- indol-3-yl)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives","volume":"23","author":"Thirupathi","year":"2014","journal-title":"Med. Chem. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1016\/j.bmcl.2010.04.084","article-title":"Synthesis of novel \u03b2-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens","volume":"20","author":"Arumugam","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.bmcl.2016.03.045","article-title":"Novel tetrazoloquinoline-rhodanine conjugates: Highly efficient synthesis and biological evaluation","volume":"26","author":"Subhedar","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"115048","DOI":"10.1016\/j.bmc.2019.115048","article-title":"Synthesis and fungicidal activity of novel pyrazole derivatives containing 5-Phenyl-2-Furan","volume":"27","author":"Ahmed","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2174\/1570180814666170704101817","article-title":"Synthesis, biological evaluation, molecular docking study and acute oral toxicity study of coupled omidazole-pyrimidine derivatives","volume":"15","author":"Tiwari","year":"2018","journal-title":"Lett. Drug Des. Discov."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"105144","DOI":"10.1016\/j.tiv.2021.105144","article-title":"Novel podophyllotoxin and benzothiazole derivative induces transitional morphological and functional changes in HaCaT cells","volume":"73","author":"Strus","year":"2021","journal-title":"Toxicol. Vitr."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1134\/S1068162021030109","article-title":"Synthesis, Photophysical Properties, and Cytotoxicity of Rhodamine Based Fluorescent Probes","volume":"47","author":"Kumar","year":"2021","journal-title":"Russ. J. Bioorg. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"144304","DOI":"10.1016\/j.scitotenv.2020.144304","article-title":"UV\/chlorine process for degradation of benzothiazole and benzotriazole in water: Efficiency, mechanism and toxicity evaluation","volume":"760","author":"Yang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"142617","DOI":"10.1016\/j.scitotenv.2020.142617","article-title":"Contamination profiles and health impact of benzothiazole and its derivatives in PM2.5 in typical Chinese cities","volume":"755","author":"Liao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"116542","DOI":"10.1016\/j.watres.2020.116542","article-title":"Nontargeted identification and predicted toxicity of new byproducts generated from UV treatment of water containing micropollutant 2-mercaptobenzothiazole","volume":"188","author":"Jiang","year":"2021","journal-title":"Water Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00128-020-02954-2","article-title":"Photodegradation of Emerging Contaminant 2-(tiocyanomethylthio) Benzothiazole (TCMTB) in Aqueous Solution: Kinetics and Transformation Products","volume":"105","author":"Bertoldi","year":"2020","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"116625","DOI":"10.1016\/j.envpol.2021.116625","article-title":"Alkylated polycyclic aromatic hydrocarbons are the largest contributor to polycyclic aromatic compound concentrations in traditional foods of the Bigstone Cree Nation in Alberta, Canada","volume":"275","author":"Golzadeh","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.gene.2018.07.003","article-title":"Specific enzyme functionalities of Fusarium oxysporum compared to host plants","volume":"676","author":"Catharina","year":"2018","journal-title":"Gene"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2174\/1568012033483114","article-title":"Chitin Synthase as an Antifungal Target: Recent Advances","volume":"2","author":"Behr","year":"2003","journal-title":"Curr. Med. Chem. Anti-Infect. Agents"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1104\/pp.104.058248","article-title":"A Novel Short-Root Gene Encodes a Glucosamine-6-Phosphate Acetyltransferase Required for Maintaining Normal Root Cell Shape in Rice","volume":"138","author":"Jiang","year":"2005","journal-title":"Plant Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/wrna.15","article-title":"Regulation of mRNA decapping","volume":"1","author":"Li","year":"2010","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1099\/mic.0.2007\/014555-0","article-title":"Carnitine acetyltransferases are required for growth on non-fermentable carbon sources but not for pathogenesis in Candida albicans","volume":"154","author":"Zhou","year":"2008","journal-title":"Microbiology"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1021\/bi047353l","article-title":"Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis","volume":"44","author":"Zhang","year":"2005","journal-title":"Biochemistry"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrd870","article-title":"Endogenous kynurenines as targets for drug discovery and development","volume":"1","author":"Stone","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"50091","DOI":"10.1074\/jbc.M303828200","article-title":"Catalysis, Stereochemistry, and Inhibition of Ureidoglycolate Lyase","volume":"278","author":"McIninch","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"12390","DOI":"10.1074\/jbc.270.21.12390","article-title":"Translocation of Apocytochrome c across the Outer Membrane of Mitochondria","volume":"270","author":"Mayer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Yang, C., Hamel, C., Vujanovic, V., and Gan, Y. (2011). Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms. ISRN Ecol., 2011.","DOI":"10.5402\/2011\/130289"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1574-6968.2009.01645.x","article-title":"Sterol content analysis suggests altered eburicol 14\u03b1-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides","volume":"296","author":"Bean","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"140206","DOI":"10.1016\/j.bbapap.2019.02.008","article-title":"Fungal Lanosterol 14\u03b1-demethylase: A target for next-generation antifungal design","volume":"1868","author":"Monk","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) Proteins Proteom."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Cob-Calan, N.N., Chi-Uluac, L.A., Ortiz-Chi, F., Cerqueda-Garc\u00eda, D., Navarrete-V\u00e1zquez, G., Ruiz-S\u00e1nchez, E., and Hern\u00e1ndez-N\u00fa\u00f1ez, E. (2019). Molecular Docking and Dynamics Simulation of Protein \u03b2-Tubulin and Antifungal Cyclic Lipopeptides. Molecules, 24.","DOI":"10.3390\/molecules24183387"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1517\/13543776.2011.545349","article-title":"Microtubules as antifungal and antiparasitic drug targets","volume":"21","author":"Chatterji","year":"2011","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s002940050289","article-title":"Characterization of the mitochondrial cytochrome b gene from Venturia inaequalis","volume":"32","author":"Zheng","year":"1997","journal-title":"Curr. Genet."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0969-2126(00)00152-0","article-title":"Structure at 2.3 \u00c5 resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment","volume":"8","author":"Hunte","year":"2000","journal-title":"Structure"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ps.2074","article-title":"Characterization of the cytochrome b (cyt b) gene from Monilinia species causing brown rot of stone and pome fruit and its significance in the development of QoI resistance","volume":"67","author":"Hily","year":"2011","journal-title":"Pest Manag. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1054-3589(08)61140-0","article-title":"DNA Topoisomerase Inhibitors as Antifungal Agents","volume":"29","author":"Shen","year":"1994","journal-title":"Adv. Pharmacol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s00204-016-1855-z","article-title":"Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase","volume":"91","author":"Jarolim","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3389\/fmicb.2021.633036","article-title":"Drought Exposed Burkholderia seminalis JRBHU6 Exhibits Antimicrobial Potential through Pyrazine-1,4-Dione Derivatives Targeting Multiple Bacterial and Fungal Proteins","volume":"12","author":"Prasad","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"128527","DOI":"10.1016\/j.molstruc.2020.128527","article-title":"Design, synthesis, biological evaluation, molecular docking, DFT calculations and in silico ADME analysis of (benz)imidazole-hydrazone derivatives as promising antioxidant, antifungal, and anti-acetylcholinesterase agents","volume":"1218","author":"Boulebd","year":"2020","journal-title":"J. Mol. Struct."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/02772248.2020.1770253","article-title":"Fungicidal activity and molecular modeling of fusarubin analogues from Fusarium oxysporum","volume":"102","author":"Kundu","year":"2020","journal-title":"Toxicol. Environ. Chem."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"103619","DOI":"10.1016\/j.bioorg.2020.103619","article-title":"Design, synthesis, in vitro antimicrobial evaluation and molecular docking studies of indol-2-one tagged with morpholinosulfonyl moiety as DNA gyrase inhibitors","volume":"96","author":"Salem","year":"2020","journal-title":"Bioorg. Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/13\/3997\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:23:44Z","timestamp":1760163824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/13\/3997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":177,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["molecules26133997"],"URL":"https:\/\/doi.org\/10.3390\/molecules26133997","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}