{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:48:35Z","timestamp":1784371715123,"version":"3.55.0"},"reference-count":47,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Royal Golden Jubilee (RGJ) Ph.D. Scholarship, Thailand Science Research and Innovation","award":["PHD\/0210\/2557"],"award-info":[{"award-number":["PHD\/0210\/2557"]}]},{"name":"Medical Faculty Endowment Fund, Faculty of Medicine, Chiang Mai University, Thailand","award":["BIO-2563-07672"],"award-info":[{"award-number":["BIO-2563-07672"]}]},{"name":"British Council-Newton Fund through Miss Supawadee Maneekesorn","award":["BC-Newton Fund 2018"],"award-info":[{"award-number":["BC-Newton Fund 2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Malaria i a serious health problem caused by Plasmodium spp. that can be treated by an anti-folate pyrimethamine (PYR) drug. Deferiprone (DFP) is an oral iron chelator used for the treatment of iron overload and has been recognized for its potential anti-malarial activity. Deferiprone\u2013resveratrol hybrids (DFP-RVT) have been synthesized to present therapeutic efficacy at a level which is superior to DFP. We have focused on determining the lipophilicity, toxicity and inhibitory effects on P. falciparum growth and the iron-chelating activity of labile iron pools (LIPs) by DFP-RVT. According to our findings, DFP-RVT was more lipophilic than DFP (p &lt; 0.05) and nontoxic to blood mononuclear cells. Potency for the inhibition of P. falciparum was PYR &gt; DFP-RVT &gt; DFP in the 3D7 strain (IC50 = 0.05, 16.82 and 47.67 \u00b5M, respectively) and DFP-RVT &gt; DFP &gt; PYR in the K1 strain (IC50 = 13.38, 42.02 and 105.61 \u00b5M, respectively). The combined treatment of DFP-RVT with PYR additionally enhanced the PYR activity in both strains. DFP-RVT dose-dependently lowered LIP levels in PRBCs and was observed to be more effective than DFP at equal concentrations. Thus, the DFP-RVT hybrid should be considered a candidate as an adjuvant anti-malarial drug through the deprivation of cellular iron.<\/jats:p>","DOI":"10.3390\/molecules26134074","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T22:34:36Z","timestamp":1625438076000},"page":"4074","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Identifying a Deferiprone\u2013Resveratrol Hybrid as an Effective Lipophilic Anti-Plasmodial Agent"],"prefix":"10.3390","volume":"26","author":[{"given":"Supawadee","family":"Maneekesorn","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hataichanok","family":"Chuljerm","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakornsrithammarat 80160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimpisid","family":"Koonyosying","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chairat","family":"Uthaipibull","sequence":"additional","affiliation":[{"name":"National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani 12000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmin","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-8781","authenticated-orcid":false,"given":"Somdet","family":"Srichairatanakool","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dogovski, C., Xie, S.C., Burgio, G., Bridgford, J., Mok, S., McCaw, J.M., Chotivanich, K., Kenny, S., Gnadig, N., and Straimer, J. 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