{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:23:45Z","timestamp":1764588225026,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006472","name":"Universitatea de Medicina \u0219i Farmacie Grigore T. Popa - Iasi","doi-asserted-by":"publisher","award":["Internal Research Grant number 16407\u2014Project director Liliana Mititelu-Tartau"],"award-info":[{"award-number":["Internal Research Grant number 16407\u2014Project director Liliana Mititelu-Tartau"]}],"id":[{"id":"10.13039\/501100006472","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This paper is focused on the in vivo release and biocompatibility evaluation in rats of some novel systems entrapping zinc chloride in lipid vesicles. The particles were prepared by zinc chloride immobilization inside lipid vesicles made using phosphatidylcholine, stabilized with 0.5% chitosan solution, and dialyzed for 10 h to achieve a neutral pH. The submicrometric systems were physico-chemically characterized. White Wistar rats, assigned into four groups of six animals each, were treated orally with a single dose, as follows: Group I (control): deionized water 0.3 mL\/100 g body weight; Group II (Zn): 2 mg\/kg body weight (kbw) zinc chloride; Group III (LV-Zn): 2 mg\/kbw zinc chloride in vesicles; Group IV (LVC-Zn): 2 mg\/kbw zinc chloride in vesicles stabilized with chitosan. Haematological, biochemical, and immune parameters were assessed after 24 h and 7 days, and then liver fragments were collected for histopathological examination. The use of zinc submicrometric particles\u2014especially those stabilized with chitosan\u2014showed a delayed zinc release in rats. No substantial changes to blood parameters, plasma biochemical tests, serum complement activity, or peripheral neutrophils phagocytic capacity were noted; moreover, the tested substances did not induce liver architectural disturbances. The obtained systems provided a delayed release of zinc, and showed good biocompatibility in rats.<\/jats:p>","DOI":"10.3390\/molecules26134101","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T22:02:04Z","timestamp":1625522524000},"page":"4101","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the In Vivo Release and Biocompatibility of Novel Vesicles Containing Zinc in Rats"],"prefix":"10.3390","volume":"26","author":[{"given":"Liliana","family":"Mititelu-Tartau","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8089-1787","authenticated-orcid":false,"given":"Maria","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, University of Medicine and Pharmacy, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Angelica","family":"Pricop","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Physics, \u201cAl. I. Cuza\u201d University, 700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice Rozalina","family":"Buca","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Maria","family":"Pauna","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Anda","family":"Dijmarescu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics-Gynecology, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-3780","authenticated-orcid":false,"given":"Ana-Maria","family":"Pelin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 800010 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana Lacramioara","family":"Pavel","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 800010 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gratiela Eliza","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"ref_1","first-page":"751","article-title":"The protective effects of zinc in experimental gentamicin induced acute renal failure in rats","volume":"67","author":"Teslariu","year":"2016","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/1541-4337.12067","article-title":"Zinc: The Metal of Life","volume":"13","author":"Kaur","year":"2014","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.freeradbiomed.2012.08.568","article-title":"Zinc and the modulation of redox homeostasis","volume":"53","author":"Oteiza","year":"2012","journal-title":"Free Radic. Biol. 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