{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:55:22Z","timestamp":1791921322306,"version":"4.3.4"},"reference-count":38,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001159","name":"Hawaii Community Foundation","doi-asserted-by":"publisher","award":["20CON-102163"],"award-info":[{"award-number":["20CON-102163"]}],"id":[{"id":"10.13039\/100001159","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hawaii IDeA Network for Biomedical Research Excellence IV (INBRE-IV) project","award":["NIGMS Grant 5P20GM103466"],"award-info":[{"award-number":["NIGMS Grant 5P20GM103466"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Aspergillus is one of the most diverse genera, and it is chemically profound and known to produce many biologically active secondary metabolites. In the present study, a new aspochalasin H1 (1), together with nine known compounds (2\u201310), were isolated from a Hawaiian plant-associated endophytic fungus Aspergillus sp. FT1307. The structures were elucidated using nuclear magnetic resonance (NMR) (1H, 1H-1H COSY, HSQC, HMBC, ROESY and 1D NOE), high-resolution electrospray ionization mass spectroscopy (HRESIMS), and comparisons with the reported literature. The absolute configuration of the new compound was established by electronic circular dichroism (ECD) in combination with NMR calculations. The new compound contains an epoxide moiety and an adjacent trans-diol, which has not been reported before in the aspochalasin family. The antibacterial screening of the isolated compounds was carried out against pathogenic bacteria (Staphylococcus aureus, Methicillin-resistant S. aureus and Bacillus subtilis). The antiproliferative activity of compounds 1\u201310 was evaluated against human breast cancer cell lines (MCF-7 and T46D) and ovarian cancer cell lines (A2780).<\/jats:p>","DOI":"10.3390\/molecules26144239","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T21:56:37Z","timestamp":1626126997000},"page":"4239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Aspochalasin H1: A New Cyclic Aspochalasin from Hawaiian Plant-Associated Endophytic Fungus Aspergillus sp. FT1307"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-3435","authenticated-orcid":false,"given":"Mallique","family":"Qader","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai\u2019i at Hilo, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KH Ahammad Uz","family":"Zaman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai\u2019i at Hilo, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenquan","family":"Hu","sequence":"additional","affiliation":[{"name":"Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen 518172, China"},{"name":"School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai\u2019i at Hilo, Hilo, HI 96720, USA"},{"name":"Guangxi Key Laboratory of Chemistry and Chemical Engineering of Forest Products, School of Chemistry for Nationalities, Nanning 530006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai\u2019i at Hilo, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6684-8221","authenticated-orcid":false,"given":"Shugeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai\u2019i at Hilo, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12415","DOI":"10.1021\/acs.chemrev.7b00283","article-title":"Natural products as platforms to overcome antibiotic resistance","volume":"117","author":"Rossiter","year":"2017","journal-title":"Chem. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"PMC-S14459","DOI":"10.4137\/PMC.S14459","article-title":"Antibiotics and bacterial resistance in the 21st century","volume":"6","author":"Fair","year":"2014","journal-title":"Perspect. Med. 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