{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:24:18Z","timestamp":1787887458391,"version":"build-2784847793"},"reference-count":38,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"publisher","award":["PSR2018_DIP_005_COLOMBO_VALENTINA cup: G46C18001430005"],"award-info":[{"award-number":["PSR2018_DIP_005_COLOMBO_VALENTINA cup: G46C18001430005"]}],"id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.<\/jats:p>","DOI":"10.3390\/molecules26164869","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T21:48:12Z","timestamp":1628718492000},"page":"4869","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Solvatomorphism of Moxidectin"],"prefix":"10.3390","volume":"26","author":[{"given":"Toni","family":"Grell","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica, Universit\u00e0 degli Studi di Milano, Via Golgi 19, I-20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8148-1904","authenticated-orcid":false,"given":"Mauro","family":"Barbero","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 del Piemonte Orientale A. Avogadro, Largo Donegani 2\/3, I-28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Pattarino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 del Piemonte Orientale A. Avogadro, Largo Donegani 2\/3, I-28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-0347","authenticated-orcid":false,"given":"Giovanni Battista","family":"Giovenzana","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 del Piemonte Orientale A. Avogadro, Largo Donegani 2\/3, I-28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Colombo","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica, Universit\u00e0 degli Studi di Milano, Via Golgi 19, I-20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Brittain, H.G. (2018). Polymorphism in Pharmaceutical Solids, CRC Press.","DOI":"10.3109\/9781420073225"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bernstein, J. (2007). Polymorphism in Molecular Crystals, Clarendon Press.","DOI":"10.1093\/acprof:oso\/9780199236565.001.0001"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hilfiker, R., and von Raumer, M. (2018). Polymorphism in the Pharmaceutical Industry. 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