{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:19:36Z","timestamp":1789996776717,"version":"4.0.1"},"reference-count":38,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministery of Research and Innovation, CNCS-UEFISCDI","award":["PN-III-P4-ID-PCCF-2016-0050"],"award-info":[{"award-number":["PN-III-P4-ID-PCCF-2016-0050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios of N-acetyl-l-cysteine (NAC) and crosslinked via UV-assisted thiol-ene addition, in order to obtain efficient membranes able to resist bacterial adherence and biofilm formation. These membranes were subjected to in vitro testing for microbial adherence against S. pneumoniae using standardized tests. WISTAR rats were implanted for 4 weeks with crosslinked siloxane samples without and with NAC. A set of physical characterization methods was employed to assess the chemical structure and morphological aspects of the new synthetized materials before and after contact with the microbiological medium.<\/jats:p>","DOI":"10.3390\/molecules26164892","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:54:41Z","timestamp":1628765681000},"page":"4892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antibacterial Polysiloxane Polymers and Coatings for Cochlear Implants"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-7507","authenticated-orcid":false,"given":"Vlad","family":"Cozma","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine, \u201cGrigore T. 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Pol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s00405-011-1818-1","article-title":"Postoperative Complications in Cochlear Implants: A Retrospective Analysis of 438 Consecutive Cases","volume":"269","author":"Ciorba","year":"2012","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_4","unstructured":"(2021, July 21). Infectious Complications in Pediatric Cochlear Implants-Hopfenspirger-2007-The Laryngoscope-Wiley Online Library. Available online: https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1097\/MLG.0b013e3180de4d35."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijporl.2017.02.026","article-title":"Infectious Complications of Pediatric Cochlear Implants Are Highly Influenced by Otitis Media","volume":"97","author":"Vila","year":"2017","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1179\/cim.2004.5.4.160","article-title":"Explantation and Reimplantation of Cochlear Implants","volume":"5","author":"Ray","year":"2004","journal-title":"Cochlear Implant. Int."},{"key":"ref_7","unstructured":"(2021, July 21). Evolving Strategies to Prevent Implant-Associated Infections: JAAOS-Journal of the American Academy of Orthopaedic Surgeons. Available online: https:\/\/journals.lww.com\/jaaos\/fulltext\/2012\/07000\/evolving_strategies_to_prevent_implant_associated.9.aspx."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/AAC.00741-10","article-title":"Vancomycin Bonded to Bone Grafts Prevents Bacterial Colonization","volume":"55","author":"Ketonis","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3389\/fbioe.2020.603072","article-title":"Surface Modification Techniques of Titanium and Its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review","volume":"8","author":"Xue","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1039\/b702079a","article-title":"Permanently Microbicidal Materials Coatings","volume":"17","author":"Klibanov","year":"2007","journal-title":"J. Mater. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11998-009-9197-x","article-title":"Antimicrobial Activity of Polysiloxane Coatings Containing Quaternary Ammonium-Functionalized Polyhedral Oligomeric. Silsesquioxane","volume":"7","author":"Majumdar","year":"2010","journal-title":"J. Coat. Technol. Res."},{"key":"ref_12","first-page":"Doc10","article-title":"Biomaterials in Cochlear Implants","volume":"8","author":"Lenarz","year":"2011","journal-title":"GMS Curr. Top. Otorhinolaryngol. Head Neck Surg."},{"key":"ref_13","unstructured":"Herberhold, C. Biokompatibilit\u00e4t der Cochlear-Implants. Proceedings of the Teil I: Referate."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/jbm.b.31042","article-title":"The Effect of the Environment on the Mechanical Properties of Medical Grade Silicones","volume":"86B","author":"Leslie","year":"2008","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Nowacka, M., Ryga\u0142a, A., Kr\u0119giel, D., and Kowalewska, A. (2021). New Antiadhesive Hydrophobic Polysiloxanes. Molecules, 26.","DOI":"10.3390\/molecules26040814"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.colsurfb.2018.09.017","article-title":"Poly(Silsesquioxanes) and Poly(Siloxanes) Grafted with N-Acetylcysteine for Eradicating Mature Bacterial Biofilms in Water Environment","volume":"172","author":"Nowacka","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kregiel, D., Rygala, A., Kolesinska, B., Nowacka, M., Herc, A.S., and Kowalewska, A. (2019). Antimicrobial and Antibiofilm N-Acetyl-L-Cysteine Grafted Siloxane Polymers with Potential for Use in Water Systems. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20082011"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1128\/AEM.69.8.4814-4822.2003","article-title":"N-Acetyl-l-Cysteine Affects Growth, Extracellular Polysaccharide Production, and Bacterial Biofilm Formation on Solid Surfaces","volume":"69","author":"Olofsson","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/jobm.201700087","article-title":"Silver Nanoparticles: Antimicrobial Activity, Cytotoxicity, and Synergism with N-Acetyl Cysteine","volume":"57","author":"Hamed","year":"2017","journal-title":"J. Basic Microbiol."},{"key":"ref_20","unstructured":"Opris, D.M., D\u00fcnki, S., Racles, C., Bele, A., and Cazacu, M. (2015). High Permittivity Polymers Based on Functionalized Silicones. (No. WO2015135086), Patent."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1039\/C3TC32382J","article-title":"Preparation and Characterization of Luminescent Silicone Elastomer by Thiol\u2013Ene \u201cClick\u201d Chemistry","volume":"2","author":"Zuo","year":"2014","journal-title":"J. Mater. Chem. C"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Balan, G.G., Rosca, I., Ursu, E.-L., Fifere, A., Varganici, C.-D., Doroftei, F., Turin-Moleavin, I.-A., Sandru, V., Constantinescu, G., and Timofte, D. (2019). Duodenoscope-Associated Infections beyond the Elevator Channel: Alternative Causes for Difficult Reprocessing. Molecules, 24.","DOI":"10.3390\/molecules24122343"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1039\/c3ce40506k","article-title":"Flexible Linkers and Dinuclear Metallic Nodes Build up an Original Metal\u2013Organic Framework","volume":"15","author":"Vlad","year":"2013","journal-title":"CrystEngComm"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jclepro.2017.12.237","article-title":"Ecofriendly Wet\u2013White Leather vs. Conventional Tanned Wet\u2013Blue Leather. A Photochemical Approach","volume":"177","author":"Rosu","year":"2018","journal-title":"J. Clean. Prod."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s10973-012-2532-y","article-title":"Studies on New Hybrid Materials Prepared by Both Diels\u2013Alder and Michael Addition Reactions","volume":"111","author":"Varganici","year":"2013","journal-title":"J. Anal. Calorim."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0141-3910(01)00261-0","article-title":"Kinetic Aspects of the Thermal Degradation of Poly(Dimethyl Siloxane) and Poly(Dimethyl Diphenyl Siloxane)","volume":"76","author":"Deshpande","year":"2002","journal-title":"Polym. Degrad. Stab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1097\/00006534-200205000-00024","article-title":"In Vivo Aging Characteristics of Silicone Gel Breast Implants Compared to Lot-Matched Controls","volume":"109","author":"Brandon","year":"2002","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_28","first-page":"e369","article-title":"In Vitro Degradation of Polydimethylsiloxanes in Breast Implant Applications","volume":"15","author":"Martins","year":"2017","journal-title":"J. Appl. Biomater. Funct. Mater."},{"key":"ref_29","unstructured":"(2021, July 22). Comparison of Contact Angle Hysteresis of Different Probe Liquids on the Same Solid Surface | SpringerLink. Available online: https:\/\/link.springer.com\/article\/10.1007\/s00396-012-2777-9."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"123480","DOI":"10.1016\/j.polymer.2021.123480","article-title":"Elastic Composites with PDMS Matrix and Polysulfone-Supported Silver Nanoparticles as Filler","volume":"217","author":"Racles","year":"2021","journal-title":"Polymer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0021-9797(82)90176-X","article-title":"On Adhesion of Biological Substances to Low Energy Solid Surfaces","volume":"88","author":"Schrader","year":"1982","journal-title":"J. Colloid Interface Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kanematsu, H., Oizumi, A., Sato, T., Kamijo, T., Honma, S., Barry, D.M., Hirai, N., Ogawa, A., Kogo, T., and Kuroda, D. (2018). Biofilm Formation of a Polymer Brush Coating with Ionic Liquids Compared to a Polymer Brush Coating with a Non-Ionic Liquid. Coatings, 8.","DOI":"10.3390\/coatings8110398"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sanchez, C.J., Kumar, N., Lizcano, A., Shivshankar, P., Dunning Hotopp, J.C., Jorgensen, J.H., Tettelin, H., and Orihuela, C.J. (2011). Streptococcus Pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028738"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF02941710","article-title":"Studies on Nutrient Requirements and Cost-Effective Supplements for Ethanol Production by RecombinantE. Coli","volume":"57","author":"Lawford","year":"1996","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/10601329608010854","article-title":"Heterogeneous Catalyzed Copolymerization of Octamethylcyclotetrasiloxane with 1,3,5,7-Tetravinyl-1,3,5,7-Tetramethylcyclo-Tetrasiloxane","volume":"33","author":"Cazacu","year":"1996","journal-title":"J. Macromol. Sci. Part A"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/03602559608000587","article-title":"Cationic Heterogeneous Copolymerization of Octamethylcyclotetrasiloxane with 1,3,5,7-Tetramethyl-1,3,5,7-Tetravinylcyclotetra-Siloxane: Optimization of Reaction Conditions","volume":"35","author":"Cazacu","year":"1996","journal-title":"Polym. Plast. Technol. Eng."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1080\/10601329508013703","article-title":"Functional Polysiloxanes. 3. Reaction of 1,3-Bis(3-Glycidoxypropyl)-1,1,3,3-Tetramethyldisiloxane with Amino Compounds","volume":"32","author":"Harabagiu","year":"1995","journal-title":"J. Macromol. Sci. Part A"},{"key":"ref_38","unstructured":"(2021, July 22). XLSTAT | Statistical Software for Excel. Available online: https:\/\/www.xlstat.com."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/16\/4892\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:44:57Z","timestamp":1760165097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/16\/4892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":38,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["molecules26164892"],"URL":"https:\/\/doi.org\/10.3390\/molecules26164892","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,12]]}}}