{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:39:09Z","timestamp":1791920349326,"version":"4.3.4"},"reference-count":141,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Curcuma longa is very well-known medicinal plant not only in the Asian hemisphere but also known across the globe for its therapeutic and medicinal benefits. The active moiety of Curcuma longa is curcumin and has gained importance in various treatments of various disorders such as antibacterial, antiprotozoal, cancer, obesity, diabetics and wound healing applications. Several techniques had been exploited as reported by researchers for increasing the therapeutic potential and its pharmacological activity. Here, the dictum is the new room for the development of physicochemical, as well as biological, studies for the efficacy in target specificity. Here, we discussed nanoformulation techniques, which lend support to upgrade the characters to the curcumin such as enhancing bioavailability, increasing solubility, modifying metabolisms, and target specificity, prolonged circulation, enhanced permeation. Our manuscript tried to seek the attention of the researcher by framing some solutions of some existing troubleshoots of this bioactive component for enhanced applications and making the formulations feasible at an industrial production scale. This manuscript focuses on recent inventions as well, which can further be implemented at the community level.<\/jats:p>","DOI":"10.3390\/molecules26164998","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T10:54:35Z","timestamp":1629284075000},"page":"4998","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-7603","authenticated-orcid":false,"given":"Hitesh","family":"Chopra","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Protity Shuvra","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Food Science & Nutrition Management, J.D. Birla Institute, Kolkata 700020, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashrita","family":"Das","sequence":"additional","affiliation":[{"name":"School of Community Science & Technology, IIEST Shibpur, Howrah 711103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanima","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-4419","authenticated-orcid":false,"given":"Muddaser","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Botany, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-4209","authenticated-orcid":false,"given":"Sidra","family":"Mubin","sequence":"additional","affiliation":[{"name":"Department of Botany, Hazara University Mansehra, Mansehra 21310, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samka Peregrine","family":"Maishu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Bamenda, Bamenda P.O. Box 39, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokeya","family":"Akter","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jagannath University, Sadarghat, Dhaka 1100, Bangladesh"},{"name":"Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-5693","authenticated-orcid":false,"given":"Md. Habibur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7874-6521","authenticated-orcid":false,"given":"Chenmala","family":"Karthika","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, JSS Academy of Higher Education & Research, Ooty 643001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waheed","family":"Murad","sequence":"additional","affiliation":[{"name":"Department of Botany, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4662-6706","authenticated-orcid":false,"given":"Naeem","family":"Qusty","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah 80200, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa","family":"Qusti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Sciences, University of Ha\u2019il, Ha\u2019il 2440, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-5040","authenticated-orcid":false,"given":"Eida M.","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories, Faculty of Applied Medical Sciences, Umma Al-Qura University, Mecca P.O. Box 715, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-425X","authenticated-orcid":false,"given":"Gaber El-Saber","family":"Batiha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-9159","authenticated-orcid":false,"given":"Farag M. A.","family":"Altalbawy","sequence":"additional","affiliation":[{"name":"National institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, Egypt"},{"name":"Department of Biology, University College of Duba, Tabuk University, Duba 71911, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona I. 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