{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:30:37Z","timestamp":1792071037949,"version":"4.4.0"},"reference-count":242,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2019-108580RA-I00"],"award-info":[{"award-number":["PID2019-108580RA-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RYC2018-024564-I"],"award-info":[{"award-number":["RYC2018-024564-I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the most common age-related neurodegenerative disorder that heavily burdens healthcare systems worldwide. There is a significant requirement to understand the still unknown molecular mechanisms underlying AD. Current evidence shows that two of the major features of AD are transcriptome dysregulation and altered function of RNA binding proteins (RBPs), both of which lead to changes in the expression of different RNA species, including microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and messenger RNAs (mRNAs). In this review, we will conduct a comprehensive overview of how RNA dynamics are altered in AD and how this leads to the differential expression of both short and long RNA species. We will describe how RBP expression and function are altered in AD and how this impacts the expression of different RNA species. Furthermore, we will also show how changes in the abundance of specific RNA species are linked to the pathology of AD.<\/jats:p>","DOI":"10.3390\/molecules26175113","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T04:43:43Z","timestamp":1629780223000},"page":"5113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["RNA Dynamics in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Agnieszka","family":"Rybak-Wolf","sequence":"first","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine (MDC), Berlin Institute for Medical Systems Biology (BIMSB), 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireya","family":"Plass","sequence":"additional","affiliation":[{"name":"Gene Regulation of Cell Identity, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L\u2019Hospitalet del Llobregat, 08908 Barcelona, Spain"},{"name":"Program for Advancing Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L\u2019Hospitalet del Llobregat, 08908 Barcelona, Spain"},{"name":"Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1212\/WNL.54.11.2072","article-title":"Age-specific incidence rates of Alzheimer\u2019s disease","volume":"54","author":"Kawas","year":"2000","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","article-title":"Early-Onset Autosomal Dominant Alzheimer Disease: Prevalence, Genetic Heterogeneity, and Mutation Spectrum","volume":"65","author":"Campion","year":"1999","journal-title":"Am. 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