{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:35:55Z","timestamp":1769758555645,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073608"],"award-info":[{"award-number":["82073608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A novel diatomite-supported zeolitic imidazolate framework-8 sorbent (ZIF-8@Dt-COOH) was in situ fabricated and developed for solid-phase extraction of three benzodiazepines (triazolam, midazolam and diazepam) in urine followed by high-performance liquid chromatography. ZIF-8@Dt-COOH was easily prepared by coating ZIF-8 on the surface of Dt-COOH and characterized by Fourier transform infrared spectra, X-ray powder diffractometry and scanning electron microscopy. Compared with bare Dt-COOH, the extraction efficiency of ZIF-8@Dt-COOH for the target was significantly increased from 20.1\u201339.0% to 100%. Main extraction parameters, including ionic strength and pH of solution, loading volume, washing solution, elution solvent and elution volume, were optimized in detail. Under optimum conditions, the developed method gave linearity of three BZDs in 2\u2013500 ng\/mL (r \u2265 0.9995). Limits of detection (S\/N = 3), and limits of quantification (S\/N = 10) were 0.3\u20130.4 ng\/mL and 1.0\u20131.3 ng\/mL, respectively. In addition, the average recoveries at three spiked levels (5, 10 and 20 ng\/mL) varied from 80.0% to 98.7%, with the intra-day and inter-day precisions of 1.4\u20135.2% and 1.5\u20138.2%, respectively. The proposed method provided an effective purification performance and gave the enrichment factors of 24.0\u201329.6. The proposed method was successfully employed for the accurate and sensitive determination of benzodiazepines in urine.<\/jats:p>","DOI":"10.3390\/molecules26175209","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T04:07:28Z","timestamp":1630382848000},"page":"5209","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Facile Fabrication of Diatomite-Supported ZIF-8 Composite for Solid-Phase Extraction of Benzodiazepines in Urine Samples Prior to High-Performance Liquid Chromatography"],"prefix":"10.3390","volume":"26","author":[{"given":"Li","family":"Du","sequence":"first","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaonan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuesheng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"},{"name":"Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Caofeidian, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-6321","authenticated-orcid":false,"given":"Manman","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology, Tangshan 063210, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Silva, A.V.D., Meneghetti, S.M.P., and Meneghetti, M.R. 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