{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:12:54Z","timestamp":1788973974465,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2021BEG03103"],"award-info":[{"award-number":["2021BEG03103"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013494","name":"West Light Foundation of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XAB2020YW15"],"award-info":[{"award-number":["XAB2020YW15"]}],"id":[{"id":"10.13039\/501100013494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2019423126"],"award-info":[{"award-number":["H2019423126"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation of Hebei Province Education Department","award":["QN2021107"],"award-info":[{"award-number":["QN2021107"]}]},{"name":"Research Foundation of Hebei Provincial Administration of Traditional Chinese Medicine","award":["2019086"],"award-info":[{"award-number":["2019086"]}]},{"name":"Research Foundation of Hebei Provincial Administration of Traditional Chinese Medicine","award":["2019079"],"award-info":[{"award-number":["2019079"]}]},{"name":"Innovation Team of Hebei Province Modern Agricultural Industry Technology System","award":["HBCT2018060205"],"award-info":[{"award-number":["HBCT2018060205"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The investigation of the constituents of the rhizomes of Dioscorea collettii afforded one new dihydroisocoumarin, named (\u2212)-montroumarin (1a), along with five known compounds\u2014montroumarin (1b), 1,1\u2032-oxybis(2,4-di-tert-butylbenzene) (2), (3R)-3\u2032-O-methylviolanone (3a), (3S)-3\u2032-O-methylviolanone (3b), and (RS)-sativanone (4). Their structures were elucidated using extensive spectroscopic methods. To the best of our knowledge, compound 1a is a new enantiomer of compound 1b. The NMR data of compound 2 had been reported but its structure was erroneous. The structure of compound 2 was revised on the basis of a reinterpretation of its NMR data (1D and 2D) and the assignment of the 1H and 13C NMR data was given rightly for the first time. Compounds 3a\u20134, three dihydroisoflavones, were reported from the Dioscoreaceae family for the first time. The cytotoxic activities of all the compounds were tested against the NCI-H460 cell line. Two dihydroisocoumarins, compounds 1a and 1b, displayed moderate cytotoxic activities, while the other compounds showed no cytotoxicity.<\/jats:p>","DOI":"10.3390\/molecules26175381","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:18:26Z","timestamp":1630934306000},"page":"5381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dihydroisocoumarins and Dihydroisoflavones from the Rhizomes of Dioscorea collettii with Cytotoxic Activity and Structural Revision of 2,2\u2032-Oxybis(1,4-di-tert-butylbenzene)"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1610-2936","authenticated-orcid":false,"given":"Songsong","family":"Jing","sequence":"first","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang 050200, China"},{"name":"Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2571-5542","authenticated-orcid":false,"given":"Long","family":"Guo","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Hebei University of Chinese Medicine, Shijiazhuang 050200, China"},{"name":"Hebei Chemical & Pharmaceutical College, Shijiazhuang 050200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biopha.2017.06.022","article-title":"Saponins extracted from Dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats","volume":"93","author":"Zhu","year":"2017","journal-title":"Biomed. 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