{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:24:31Z","timestamp":1790169871722,"version":"4.1.0"},"reference-count":53,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003768","name":"Universit\u00e9 de Strasbourg","doi-asserted-by":"publisher","award":["IDEX 2019"],"award-info":[{"award-number":["IDEX 2019"]}],"id":[{"id":"10.13039\/501100003768","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003768","name":"Universit\u00e9 de Strasbourg","doi-asserted-by":"publisher","award":["ITI InnoVec 2021"],"award-info":[{"award-number":["ITI InnoVec 2021"]}],"id":[{"id":"10.13039\/501100003768","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["#2021"],"award-info":[{"award-number":["#2021"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["#2021"],"award-info":[{"award-number":["#2021"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["#2018"],"award-info":[{"award-number":["#2018"]}],"id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["COST 2018"],"award-info":[{"award-number":["COST 2018"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ECOS","award":["#2018"],"award-info":[{"award-number":["#2018"]}]},{"name":"ITMO Cancer","award":["#2020"],"award-info":[{"award-number":["#2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Metal complexes have been used to treat cancer since the discovery of cisplatin and its interaction with DNA in the 1960\u2019s. Facing the resistance mechanisms against platinum salts and their side effects, safer therapeutic approaches have been sought through other metals, including ruthenium. In the early 2000s, Michel Pfeffer and his collaborators started to investigate the biological activity of organo-ruthenium\/osmium complexes, demonstrating their ability to interfere with the activity of purified redox enzymes. Then, they discovered that these organo-ruthenium\/osmium complexes could act independently of DNA damage and bypass the requirement for the tumor suppressor gene TP53 to induce the endoplasmic reticulum (ER) stress pathway, which is an original cell death pathway. They showed that other types of ruthenium complexes\u2014as well complexes with other metals (osmium, iron, platinum)\u2014can induce this pathway as well. They also demonstrated that ruthenium complexes accumulate in the ER after entering the cell using passive and active mechanisms. These particular physico-chemical properties of the organometallic complexes designed by Dr. Pfeffer contribute to their ability to reduce tumor growth and angiogenesis. Taken together, the pioneering work of Dr. Michel Pfeffer over his career provides us with a legacy that we have yet to fully embrace.<\/jats:p>","DOI":"10.3390\/molecules26175386","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:18:26Z","timestamp":1630934306000},"page":"5386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-3851","authenticated-orcid":false,"given":"Christian","family":"Gaiddon","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Strasbourg-Inserm, UMR_S 1113 IRFAC, 67200 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-8773","authenticated-orcid":false,"given":"Isabelle","family":"Gross","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg-Inserm, UMR_S 1113 IRFAC, 67200 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Gastro-Oncology, 7th Hospital, Shanghai 200137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Sidhoum","sequence":"additional","affiliation":[{"name":"Domain Therapeutics, 67400 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-0789","authenticated-orcid":false,"given":"Georg","family":"Mellitzer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg-Inserm, UMR_S 1113 IRFAC, 67200 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Romain","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg-Inserm, UMR_S 1113 IRFAC, 67200 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Batiste","family":"Delhorme","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg-Inserm, UMR_S 1113 IRFAC, 67200 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00efna","family":"Venkatasamy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg-Inserm, UMR_S 1113 IRFAC, 67200 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain C.","family":"Jung","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg-Inserm, UMR_S 1113 IRFAC, 67200 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"CNRS UMR 7177, Institute of Chemistry, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4251\/wjgo.v11.i10.804","article-title":"Precision medicine in gastric cancer","volume":"11","author":"Bonelli","year":"2019","journal-title":"World J. 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