{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:33:16Z","timestamp":1782905596404,"version":"3.54.5"},"reference-count":62,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Products of natural origin remain important in the discovery of new bioactive molecules and are less damaging to the environment. Benzaldehyde is a product of the metabolism of plants, and similarly to oxygenated terpenes, it can have antibacterial activity against Staphylococcus aureus and toxic action against Drosophila melanogaster; we aimed to verify these activities. The broth microdilution tests determined the minimum inhibitory concentration (MIC) of benzaldehyde alone and in association with antibiotics and ethidium bromide (EtBr). Toxicity against Drosophila melanogaster was determined by fumigation tests that measured lethality and damage to the locomotor system. The results indicated that there was an association of norfloxacin and ciprofloxacin with benzaldehyde, from 64 \u03bcg\/mL to 32 \u03bcg\/mL of ciprofloxacin in the strain K6028 and from 256 \u03bcg\/mL to 128 \u03bcg\/mL of norfloxacin in the strain 1199B; however, the associations were not able to interfere with the functioning of the tested efflux pumps. In addition, benzaldehyde had a toxic effect on flies. Thus, the results proved the ability of benzaldehyde to modulate quinolone antibiotics and its toxic effects on fruit flies, thus enabling further studies in this area.<\/jats:p>","DOI":"10.3390\/molecules26185570","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T23:32:23Z","timestamp":1631575943000},"page":"5570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of Benzaldehyde as an Antibiotic Modulator and Its Toxic Effect against Drosophila melanogaster"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-3215","authenticated-orcid":false,"given":"Luiz Jardelino de Lacerda","family":"Neto","sequence":"first","affiliation":[{"name":"Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri, Crato 63105-000, CE, Brazil"},{"name":"Graduate Program in Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreza Guedes Barbosa","family":"Ramos","sequence":"additional","affiliation":[{"name":"Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri, Crato 63105-000, CE, Brazil"},{"name":"Graduate Program in Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Sampaio de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Graduate Program in Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"},{"name":"Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri (URCA), Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Rodrigues dos Santos","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Graduate Program in Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"},{"name":"Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri (URCA), Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1rcio Luiz","family":"de Sousa J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri, Crato 63105-000, CE, Brazil"},{"name":"Graduate Program in Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolghasem","family":"Siyadatpanah","sequence":"additional","affiliation":[{"name":"Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717434765, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Nejat","sequence":"additional","affiliation":[{"name":"Master of Internal Surgery Nursing, Birjand University of Medical Sciences, Birjand 9717434765, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-7788","authenticated-orcid":false,"given":"Polrat","family":"Wilairatana","sequence":"additional","affiliation":[{"name":"Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri (URCA), Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Assis Bezerra","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1002\/jsfa.4021","article-title":"Seasonal variation in content, chemical composition and antimicrobial and cytotoxic activities of essential oils from four Mentha species","volume":"90","author":"Hussain","year":"2010","journal-title":"J. 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