{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:10:31Z","timestamp":1774066231136,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mexican Social Security Institute","award":["FIS\/IMSS\/PROT\/G11\/956"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G11\/956"]}]},{"DOI":"10.13039\/501100020042","name":"Universidad de Monterrey","doi-asserted-by":"publisher","award":["UIN-18596"],"award-info":[{"award-number":["UIN-18596"]}],"id":[{"id":"10.13039\/501100020042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020042","name":"Universidad de Monterrey","doi-asserted-by":"publisher","award":["UIN-19601"],"award-info":[{"award-number":["UIN-19601"]}],"id":[{"id":"10.13039\/501100020042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Arsenic is considered a worldwide pollutant that can be present in drinking water. Arsenic exposure is associated with various diseases, including cancer. Antioxidants as selenite and \u03b1-tocopherol-succinate have been shown to modulate arsenic toxic effects. Since changes in STAT3 and PSMD10 gene expression have been associated with carcinogenesis, the aim of this study was to evaluate the effect of arsenic exposure and co-treatments with selenite or \u03b1-tocopherol-succinate on the expression of these genes, in the livers of chronically exposed Syrian golden hamsters. Animals were divided into six groups: (i) control, (ii) chronically treated with 100 ppm arsenic, (iii) treated with 6 ppm \u03b1-tocopherol-succinate (\u03b1-TOS), (iv) treated with 8.5 ppm selenite, (v) treated with arsenic + \u03b1-TOS, and (vi) treated with arsenic + selenite. Urine samples and livers were collected after 20 weeks of continuous exposure. The urine samples were analyzed for arsenic species by atomic absorption spectrophotometry, and real-time RT-qPCR analysis was performed for gene expression evaluation. A reduction in STAT3 expression was observed in the selenite-treated group. No differences in PSMD10 expression were found among groups. Histopathological analysis revealed hepatic lymphocytosis in selenite-treated animals. As a conclusion, long-term exposure to arsenic does not significantly alter the expression of STAT3 and PSMD10 oncogenes in the livers of hamsters; however, selenite down-regulates STAT3 expression and provokes lymphocytosis.<\/jats:p>","DOI":"10.3390\/molecules26185614","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:13:47Z","timestamp":1631924027000},"page":"5614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Selenite Downregulates STAT3 Expression and Provokes Lymphocytosis in the Liver of Chronically Exposed Syrian Golden Hamsters"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-6574","authenticated-orcid":false,"given":"Mar\u00eda","family":"Camacho-Moll","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Noreste, Departamento de Biolog\u00eda Molecular, Instituto Mexicano del Seguro Social, Monterrey 64720, Nuevo Le\u00f3n, Mexico"},{"name":"Departamento de Ciencias B\u00e1sicas, Vicerrector\u00eda de Ciencias de la Salud, Universidad de Monterrey, San Pedro Garza Garc\u00eda 66238, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Sampayo-Reyes","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, San Nicol\u00e1s de los Garza 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-0004","authenticated-orcid":false,"given":"Fabiola","family":"Castorena-Torres","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Tecnologico de Monterrey, Monterrey 64710, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Lozano-Garza","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Noreste, Departamento de Biolog\u00eda Molecular, Instituto Mexicano del Seguro Social, Monterrey 64720, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Alarc\u00f3n-Galv\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Vicerrector\u00eda de Ciencias de la Salud, Universidad de Monterrey, San Pedro Garza Garc\u00eda 66238, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7891-357X","authenticated-orcid":false,"given":"Ricard","family":"Marcos","sequence":"additional","affiliation":[{"name":"Grup de Mutag\u00e8nesi, Departament de Gen\u00e8tica i de Microbiologia, Facultat de Bioci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1398-7898","authenticated-orcid":false,"given":"Juan","family":"Alcocer-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, San Nicol\u00e1s de los Garza 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyes","family":"Tamez-Guerra","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, San Nicol\u00e1s de los Garza 66455, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-2969","authenticated-orcid":false,"given":"Mario","family":"Berm\u00fadez de Le\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Noreste, Departamento de Biolog\u00eda Molecular, Instituto Mexicano del Seguro Social, Monterrey 64720, Nuevo Le\u00f3n, Mexico"},{"name":"Departamento de Ciencias B\u00e1sicas, Vicerrector\u00eda de Ciencias de la Salud, Universidad de Monterrey, San Pedro Garza Garc\u00eda 66238, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"ref_1","unstructured":"Cullen, W.R. 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