{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:57:06Z","timestamp":1773316626939,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773692"],"award-info":[{"award-number":["81773692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20180101187JC"],"award-info":[{"award-number":["20180101187JC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Poloxamer188 (PL188), as one of the most commonly used pharmaceutical excipients, has unique physicochemical properties and good biocompatibility, and so is playing an increasingly extensive role in the field of medicine. Currently, there are few studies on the tissue distribution of PL188 in vivo. In this study, the LC-MS method based on MSALL technique of quadrupole time of flight mass spectrometry for absolute quantitative analysis of poloxamer 188 in biological substrates was established for the first time. The tissue distribution of poloxamer188 in SD rats were studied using the established quantitative analysis method. To explore the distribution of PL188 in organs and tissues, PL188 was administered via rat tail vein at a dose of 5 mg\/kg. Eight kinds of tissues including heart, liver, spleen, lung, kidney, stomach, muscle and brain of rats were collected at 0.25 h, 1 h and 4 h after administration. Tissue distributions showed the highest level was observed in kidney, then in stomach, which indicated PL188 mainly bioaccumulated in the kidney. This study can provide references for the further study of PL188.<\/jats:p>","DOI":"10.3390\/molecules26185644","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:13:47Z","timestamp":1631924027000},"page":"5644","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tissue Distribution Study of Poloxamer188 in Rats by Ultra-High-Performance Liquid Chromatography Quadrupole Time of Flight\/Mass Spectrometry with MSALL-Based Approach"],"prefix":"10.3390","volume":"26","author":[{"given":"Yixuan","family":"Feng","sequence":"first","affiliation":[{"name":"School of Pharmacy, Jilin Medical University, Jilin 132013, China"},{"name":"School of Life Sciences, Jilin University, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-2344","authenticated-orcid":false,"given":"Lele","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.2174\/09298673113209990036","article-title":"Pluronic-Based Core\/Shell Nanoparticles for Drug Delivery and Diagnosis","volume":"20","author":"Jung","year":"2013","journal-title":"Curr. 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