{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:13:22Z","timestamp":1776795202431,"version":"3.51.2"},"reference-count":172,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Molecules"],"abstract":"<jats:p>Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy (RT) are the common cancer treatments. In addition to these limitations, the development of adverse effects from chemotherapy and RT reduces the quality of life for cancer patients. Cellular radiosensitivity, or the ability to resist and overcome cell damage caused by ionizing radiation (IR), is directly related to cancer cells\u2019 response to RT. Therefore, radiobiological research is emphasizing chemical compounds \u2019radiosensitization of cancer cells so that they are more reactive in the IR spectrum. Recent years researchers have seen an increase in interest in natural products that have antitumor effects with minimal side effects. Natural products, on the other hand, are easy to recover and therefore less expensive. There have been several scientific studies done based on these compounds that have tested their ability in vitro and in vivo to induce tumor radiosensitization. The role of natural products in RT, as well as their usefulness and potential applications, is the goal of this current review.<\/jats:p>","DOI":"10.3390\/molecules26195997","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T21:23:55Z","timestamp":1633728235000},"page":"5997","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["RETRACTED: Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives"],"prefix":"10.3390","volume":"26","author":[{"given":"Rokeya","family":"Akter","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Jagannath University, Dhaka 1100, Bangladesh"},{"name":"Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-8884","authenticated-orcid":false,"given":"Agnieszka","family":"Najda","sequence":"additional","affiliation":[{"name":"Department of Vegetable and Herbal Crops, University of Life Sciences in Lublin, 50A Do\u015bwiadczalna Street, 20-280 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-5693","authenticated-orcid":false,"given":"Md.","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Republic of Korea"},{"name":"Department of Pharmacy, Southeast University, Banani Street, Dhaka 1213, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-4419","authenticated-orcid":false,"given":"Muddaser","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Botany, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan"},{"name":"Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylwia","family":"Weso\u0142owska","sequence":"additional","affiliation":[{"name":"Institute of Soil Science and Environment Shaping, University of Life Sciences in Lublin, 7 Leszczy\u0144skiego Street, 20-069 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-6540","authenticated-orcid":false,"given":"Syed","family":"Hassan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-4209","authenticated-orcid":false,"given":"Sidra","family":"Mubin","sequence":"additional","affiliation":[{"name":"Department of Botany, Hazara University Mansehra, Mansehra 21310, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-9527","authenticated-orcid":false,"given":"Parveen","family":"Bibi","sequence":"additional","affiliation":[{"name":"Department of Botany, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeeda","family":"Saeeda","sequence":"additional","affiliation":[{"name":"Department of Botany, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111704","DOI":"10.1016\/j.biopha.2021.111704","article-title":"Pharmacotherapy, Multiple strategies with the synergistic approach for addressing colorectal cancer","volume":"140","author":"Karthika","year":"2021","journal-title":"Biomed. 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