{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:00:39Z","timestamp":1787310039113,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010096","name":"Secretariat of Public Education","doi-asserted-by":"publisher","award":["PRODEP PTC-404"],"award-info":[{"award-number":["PRODEP PTC-404"]}],"id":[{"id":"10.13039\/100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004803","name":"Universidad Michoacana de San Nicol\u00e1s de Hidalgo","doi-asserted-by":"publisher","award":["CIC-UMSNH (15794)"],"award-info":[{"award-number":["CIC-UMSNH (15794)"]}],"id":[{"id":"10.13039\/501100004803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A high-order multicomponent reaction involving a six-component reaction to obtain the novel linked 1,5-disubstituted tetrazole-1,2,3-triazole hybrids in low to moderate yield is described. This one-pot reaction is carried out under a cascade process consisting of three sequential reactions: Ugi-azide, bimolecular nucleophilic substitution (SN2), and copper-catalyzed alkyne\u2013azide reaction (CuAAC), with high atom and step-economy due the formation of six new bonds (one C-C, four C-N, and one N-N). Thus, the protocol developed offers operational simplicity, mild reaction conditions, and structural diversity. Finally, to evaluate the antitumoral potential of the synthetized molecules, a proliferation study was performed in the breast cancer (BC) derived cell line MCF-7. The hybrid compounds showed several degrees of cell proliferation inhibition with a remarkable effect in those compounds with cyclohexane and halogens in their structures. These compounds represent potential drug candidates for breast cancer treatment. However, additionally assays are needed to elucidate their complete effect over the cellular hallmarks of cancer.<\/jats:p>","DOI":"10.3390\/molecules26206104","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T21:37:29Z","timestamp":1633901849000},"page":"6104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A One-Pot Six-Component Reaction for the Synthesis of 1,5-Disubstituted Tetrazol-1,2,3-Triazole Hybrids and Their Cytotoxic Activity against the MCF-7 Cell Line"],"prefix":"10.3390","volume":"26","author":[{"given":"Cesia M.","family":"Aguilar-Morales","sequence":"first","affiliation":[{"name":"Laboratorio de Dise\u00f1o Molecular, Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Ciudad Universitaria, Morelia C.P. 58033, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Gustavo","family":"Araujo-Huitrado","sequence":"additional","affiliation":[{"name":"Laboratorio de microRNAs y C\u00e1ncer, Universidad Aut\u00f3noma de Zacatecas, Av. Preparatoria S\/N, Agron\u00f3mica, Campus II, Zacatecas C.P. 98066, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-603X","authenticated-orcid":false,"given":"Yamil\u00e9","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Metabol\u00f3mica y Prote\u00f3mica, CONACyT-Universidad Aut\u00f3noma de Zacatecas, Av. Preparatoria S\/N, Agron\u00f3mica, Campus II, Zacatecas C.P. 98066, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-7160","authenticated-orcid":false,"given":"Claudia","family":"Contreras-Celed\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Dise\u00f1o Molecular, Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Ciudad Universitaria, Morelia C.P. 58033, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0975-5904","authenticated-orcid":false,"given":"Alejandro","family":"Islas-J\u00e1come","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Ciudad de Mexico C.P. 09340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica Judith","family":"Granados-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de microRNAs y C\u00e1ncer, Universidad Aut\u00f3noma de Zacatecas, Av. Preparatoria S\/N, Agron\u00f3mica, Campus II, Zacatecas C.P. 98066, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar R.","family":"Solorio-Alvarado","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Divisi\u00f3n de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Noria Alta S\/N, Guanajuato C.P. 36050, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-7041","authenticated-orcid":false,"given":"Jes\u00fas Adri\u00e1n","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de microRNAs y C\u00e1ncer, Universidad Aut\u00f3noma de Zacatecas, Av. Preparatoria S\/N, Agron\u00f3mica, Campus II, Zacatecas C.P. 98066, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Chac\u00f3n-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Dise\u00f1o Molecular, Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Ciudad Universitaria, Morelia C.P. 58033, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-6316","authenticated-orcid":false,"given":"Carlos J.","family":"Cort\u00e9s-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Dise\u00f1o Molecular, Instituto de Investigaciones Qu\u00edmico-Biol\u00f3gicas, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Ciudad Universitaria, Morelia C.P. 58033, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"44247","DOI":"10.1039\/D0RA09198G","article-title":"Prescribed drugs containing nitrogen heterocycles: An overview","volume":"10","author":"Heravi","year":"2020","journal-title":"RSC Adv."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kerru, N., Gummidi, L., Maddila, S., Gangu, K.K., and Jonnalagadda, S.B. 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