{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:46:59Z","timestamp":1787161619685,"version":"build-2736575974"},"reference-count":72,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agriculture Research Development Agency (Publics) of Thailand","award":["CRP5905021550"],"award-info":[{"award-number":["CRP5905021550"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Iron fortifications are used for the treatment of iron-deficiency anemia; however, iron dosing may cause oxidative damage to the gut lumen. Thai Sinlek rice is abundant in iron and contains phytochemicals. We aimed at evaluating the effect of an iron-rice (IR) hydrolysate drink (100 mL\/serving) on neurological function, red cell indices and iron status in elders. Healthy elderly subjects were divided into three non-anemic groups and one anemic group. The non-anemic groups consumed one WR (2 mg iron\/serving) and two IR drinks (15 and 27 mg iron\/serving) (groups A, B and D, respectively), while the anemic group consumed one IR drink (15 mg iron serving) (group C) every day for 30 days. There were no significant differences in the MMSE Thai 2002 and PHQ9 test scores for members of all groups, while the nutrition scores and body weight values of group D subjects were significantly increased. Hemoglobin (Hb) and mean corpuscular hemoglobin concentrations increased significantly only in group C. Serum iron and transferrin saturation levels tended to increase in group A, while these levels were decreased in members of group C. Serum antioxidant activity levels were increased in all groups, and were highest in group C. Thus, consumption of an IR drink for 15 days functioned to increase Hb and antioxidant capacity levels in anemic elders.<\/jats:p>","DOI":"10.3390\/molecules26206285","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T23:05:47Z","timestamp":1634511947000},"page":"6285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-0639","authenticated-orcid":false,"given":"Peerasak","family":"Lerttrakarnnon","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-6103","authenticated-orcid":false,"given":"Winthana","family":"Kusirisin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-7009","authenticated-orcid":false,"given":"Pimpisid","family":"Koonyosying","sequence":"additional","affiliation":[{"name":"Oxidative Stress Cluster, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Flemming","sequence":"additional","affiliation":[{"name":"Oxidative Stress Cluster, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Department of Earth and Environment, Faculty of Science and Engineering, School of Natural Sciences, University of Manchester, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niramon","family":"Utama-ang","sequence":"additional","affiliation":[{"name":"Cluster of High-Value Products from Thai Rice and Plants for Health, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Department of Product Development Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthat","family":"Fucharoen","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University Salaya Campus, Nakornpathom 71300, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-8781","authenticated-orcid":false,"given":"Somdet","family":"Srichairatanakool","sequence":"additional","affiliation":[{"name":"Oxidative Stress Cluster, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","article-title":"Iron deficiency anaemia","volume":"387","author":"Lopez","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0277-9536(01)00185-X","article-title":"Women\u2019s perceptions of iron deficiency and anemia prevention and control in eight developing countries","volume":"55","author":"Galloway","year":"2002","journal-title":"Soc. Sci. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/nep.12940","article-title":"Intravenous iron and erythropoiesis-stimulating agents in haemodialysis: A systematic review and meta-analysis","volume":"22","author":"Roger","year":"2016","journal-title":"Nephrology (Carlton)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10452","DOI":"10.1021\/acsami.8b18648","article-title":"Fe3O4@ Astragalus polysaccharide core-shell nanoparticles for iron deficiency anemia therapy and magnetic resonance imaging in vivo","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.clnesp.2015.09.003","article-title":"Role of nutrition on anemia in elderly","volume":"11","author":"Bianchi","year":"2016","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1300\/J052v15n04_02","article-title":"Iron nutrition in rural home bound elderly persons","volume":"15","author":"Beard","year":"1996","journal-title":"J. Nutr. Elder."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jtemb.2005.02.008","article-title":"Iron content and bioavailability in rice","volume":"18","author":"Meng","year":"2005","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000077046","article-title":"Impact of feeding high-iron rice on plasma iron, hemoglobin and red blood cell variables of early-weaned piglets","volume":"48","author":"Schaffer","year":"2004","journal-title":"A Pilot Study. Ann. Nutr. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"589835","DOI":"10.3389\/fpls.2020.589835","article-title":"Simultaneous biofortification of rice with zinc, iodine, iron and selenium through foliar treatment of a micronutrient cocktail in five countries","volume":"11","author":"Prom","year":"2020","journal-title":"Front. Plant. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fm.2015.08.005","article-title":"Using physical approaches for the attenuation of lactic acid bacteria in an organic rice beverage","volume":"53","author":"Bevilacqua","year":"2015","journal-title":"Food Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1248\/cpb.c17-00634","article-title":"Development of probiotic formulation for the treatment of iron deficiency anemia","volume":"66","author":"Korcok","year":"2018","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1016\/j.biortech.2007.12.021","article-title":"Value-added subcritical water hydrolysate from rice bran and soybean meal","volume":"99","author":"Watchararuji","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2147\/CIA.S58394","article-title":"Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: A case report and a review of the French National Pharmacovigilance Database","volume":"9","author":"Liabeuf","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fpls.2013.00015","article-title":"The road to micronutrient biofortification of rice: Progress and prospects","volume":"4","author":"Bashir","year":"2013","journal-title":"Front. Plant. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1017\/S0029665118002847","article-title":"Iron biofortification interventions to improve iron status and functional outcomes","volume":"78","author":"Finkelstein","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jsfa.4728","article-title":"Gamma-Oryzanol, tocol and mineral compositions in different grain fractions of giant embryo rice mutants","volume":"92","author":"Jeng","year":"2011","journal-title":"J. Sci. Food Agric."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Min, B., McClung, A., and Chen, M.H. (2014). Effects of hydrothermal processes on antioxidants in brown, purple and red bran whole grain rice (Oryza sativa L.). Food Chem., 159.","DOI":"10.1016\/j.foodchem.2014.02.164"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.3390\/nu5104231","article-title":"Iron, human growth, and the global epidemic of obesity","volume":"5","author":"Sangani","year":"2013","journal-title":"Nutrients"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Deng, Q., Wang, Y., Wang, X., Wang, Q., Yi, Z., Xia, J., Hu, Y., Zhang, Y., Wang, J., and Wang, L. (2021). Effects of dietary iron level on growth performance, hematological status, and intestinal function in growing-finishing pigs. J. Anim. Sci., 99.","DOI":"10.1093\/jas\/skab002"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Banach, W., Nitschke, K., Krajewska, N., Mongiallo, W., Matuszak, O., Muszynski, J., and Skrypnik, D. (2020). The association between excess body mass and disturbances in somatic mineral levels. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197306"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/nyas.12478","article-title":"Proposing nutrients and nutrient levels for rice fortification","volume":"1324","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"eaau0790","DOI":"10.1126\/sciadv.aau0790","article-title":"Effects of dietary iron level on growth performance, hematological status, and intestinal function in growing-finishing pigs","volume":"5","author":"Hackl","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1177\/156482650502600407","article-title":"Development of fortified dried broken rice as a complementary food","volume":"26","author":"Chitpan","year":"2005","journal-title":"Food Nutr. Bull."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1024\/0300-9831.74.6.421","article-title":"The potential role of NaFeEDTA as an iron fortificant","volume":"74","author":"Bothwell","year":"2004","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S585","DOI":"10.1177\/15648265070284S411","article-title":"Iron fortification: Its efficacy and safety in relation to infections","volume":"28","author":"Hurrell","year":"2007","journal-title":"Food Nutr. Bull."},{"key":"ref_26","first-page":"743","article-title":"Bioavailability of iron from oral ferric polymaltose in humans","volume":"44","author":"Nielsen","year":"1994","journal-title":"Arzneimittelforschung"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s11255-016-1309-9","article-title":"Oral vitamin C supplementation reduces erythropoietin requirement in hemodialysis patients with functional iron deficiency","volume":"48","author":"Sultana","year":"2016","journal-title":"Int. Urol. Nephrol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1042\/bj2600903","article-title":"Iron release from haemosiderin and ferritin by therapeutic and physiological chelators","volume":"260","author":"Ward","year":"1989","journal-title":"Biochem. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1023\/A:1012257802703","article-title":"Iron promotes cadmium binding to citrate","volume":"225","author":"Martinez","year":"2001","journal-title":"Mol. Cell Biochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/156482650602700103","article-title":"Fortification of soy sauce using various iron sources: Sensory acceptability and shelf stability","volume":"27","author":"Watanapaisantrakul","year":"2006","journal-title":"Food Nutr. Bull."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1039\/C9FO02424G","article-title":"Consumption of a green tea extract-curcumin drink decreases blood urea nitrogen and redox iron in beta-thalassemia patients","volume":"11","author":"Koonyosying","year":"2020","journal-title":"Food Funct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(20)32594-0","article-title":"Iron deficiency","volume":"397","author":"Pasricha","year":"2021","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3945\/jn.111.149021","article-title":"Multiple micronutrient-fortified rice affects physical performance and plasma vitamin B-12 and homocysteine concentrations of Indian school children","volume":"142","author":"Thankachan","year":"2012","journal-title":"J. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4269\/ajtmh.15-0813","article-title":"Cognitive performance and iron status are negatively associated with hookworm infection in cambodian schoolchildren","volume":"95","author":"Kuong","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"de Gier, B., Campos Ponce, M., Perignon, M., Fiorentino, M., Khov, K., Chamnan, C., de Boer, M.R., Parker, M.E., Burja, K., and Dijkhuizen, M.A. (2016). Micronutrient-fortified rice can increase hookworm infection risk: A cluster randomized trial. PLoS One, 11.","DOI":"10.1371\/journal.pone.0145351"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/09637486.2020.1855126","article-title":"Micronutrient-fortified rice improves haemoglobin, anaemia prevalence and cognitive performance among schoolchildren in Gujarat, India: A case-control study","volume":"72","author":"Mahapatra","year":"2021","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1196\/annals.1331.013","article-title":"Tocotrienol: The natural vitamin E to defend the nervous system?","volume":"1031","author":"Sen","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_38","first-page":"188","article-title":"Rice bran dietary supplementation improves neurological symptoms and loss of Purkinje cells in vitamin E-deficient mice","volume":"59","author":"Takahashi","year":"2016","journal-title":"Yonago Acta Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Um, M.Y., Kim, S., Jin, Y.H., Yoon, M., Yang, H., Lee, J., Jung, J., Urade, Y., Huang, Z.L., and Kwon, S. (2017). A novel neurological function of rice bran: A standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H1 receptors. Mol. Nutr. Food Res., 61.","DOI":"10.1002\/mnfr.201700316"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12937-019-0476-9","article-title":"Iron-related dietary pattern increases the risk of poor cognition","volume":"18","author":"Shi","year":"2019","journal-title":"Nutr. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer\u2019s disease and Parkinson\u2019s disease: Targets for therapeutics","volume":"139","author":"Belaidi","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/nutrit\/nux015","article-title":"Impact of high iron intake on cognition and neurodegeneration in humans and in animal models: A systematic review","volume":"75","author":"Agrawal","year":"2017","journal-title":"Nutr. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Bao, W., Rong, Y., Rong, S., and Liu, L. (2012). Dietary iron intake, body iron stores, and the risk of type 2 diabetes: A systematic review and meta-analysis. BMC Med., 10.","DOI":"10.1186\/1741-7015-10-119"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/aje\/kwn273","article-title":"Dietary iron intake and risk of Parkinson\u2019s disease","volume":"168","author":"Logroscino","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/tropej\/fms021","article-title":"Use of iron-fortified rice reduces anemia in infants","volume":"58","author":"Santos","year":"2012","journal-title":"J. Trop. Pediatr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/ajcn\/84.4.822","article-title":"Extruded rice fortified with micronized ground ferric pyrophosphate reduces iron deficiency in Indian schoolchildren: A double-blind randomized controlled trial","volume":"84","author":"Moretti","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/sj.ejcn.1602930","article-title":"Efficacy and safety of twice-weekly administration of three RDAs of iron and folic acid with and without complement of 14 essential micronutrients at one or two RDAs: A placebo-controlled intervention trial in anemic Cambodian infants 6 to 24 months of age","volume":"63","author":"Schumann","year":"2009","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"S4808","DOI":"10.1182\/blood-2019-129679","article-title":"Optimal use of Thai Sinlek rice (IR) provides the nutraceutical effect on erythropoiesis in rats","volume":"134","author":"Koonyosying","year":"2019","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Moor, M.A., Fraga, M.A., Garfein, R.S., Rashidi, H.H., Alcaraz, J., Kritz-Silverstein, D., Elder, J.P., and Brodine, S.K. (2017). Individual and community factors contributing to anemia among women in rural Baja California, Mexico. PLoS One, 12.","DOI":"10.1371\/journal.pone.0188590"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3389\/fphys.2018.00659","article-title":"Unchanged erythrocyte profile after exposure to cryogenic temperatures in elder marathon runners","volume":"9","author":"Szymura","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Bousounis, P., Bergo, V., and Trompouki, E. (2021). Inflammation, aging and hematopoiesis: A complex relationship. Cells, 10.","DOI":"10.3390\/cells10061386"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1024\/0300-9831.78.2.74","article-title":"Efficacy of iron-fortified rice in reducing anemia among schoolchildren in the Philippines","volume":"78","author":"Capanzana","year":"2008","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/jn\/nxaa035","article-title":"Iron absorption from bouillon fortified with iron-enriched Aspergillus oryzae Is higher than that fortified with ferric pyrophosphate in young women","volume":"150","author":"Bries","year":"2020","journal-title":"J. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.yrtph.2008.03.007","article-title":"28-Day repeated dose oral toxicity of recombinant human apo-lactoferrin or recombinant human lysozyme in rats","volume":"51","author":"Cerven","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1023\/A:1007614613771","article-title":"Intake of flavonoids and risk of dementia","volume":"16","author":"Commenges","year":"2000","journal-title":"Eur. J. Epidemiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12263-008-0091-4","article-title":"The neuroprotective potential of flavonoids: A multiplicity of effects","volume":"3","author":"Vauzour","year":"2008","journal-title":"Genes Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1179\/1476830515Y.0000000005","article-title":"Anthocyanin-rich cherry juice does not improve acute cognitive performance on RAVLT","volume":"19","author":"Caldwell","year":"2015","journal-title":"Nutr. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13668-019-0271-4","article-title":"Diet and inflammation in cognitive ageing and Alzheimer\u2019s disease","volume":"8","author":"McGrattan","year":"2019","journal-title":"Curr. Nutr. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.21873\/anticanres.12734","article-title":"Dewaxed brown rice feed improves fatty liver in obese and diabetic model mice","volume":"38","author":"Inagawa","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1021\/jf904407x","article-title":"Effect of anthocyanin-rich extract from black rice (Oryza sativa L. Japonica) on chronically alcohol-induced liver damage in rats","volume":"58","author":"Hou","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.foodchem.2013.03.086","article-title":"Antioxidant activity of white rice, brown rice and germinated brown rice (in vivo and in vitro) and the effects on lipid peroxidation and liver enzymes in hyperlipidaemic rabbits","volume":"141","author":"Amom","year":"2013","journal-title":"Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1021\/jf0714463","article-title":"Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL\/KsJ-db\/db mice","volume":"55","author":"Jung","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_63","first-page":"96","article-title":"In vitro and in vivo antioxidant activity of ethyl acetate extraction of purple rice","volume":"62","author":"Shen","year":"2016","journal-title":"Cell Mol. Biol. (Noisy-le-grand)"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1007\/s12325-017-0580-1","article-title":"Short-term effects of a combined nutraceutical on lipid level, fatty liver biomarkers, hemodynamic parameters, and estimated cardiovascular disease risk: A double-blind, placebo-controlled randomized clinical trial","volume":"34","author":"Cicero","year":"2017","journal-title":"Adv. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.numecd.2014.12.004","article-title":"High-density lipoprotein oxidation in type 2 diabetic patients and young patients with premature myocardial infarction","volume":"25","author":"Sartore","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_66","first-page":"264","article-title":"Inductively coupled plasma mass spectrometry for trace element analysis in the clinical laboratory","volume":"25","author":"Nuttall","year":"1995","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_67","unstructured":"(2003). Compendium of Methods for Food Analysis\/cDepartment of Medical Sciences and National Bureau of Agriculture Commodity and Food Standards."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Boonvisudhi, T., and Kuladee, S. (2017). Association between internet addiction and depression in Thai medical students at Faculty of Medicine, Ramathibodi Hospital. PLoS One, 12.","DOI":"10.1371\/journal.pone.0174209"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/archneur.59.3.385","article-title":"Endogenous estradiol in elderly individuals: Cognitive and noncognitive associations","volume":"59","author":"Senanarong","year":"2002","journal-title":"Arch. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/ggi.12318","article-title":"Development of the Thai version of Mini-Cog, a brief cognitive screening test","volume":"15","author":"Trongsakul","year":"2014","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12603-012-0013-4","article-title":"Serum ferritin and nutritional status in older adults at eldercare facilities","volume":"16","author":"Vasquez","year":"2012","journal-title":"J. Nutr. Health Aging"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/clinchem\/28.7.1730a","article-title":"Ferrozine assay of serum iron and total iron-binding capacity adapted to the COBAS BIO centrifugal analyzer","volume":"28","author":"Schlosnagle","year":"1982","journal-title":"Clin. 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