{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:27:58Z","timestamp":1760236078018,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the current work, mesoporous magnesium carbonate (MMC) was used to suppress crystallization of the poorly soluble drug celecoxib (CXB). This resulted in both a higher dissolution rate and supersaturation of the substance in vitro as well as an increased transfer of CXB over a Caco-2 cell membrane mimicking the membrane in the small intestine. The CXB flux over the cell membrane showed a linear behavior over the explored time period. These results indicate that MMC may be helpful in increasing the bioavailability and obtaining a continuous release of CXB, and similar substances, in vivo. Neusilin US2 was used as a reference material and showed a more rapid initial release with subsequent crystallization of the incorporated CXB in the release media. The presented results form the foundation of future development of MMC as a potential carrier for poorly soluble drugs.<\/jats:p>","DOI":"10.3390\/molecules26216353","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T23:27:39Z","timestamp":1634858859000},"page":"6353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate"],"prefix":"10.3390","volume":"26","author":[{"given":"Johan","family":"G\u00f3mez de la Torre","sequence":"first","affiliation":[{"name":"Division of Nanotechnology and Functional Materials, Department of Materials Science and Engineering, Uppsala University, P.O. Box 534, SE-751 21 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-2612","authenticated-orcid":false,"given":"Christel","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Drug Delivery, Department of Pharmacy, Uppsala University, P.O. Box 580, SE-751 23 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-1095","authenticated-orcid":false,"given":"Teresa","family":"Zard\u00e1n G\u00f3mez de la Torre","sequence":"additional","affiliation":[{"name":"Division of Nanotechnology and Functional Materials, Department of Materials Science and Engineering, Uppsala University, P.O. 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