{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:56:36Z","timestamp":1775814996937,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, the essential oil (EO) from Laurelia sempervirens was analyzed by GC\/MS and safrole (1) was identified as the major metabolite 1, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side chain, and eight compounds (4 to 12) were obtained by the process. EO and compounds 4\u201312 were subjected to biological assays on 24 strains of the genus Saprolegnia, specifically of the species 12 S.\u00a0parasitica and 12 S.\u00a0australis. EO showed a significant effect against Saprolegnia strains. Compound 6 presents the highest activity against two resistant strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 25 to 100 and 75 to 125 \u00b5g\/mL, respectively. The results show that compound 6 exhibited superior activities compared to the commercial controls bronopol and azoxystrobin used to combat these pathogens.<\/jats:p>","DOI":"10.3390\/molecules26216551","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:22:24Z","timestamp":1635805344000},"page":"6551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemical Analysis and In Vitro Bioactivity of Essential Oil of Laurelia sempervirens and Safrole Derivatives against Oomycete Fish Pathogens"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-7032","authenticated-orcid":false,"given":"Alejandro","family":"Madrid","sequence":"first","affiliation":[{"name":"Laboratorio de Productos Naturales y S\u00edntesis Org\u00e1nica (LPNSO), Departamento de Ciencias y Geograf\u00eda, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valpara\u00edso 2340000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lizeth","family":"Morales","sequence":"additional","affiliation":[{"name":"Laboratorio de Productos Naturales y S\u00edntesis Org\u00e1nica (LPNSO), Departamento de Ciencias y Geograf\u00eda, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valpara\u00edso 2340000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Saffirio","sequence":"additional","affiliation":[{"name":"Laboratorio de Productos Naturales y S\u00edntesis Org\u00e1nica (LPNSO), Departamento de Ciencias y Geograf\u00eda, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valpara\u00edso 2340000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio A.","family":"Cuellar","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia, Escuela de Qu\u00edmica y Farmacia, Universidad de Valpara\u00edso, Av. Gran Breta\u00f1a 1093, Valpara\u00edso 2340000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Werner","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Campus Fernando May, Universidad del B\u00edo-B\u00edo, Avda. Andr\u00e9s Bello 720, Casilla 447, Chill\u00e1n 3780000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basti\u00e1n","family":"Said","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Av. Santa Mar\u00eda 6400, Vitacura, Santiago 7630000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricio","family":"Godoy","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Instituto de Microbiolog\u00eda Cl\u00ednica, Universidad Austral de Chile, Los Laureles s\/n, Isla Teja, Valdivia 5090000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Caro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Austral Biotech, Facultad de Ciencias, Universidad Santo Tom\u00e1s, Avda. Ej\u00e9rcito 146, Santiago 8320000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirna","family":"Melo","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Av. Universidad #330, Curauma, Valpara\u00edso 2340000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4187-951X","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Escuela de Obstetricia y Puericultura, Universidad de Valpara\u00edso, Angamos 655, Re\u00f1aca, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Banfield, M.J., and Kamoun, S. (2013). Hooked and Cooked: A Fish Killer Genome Exposed. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003590"},{"key":"ref_2","unstructured":"Mayer, J., and Donnelly, T.M. (2013). Saprolegniasis. Clinical Veterinary Advisor. 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