{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:51:38Z","timestamp":1776829898009,"version":"3.51.2"},"reference-count":49,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bulgarian National Scientific Fund","award":["project \u041a\u041f-06-\u0414\u041a1\/11"],"award-info":[{"award-number":["project \u041a\u041f-06-\u0414\u041a1\/11"]}]},{"DOI":"10.13039\/501100005992","name":"Ministry of Education and Science","doi-asserted-by":"publisher","award":["\u041a\u041f-06-\u0414\u041a1\/11"],"award-info":[{"award-number":["\u041a\u041f-06-\u0414\u041a1\/11"]}],"id":[{"id":"10.13039\/501100005992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open\/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3.<\/jats:p>","DOI":"10.3390\/molecules26216608","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:22:24Z","timestamp":1635805344000},"page":"6608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8050-0149","authenticated-orcid":false,"given":"Petar","family":"Todorov","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-6214","authenticated-orcid":false,"given":"Stela","family":"Georgieva","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desislava","family":"Staneva","sequence":"additional","affiliation":[{"name":"Department of Textile and Leathers, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petia","family":"Peneva","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-382X","authenticated-orcid":false,"given":"Petar","family":"Grozdanov","sequence":"additional","affiliation":[{"name":"The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanka","family":"Nikolova","sequence":"additional","affiliation":[{"name":"The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-8183","authenticated-orcid":false,"given":"Ivo","family":"Grabchev","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sofia University \u201cSt. Kl. Ohridski\u201d, 1407 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0309-1651(90)90015-Q","article-title":"Potentiation of the antiviral activity of poly r (AU) by xanthene dyes","volume":"14","author":"Jamison","year":"1990","journal-title":"Cell Biol. Int. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1021\/cb700248m","article-title":"Bright ideas for chemical biology","volume":"3","author":"Lavis","year":"2008","journal-title":"ACS Chem. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"112664","DOI":"10.1016\/j.ejmech.2020.112664","article-title":"Rhodamine B-based fluorescent probes for molecular mechanism study of the anti-influenza activity of pentacyclic triterpenes","volume":"205","author":"Li","year":"2020","journal-title":"Eur. J. Med. 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