{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:17:49Z","timestamp":1764857869377,"version":"build-2065373602"},"reference-count":63,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973411"],"award-info":[{"award-number":["81973411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2020-084"],"award-info":[{"award-number":["2020-084"]}]},{"name":"Drug Innovation Major Project","award":["2018ZX09101003001-017"],"award-info":[{"award-number":["2018ZX09101003001-017"]}]},{"name":"Shanxi Province Key Research and Development Project, grant number 201703D 111033","award":["201703D 111033"],"award-info":[{"award-number":["201703D 111033"]}]},{"name":"Project of Shanxi Key Laboratory for Innovative Drugs on Inflammation-based major disease \u201cAnti-inflammatory Mechanism of Baihuadexhuangcao Flavone Baogan Capsule\u201d","award":["SXIDL-2018-05"],"award-info":[{"award-number":["SXIDL-2018-05"]}]},{"name":"Project of Center of Comprehensive Development, Utilization and Innovation of Shanxi Medicine","award":["2017-JYXT-18"],"award-info":[{"award-number":["2017-JYXT-18"]}]},{"name":"Special Project for Construction of First-class Professional (for Yunlan Li) in Shanxi Medical University in 2020","award":["no"],"award-info":[{"award-number":["no"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cyclooxygenases 2 (COX2) is a therapeutic target for many inflammation and oxidative stress associated diseases. A high-throughput technique, biolayer interferometry, was performed to primarily screen the potential COX2 binding activities of twelve newly synthesized double hydroxide-based benzophenone derivatives. Binding confirmation was achieved by molecular docking and multi-spectroscopy studies. Such a combined method provided a comprehensive understanding of binding mechanism and conformational changes. Compounds DB2, SC2 and YB2 showed effective COX2 binding activity and underlined the benefits of three phenolic hydroxyl groups adjacent to each other on the B ring. The twelve tested derivatives were further evaluated for antioxidant activity, wherein compound SC2 showed the highest activity. Its concentration for the 50% of maximal effect (EC50) value was approximately 1000 times greater than that of the positive controls. SC2 treatment effectively improved biochemical indicators caused by oxidative stress. Overall, compound SC2 could serve as a promising candidate for further development of a new potent COX2 inhibitor.<\/jats:p>","DOI":"10.3390\/molecules26216622","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:22:24Z","timestamp":1635805344000},"page":"6622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Investigation into the Interaction between Double Hydroxide-Based Antioxidant Benzophenone Derivatives and Cyclooxygenase 2"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-088X","authenticated-orcid":false,"given":"Yanan","family":"Qiao","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxi","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-6983","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"},{"name":"School of Public Health, Shaanxi University of Chinese Medicine, Xi\u2019an 712046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingshan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"},{"name":"Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Chinese Medicine, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107624","DOI":"10.1016\/j.pharmthera.2020.107624","article-title":"Cyclooxygenases and the cardiovascular system","volume":"217","author":"Mitchell","year":"2021","journal-title":"Pharmacol. 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