{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:24:01Z","timestamp":1791408241232,"version":"4.3.3"},"reference-count":139,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Agaves are plants used in the production of alcoholic beverages and fibers. Ever since ancient times, pre-Hispanic cultures in Mexico have used them in traditional medicine to cure different ailments. Over the years, studies of the active principles responsible for the therapeutic benefits of agaves have increased. Leaves and fibers are the main agro-wastes generated in tequila and mezcal production, while fibers are the main waste product in the textile sector. Different investigations have referred to the agro-waste from agave processing as a source of bioactive molecules called secondary metabolites (SM). Among them, phenols, flavonoids, phytosterols, and saponins have been extracted, identified, and isolated from these plants. The role of these molecules in pest control and the prospect of metabolites with the biological potential to develop novel drugs for chronic and acute diseases represent new opportunities to add value to these agro-wastes. This review aims to update the biological activities and recent applications of the secondary metabolites of the genus Agave.<\/jats:p>","DOI":"10.3390\/molecules26226789","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T09:19:21Z","timestamp":1636535961000},"page":"6789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Hunting Bioactive Molecules from the Agave Genus: An Update on Extraction and Biological Potential"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-0919","authenticated-orcid":false,"given":"Misael","family":"Berm\u00fadez-Baz\u00e1n","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C., Unidad de Tecnolog\u00eda Alimentaria, Camino Arenero 1227, El Baj\u00edo, Zapopan 45019, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-7318","authenticated-orcid":false,"given":"Gustavo Adolfo","family":"Castillo-Herrera","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C., Unidad de Tecnolog\u00eda Alimentaria, Camino Arenero 1227, El Baj\u00edo, Zapopan 45019, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Esmeralda","family":"Urias-Silvas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C., Unidad de Tecnolog\u00eda Alimentaria, Camino Arenero 1227, El Baj\u00edo, Zapopan 45019, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-5508","authenticated-orcid":false,"given":"Antonio","family":"Escobedo-Reyes","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C., Unidad de Servicios Anal\u00edticos y Metrol\u00f3gicos, Av. Normalistas No. 800, Guadalajara 44270, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2081-3335","authenticated-orcid":false,"given":"Mirna","family":"Estarr\u00f3n-Espinosa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Asistencia en Tecnolog\u00eda y Dise\u00f1o del Estado de Jalisco, A.C., Unidad de Tecnolog\u00eda Alimentaria, Camino Arenero 1227, El Baj\u00edo, Zapopan 45019, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"ref_1","first-page":"37","article-title":"El Metabolismo \u00c1cido de Las Crasul\u00e1ceas: Diversidad, Fisiolog\u00eda Ambiental y Productividad","volume":"81","author":"Andrade","year":"2007","journal-title":"Bolet\u00edn Soc. 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