{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:25:37Z","timestamp":1787981137729,"version":"build-2784847793"},"reference-count":20,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017M1A2A2049100"],"award-info":[{"award-number":["NRF-2017M1A2A2049100"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We observed an unusual formation of four-coordinate boron(III) complexes from the reaction of 1-(2-pyridinyl)-5-pyrazolone derivatives with arylboronic acids in the basic media. The exact mechanism is not clear; however, the use of unprotected boronic acid and the presence of a bidentate ligand appeared to be the key structural requirements for the transformation. The results suggest that base-promoted disproportionation of arylboronic acid with the assistance of the [N,O]-bidentate ligation of 1-(2-pyridinyl)-5-pyrazolone should take place and facilitate the formation of pyrazole diarylborinate. Experiments to obtain a deeper understanding of its mechanism are currently underway.<\/jats:p>","DOI":"10.3390\/molecules26226814","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T23:04:46Z","timestamp":1636671886000},"page":"6814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structural Requirements of 1-(2-Pyridinyl)-5-pyrazolones for Disproportionation of Boronic Acids"],"prefix":"10.3390","volume":"26","author":[{"given":"Joungmo","family":"Cho","sequence":"first","affiliation":[{"name":"Korea Research Institute of Chemical Technology, Daejeon 34114, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Subbaiah","family":"Sadu","sequence":"additional","affiliation":[{"name":"R&D Center, Molecules & Materials Co., Ltd., B-219 Daeduck BIZ Center, Daejeon 34013, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Han","sequence":"additional","affiliation":[{"name":"Korea Research Institute of Chemical Technology, Daejeon 34114, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsoo","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Life Science, Ewha Womans University, Seoul 03760, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwajeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1341-0514","authenticated-orcid":false,"given":"Kee-In","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Research Institute of Chemical Technology, Daejeon 34114, Korea"},{"name":"R&D Center, Molecules & Materials Co., Ltd., B-219 Daeduck BIZ Center, Daejeon 34013, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Karrouchi, K., Radi, S., Ramli, Y., Taoufik, J., Mabkhot, Y.N., Al-aizari, F.A., and Ansar, M. (2018). Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review. Molecules, 23.","DOI":"10.3390\/molecules23010134"},{"key":"ref_2","first-page":"1783","article-title":"Palladium-Catalyzed Peripheral Arylation of 5-Pyrazolones via Enolizable Bond Protection","volume":"11","author":"Bin","year":"2011","journal-title":"Synthesis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"22389","DOI":"10.1038\/srep22389","article-title":"A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase","volume":"6","author":"Joo","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lee, S.G., Lee, J., Kim, K.M., Lee, K.-I., Bae, Y.S., and Lee, H.J. (2019). Pharmacokinetic Study of NADPH Oxidase Inhibitor Ewha-18278, a Pyrazole Derivative. 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