{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:31:46Z","timestamp":1791919906033,"version":"4.3.4"},"reference-count":73,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-104379RB-C21  \/ AEI \/ 10.13039\/501100011033;"],"award-info":[{"award-number":["PID2019-104379RB-C21  \/ AEI \/ 10.13039\/501100011033;"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["CTQ2017-88091-P"],"award-info":[{"award-number":["CTQ2017-88091-P"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-117455GB-I00 \/ AEI \/ 10.13039\/501100011033"],"award-info":[{"award-number":["PID2020-117455GB-I00 \/ AEI \/ 10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["E07_20R"],"award-info":[{"award-number":["E07_20R"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this work, two thiourea ligands bearing a phosphine group in one arm and in the other a phenyl group (T2) or 3,5-di-CF3 substituted phenyl ring (T1) have been prepared and their coordination to Au and Ag has been studied. A different behavior is observed for gold complexes, a linear geometry with coordination only to the phosphorus atom or an equilibrium between the linear and three-coordinated species is present, whereas for silver complexes the coordination of the ligand as P^S chelate is found. The thiourea ligands and their complexes were explored against different cancer cell lines (HeLa, A549, and Jurkat). The thiourea ligands do not exhibit relevant cytotoxicity in the tested cell lines and the coordination of a metal triggers excellent cytotoxic values in all cases. In general, data showed that gold complexes are more cytotoxic than the silver compounds with T1, in particular the complexes [AuT1(PPh3)]OTf, the bis(thiourea) [Au(T1)2]OTf and the gold-thiolate species [Au(SR)T1]. In contrast, with T2 better results are obtained with silver species [AgT1(PPh3)]OTf and the [Ag(T1)2]OTf. The role played by the ancillary ligand bound to the metal is important since it strongly affects the cytotoxic activity, being the bis(thiourea) complex the most active species. This study demonstrates that metal complexes derived from thiourea can be biologically active and these compounds are promising leads for further development as potential anticancer agents.<\/jats:p>","DOI":"10.3390\/molecules26226891","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T02:42:28Z","timestamp":1637116948000},"page":"6891","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Synthesis of New Thiourea-Metal Complexes with Promising Anticancer Properties"],"prefix":"10.3390","volume":"26","author":[{"given":"Guillermo","family":"Canudo-Barreras","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH), CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, 50009 Zaragoza, Spain"},{"name":"Laboratorio de Organocat\u00e1lisis Asim\u00e9trica, Departamento de Qu\u00edmica Org\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH), CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Ortego","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH), CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabel","family":"Izaga","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH), CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-9079","authenticated-orcid":false,"given":"Isabel","family":"Marzo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Celular, Universidad de Zaragoza, C\/Pedro Cerbuna 12, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-9569","authenticated-orcid":false,"given":"Raquel P.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Laboratorio de Organocat\u00e1lisis Asim\u00e9trica, Departamento de Qu\u00edmica Org\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH), CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-0695","authenticated-orcid":false,"given":"M. Concepci\u00f3n","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH), CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"ref_1","unstructured":"(2021, August 16). An update on Cancer Deaths in the United States, Available online: https:\/\/www.cdc.gov\/cancer\/dcpc\/research\/update-on-cancer-deaths\/index.htm."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1383-5718(03)00049-4","article-title":"Genotoxicity of two anticancer drugs, gemcitabine and topotecan, in mouse bone marrow in vivo","volume":"537","author":"Aydemir","year":"2003","journal-title":"Mutat. 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