{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:01:01Z","timestamp":1791658861933,"version":"4.3.4"},"reference-count":140,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"General Director of Higher Education, Indonesian Ministry of Education, Culture, Research and Technology","award":["2021"],"award-info":[{"award-number":["2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Carica papaya (papaya) leaf extract has been used for a long time in a traditional medicine to treat fever in some infectious diseases such as dengue, malaria, and chikungunya. The development of science and technology has subsequently made it possible to provide evidence that this plant is not only beneficial as an informal medication, but also that it has scientifically proven pharmacological and toxicological activities, which have led to its formal usage in professional health care systems. The development of formulations for use in nutraceuticals and cosmeceuticals has caused this product to be more valuable nowadays. The use of good manufacturing practice (GMP) standards, along with the ease of registering this product facilitated by policies of the national government, will absolutely increase the value of papaya leaf extract as a vital nutraceutical and cosmeceutical products in the near future. In this article, we review the potential of papaya leaf extract to be a high-value commodity in terms of its health effects as well as its industrial benefits.<\/jats:p>","DOI":"10.3390\/molecules26226922","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T09:16:11Z","timestamp":1637140571000},"page":"6922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The Future of Carica papaya Leaf Extract as an Herbal Medicine Product"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-2116","authenticated-orcid":false,"given":"Maywan","family":"Hariono","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Universitas Sanata Dharma, Campus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffry","family":"Julianus","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Sanata Dharma, Campus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipang","family":"Djunarko","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Sanata Dharma, Campus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwan","family":"Hidayat","sequence":"additional","affiliation":[{"name":"PT Industri Jamu dan Sido Muncul Tbk., Soekarno Hatta Street Km. 28, Bergas, Klepu, Semarang 50552, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintang","family":"Adelya","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Sanata Dharma, Campus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friska","family":"Indayani","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Sanata Dharma, Campus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerlinda","family":"Auw","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Sanata Dharma, Campus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Namba","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Sanata Dharma, Campus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-1109","authenticated-orcid":false,"given":"Pandu","family":"Hariyono","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universitas Sanata Dharma, Campus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"ref_1","first-page":"313","article-title":"Euphorbiaceae-a critical review on plant tissue culture","volume":"10","author":"Kondamudi","year":"2009","journal-title":"Trop. 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