{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:03:17Z","timestamp":1790290997239,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We have developed a precise and accurate method for the determination of ciprofloxacin and ofloxacin in meat tissues. Our method utilizes capillary electrophoresis with a transient pseudo-isotachophoresis mechanism and liquid\u2013liquid extraction during sample preparation. For our experiment, a meat tissue sample was homogenized in pH 7.00 phosphate buffer at a ratio of 1:10 (tissue mass: buffer volume; g\/mL). The extraction of each sample was carried out twice for 15 min with 600 \u00b5L of a mixture of dichloromethane and acetonitrile at a 2:1 volume ratio. We then conducted the electrophoretic separation at a voltage of 16 kV and a temperature of 25 \u00b0C using a background electrolyte of 0.1 mol\/L phosphate\u2013borate (pH 8.40). We used the UV detection at 288 nm. The experimentally determined LOQs for ciprofloxacin and ofloxacin were 0.27 ppm (0.8 nmol\/g tissue) and 0.11 ppm (0.3 nmol\/g tissue), respectively. The calibration curves exhibited linearity over the tested concentration range of 2 to 10 nmol\/g tissue for both analytes. The relative standard deviation of the determination did not exceed 15%, and the recovery was in the range of 85\u2013115%. We used the method to analyze various meat tissues for their ciprofloxacin and ofloxacin contents.<\/jats:p>","DOI":"10.3390\/molecules26226931","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T09:16:11Z","timestamp":1637140571000},"page":"6931","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Simultaneous Determination of Ciprofloxacin and Ofloxacin in Animal Tissues with the Use of Capillary Electrophoresis with Transient Pseudo-Isotachophoresis"],"prefix":"10.3390","volume":"26","author":[{"given":"Izabella","family":"Ko\u015bka","sequence":"first","affiliation":[{"name":"Department of Environmental Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163, 90-236 Lodz, Poland"},{"name":"Doctoral School of Exact and Natural Sciences, University of Lodz, Banacha 12\/16, 90-237 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystian","family":"Purgat","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0071-1470","authenticated-orcid":false,"given":"Rafa\u0142","family":"G\u0142owacki","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6080-5762","authenticated-orcid":false,"given":"Pawe\u0142","family":"Kubalczyk","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105717","DOI":"10.1016\/j.microc.2020.105717","article-title":"Augmented spectrofluorimetric determination of certain fluoroquinolones via micellar\u2014Metal complex connection: Application to pharmaceuticals and biological fluids","volume":"160","year":"2021","journal-title":"Microchem. 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