{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:28:58Z","timestamp":1792056538657,"version":"4.4.0"},"reference-count":78,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The treatment of viral disease has become a medical challenge because of the increasing incidence and prevalence of human viral pathogens, as well as the lack of viable treatment alternatives, including plant-derived strategies. This review attempts to investigate the trends of research on in vitro antiviral effects of curcumin against different classes of human viral pathogens worldwide. Various electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar were searched for published English articles evaluating the anti-viral activity of curcumin. Data were then extracted and analyzed. The forty-three studies (published from 1993 to 2020) that were identified contain data for 24 different viruses. The 50% cytotoxic concentration (CC50), 50% effective\/inhibitory concentration (EC50\/IC50), and stimulation index (SI) parameters showed that curcumin had antiviral activity against viruses causing diseases in humans. Data presented in this review highlight the potential antiviral applications of curcumin and open new avenues for further experiments on the clinical applications of curcumin and its derivatives.<\/jats:p>","DOI":"10.3390\/molecules26226994","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T21:00:50Z","timestamp":1637528450000},"page":"6994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Antiviral Therapeutic Potential of Curcumin: An Update"],"prefix":"10.3390","volume":"26","author":[{"given":"Abdollah","family":"Ardebili","sequence":"first","affiliation":[{"name":"Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Iran"},{"name":"Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Pouriayevali","sequence":"additional","affiliation":[{"name":"Department of Arboviruses and Viral Hemorrhagic Fevers (National Ref Lab), Pasteur Institute of Iran, Tehran 1316943551, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Aleshikh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-0030","authenticated-orcid":false,"given":"Marziyeh","family":"Zahani","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4829-2255","authenticated-orcid":false,"given":"Mehdi","family":"Ajorloo","sequence":"additional","affiliation":[{"name":"Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad 6813833946, Iran"},{"name":"Department of Virology, Lorestan University of Medical Sciences, Khorramabad 6813833946, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahdieh","family":"Izanloo","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Golestan University, Gorgan 4934174515, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolghasem","family":"Siyadatpanah","sequence":"additional","affiliation":[{"name":"Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Razavi Nikoo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran"},{"name":"Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-7788","authenticated-orcid":false,"given":"Polrat","family":"Wilairatana","sequence":"additional","affiliation":[{"name":"Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri (URCA), Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"ref_1","unstructured":"(2021, November 07). Available online: http:\/\/www.emro.who.int\/health-topics.html."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lorestani, N., Moradi, A., Teimoori, A., Masodi, M., Khanizadeh, S., Hassanpour, M., Javid, N., Ardebili, A., Tabarraei, A., and Nikoo, H.R. (2019). Molecular and serologic characterization of rotavirus from children with acute gastroenteritis in northern Iran, Gorgan. Bmc Gastroenterol., 19.","DOI":"10.1186\/s12876-019-1025-x"},{"key":"ref_3","first-page":"186864","article-title":"A review on antibacterial, antiviral, and antifungal activity of curcumin","volume":"2014","author":"Hassandarvish","year":"2014","journal-title":"Biomed Res. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.1086\/313849","article-title":"Factors affecting adherence to antiretroviral therapy","volume":"30","author":"Chesney","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2007.07.003","article-title":"Discovery and development of antiviral drugs for biodefense: Experience of a small biotechnology company","volume":"77","author":"Bolken","year":"2008","journal-title":"Antivir. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/S0140-6736(03)15022-2","article-title":"Treatment of antiretroviral-drug-resistant HIV-1 infection","volume":"362","author":"Deeks","year":"2003","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1136\/bmj.331.7507.10","article-title":"Use of antiviral drug in poultry is blamed for drug resistant strains of avian flu","volume":"331","author":"Parry","year":"2005","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1128\/AAC.00426-06","article-title":"Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood","volume":"51","author":"Schnitzler","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_9","first-page":"35","article-title":"Herbal medicine","volume":"78","author":"Meuss","year":"2000","journal-title":"Curr. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Connell, B.J., Chang, S.-Y., Prakash, E., Yousfi, R., Mohan, V., Posch, W., Wilflingseder, D., Moog, C., Kodama, E.N., and Clayette, P. (2016). A cinnamon-derived procyanidin compound displays anti-hiv-1 activity by blocking heparan sulfate-and co-receptor-binding sites on gp120 and reverses T cell exhaustion via impeding tim-3 and PD-1 upregulation. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165386"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/bph.12009","article-title":"Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea","volume":"168","author":"Steinmann","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3389\/fmicb.2019.00912","article-title":"Anti-infective properties of the golden spice curcumin","volume":"10","author":"Praditya","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_13","first-page":"44","article-title":"Turmeric and curcumin: Biological actions and medicinal applications","volume":"87","author":"Chattopadhyay","year":"2004","journal-title":"Curr. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jff.2017.12.017","article-title":"Antiviral potential of curcumin","volume":"40","author":"Mathew","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_15","first-page":"11","article-title":"Turmeric, curcumin and our life:A review","volume":"1","author":"Lal","year":"2012","journal-title":"Bull Env. Pharm. Life Sci"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.foodres.2005.02.021","article-title":"Separation and determination of the physico-chemical characteristics of curcumin, demethoxycurcumin and bisdemethoxycurcumin","volume":"38","author":"Cherubino","year":"2005","journal-title":"Food Res. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.apsb.2014.06.006","article-title":"Curcumin inhibits the replication of enterovirus 71 in vitro","volume":"4","author":"Qin","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"27539","DOI":"10.1038\/srep27539","article-title":"Curcumin inhibits HIV-1 by promoting Tat protein degradation","volume":"6","author":"Ali","year":"2016","journal-title":"Sci Rep"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0006-2952(95)98514-A","article-title":"Inhibition of human immunodeficiency virus type-1 integrase by curcumin","volume":"49","author":"Mazumder","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0923-2516(97)86899-9","article-title":"Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat","volume":"149","author":"Barthelemy","year":"1998","journal-title":"Res. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tomita, M., Kawakami, H., Uchihara, J.-N., Okudaira, T., Masuda, M., Takasu, N., Matsuda, T., Ohta, T., Tanaka, Y., and Mori, N. (2006). RETRACTED: Curcumin Suppresses Constitutive Activation of AP-1 by Downregulation of JunD Protein in HTLV-1-Infected T-Cell Lines, Elsevier.","DOI":"10.1016\/j.leukres.2005.08.004"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1128\/JVI.02028-06","article-title":"Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication","volume":"81","author":"Si","year":"2007","journal-title":"J. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.virol.2007.11.028","article-title":"Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300\/CBP histone acetyltransferase activity","volume":"373","author":"Kutluay","year":"2008","journal-title":"Virology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jep.2009.04.046","article-title":"Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication","volume":"124","author":"Kim","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11481-009-9158-2","article-title":"Curcumin protects neuronal cells from Japanese encephalitis virus-mediated cell death and also inhibits infective viral particle formation by dysregulation of ubiquitin\u2013proteasome system","volume":"4","author":"Dutta","year":"2009","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.febslet.2010.04.067","article-title":"Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1\u03b1","volume":"584","author":"Rechtman","year":"2010","journal-title":"Febs Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.foodchem.2009.09.011","article-title":"Curcumin inhibits influenza virus infection and haemagglutination activity","volume":"119","author":"Chen","year":"2010","journal-title":"Food Chem."},{"key":"ref_28","first-page":"1934578X1000501220","article-title":"Evaluation of antiviral activities of curcumin derivatives against HSV-1 in Vero cell line","volume":"5","author":"Zandi","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.febslet.2009.12.019","article-title":"Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway","volume":"584","author":"Kim","year":"2010","journal-title":"Febs Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1002\/jcp.22691","article-title":"HDAC1\/NF\u03baB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation","volume":"226","author":"Zhang","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_31","first-page":"30","article-title":"Activity of curcumin against human cytomegalovirus in vitro","volume":"6","author":"Lv","year":"2012","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3892\/ijmm.2012.1096","article-title":"Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT","volume":"30","author":"Chen","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"33198","DOI":"10.1074\/jbc.M112.356535","article-title":"Curcumin inhibits Rift Valley fever virus replication in human cells","volume":"287","author":"Narayanan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Chen, T.-Y., Chen, D.-Y., Wen, H.-W., Ou, J.-L., Chiou, S.-S., Chen, J.-M., Wong, M.-L., and Hsu, W.-L. (2013). Inhibition of enveloped viruses infectivity by curcumin. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062482"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Obata, K., Kojima, T., Masaki, T., Okabayashi, T., Yokota, S., Hirakawa, S., Nomura, K., Takasawa, A., Murata, M., and Tanaka, S. (2013). Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070225"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lv, Y., An, Z., Chen, H., Wang, Z., and Liu, L. (2014). Mechanism of curcumin resistance to human cytomegalovirus in HELF cells. Bmc Complementary Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-284"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.etap.2014.04.017","article-title":"Protective effect of curcumin against cytomegalovirus infection in Balb\/c mice","volume":"37","author":"Lv","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4149\/av_2015_03_221","article-title":"Curcumin inhibits bovine herpesvirus type 1 entry into MDBK cells","volume":"59","author":"Zhu","year":"2015","journal-title":"Acta Virol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/gutjnl-2012-304299","article-title":"Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells","volume":"63","author":"Colpitts","year":"2014","journal-title":"Gut"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ferreira, V.H., Nazli, A., Dizzell, S.E., Mueller, K., and Kaushic, C. (2015). The anti-inflammatory activity of curcumin protects the genital mucosal epithelial barrier from disruption and blocks replication of HIV-1 and HSV-2. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124903"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.fsi.2015.03.042","article-title":"Identification of regulators of the early stage of viral hemorrhagic septicemia virus infection during curcumin treatment","volume":"45","author":"Jeong","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"ref_42","first-page":"5051","article-title":"Inhibition of HIV-1 by curcumin A, a novel curcumin analog","volume":"9","author":"Kumari","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4236\/aim.2016.64027","article-title":"Inhibition of curcumin-treated Herpes Simplex virus 1 and 2 in vero cells","volume":"6","author":"Flores","year":"2016","journal-title":"Adv. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12560-016-9255-3","article-title":"Curcumin-mediated photodynamic inactivation of norovirus surrogates","volume":"8","author":"Randazzo","year":"2016","journal-title":"Food Environ. Virol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.antiviral.2015.11.007","article-title":"Curcumin and Boswellia serrata gum resin extract inhibit chikungunya and vesicular stomatitis virus infections in vitro","volume":"125","author":"Weidner","year":"2016","journal-title":"Antivir. Res."},{"key":"ref_46","first-page":"29","article-title":"The antiviral effects of curcumin nanomicelles on the attachment and entry of hepatitis C virus","volume":"11","author":"Naseri","year":"2017","journal-title":"Iran. J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"622-11","DOI":"10.1096\/fasebj.31.1_supplement.622.11","article-title":"Effects of Curcumin on Vesicular Stomatitis Virus (VSV) Infection and Dicer-1 Expression","volume":"31","author":"Ahmed","year":"2017","journal-title":"Faseb J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2017.03.014","article-title":"Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding","volume":"142","author":"Mounce","year":"2017","journal-title":"Antivir. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.3748\/wjg.v23.i34.6252","article-title":"Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation","volume":"23","author":"Wei","year":"2017","journal-title":"World, J. Gastroenterol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/08820139.2017.1371908","article-title":"Immunomodulatory activities of curcumin-stabilized silver nanoparticles:Efficacy as an antiretroviral therapeutic","volume":"46","author":"Sharma","year":"2017","journal-title":"Immunol. Investig."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Huang, H.-I., Chio, C.-C., and Lin, J.-Y. (2018). Inhibition of EV71 by curcumin in intestinal epithelial cells. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191617"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"15740","DOI":"10.1002\/jcb.28843","article-title":"Curcumin increased the expression of c-FLIP in HTLV-1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) patients","volume":"120","author":"Poursina","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.antiviral.2018.12.002","article-title":"Inhibition of dengue virus by curcuminoids","volume":"162","author":"Balasubramanian","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.antiviral.2019.04.011","article-title":"Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis","volume":"167","author":"Li","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.colsurfb.2019.04.057","article-title":"Multifunctional mesoporous curcumin encapsulated iron-phenanthroline nanocluster: A new Anti-HIV agent","volume":"180","author":"Sharma","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/2211738507666191210163408","article-title":"Antiviral action of curcumin encapsulated in nanoemulsion against four serotypes of dengue virus","volume":"8","author":"Nabila","year":"2020","journal-title":"Pharm. Nanotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1099\/jgv.0.001466","article-title":"Antiviral and virucidal effects of curcumin on transmissible gastroenteritis virus in vitro","volume":"101","author":"Li","year":"2020","journal-title":"J. Gen. Virol."},{"key":"ref_58","first-page":"13","article-title":"Curcumin Inhibits Replication of Human Parainfluenza Virus Type 3 by Affecting Viral Inclusion Body Formation","volume":"2021","author":"Zhang","year":"2021","journal-title":"Biomed Res. Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"19125","DOI":"10.1038\/s41598-021-98243-x","article-title":"Curcumin inhibited hepatitis B viral entry through NTCP binding","volume":"11","author":"Thongsri","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"41","DOI":"10.22146\/ijbiotech.60174","article-title":"Antiviral activities of curcumin and 6-gingerol against infection of four dengue virus serotypes in A549 human cell line in vitro","volume":"26","author":"Halim","year":"2021","journal-title":"Indones. J. Biotechnol."},{"key":"ref_61","first-page":"1934578X1801301204","article-title":"Antiviral activities of curcuma genus against hepatitis C virus","volume":"13","author":"Wahyuni","year":"2018","journal-title":"Nat. Prod. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Gao, Y., Tai, W., Wang, N., Li, X., Jiang, S., Debnath, A.K., Du, L., and Chen, S. (2019). Identification of novel natural products as effective and broad-spectrum anti-Zika virus inhibitors. Viruses, 11.","DOI":"10.3390\/v11111019"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fvets.2019.00038","article-title":"Key gaps in the knowledge of the porcine respiratory reproductive syndrome virus (PRRSV)","volume":"6","author":"Montoya","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1099\/vir.0.79958-0","article-title":"Active NF-\u03baB signalling is a prerequisite for influenza virus infection","volume":"85","author":"Nimmerjahn","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12272-020-01230-5","article-title":"3D-quantitative structure\u2013activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase","volume":"43","author":"Lai","year":"2020","journal-title":"Arch. Pharmacal Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1177\/1074248413503044","article-title":"Curcumin protects mice from coxsackievirus B3-induced myocarditis by inhibiting the phosphatidylinositol 3 kinase\/Akt\/nuclear factor-\u03baB pathway","volume":"18","author":"Song","year":"2013","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4149\/av_2018_407","article-title":"Combination of virotherapy with VSV and tumor vaccination significantly enhances the efficacy of antitumor therapy","volume":"62","author":"Sobhanimonfared","year":"2018","journal-title":"Acta Virol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/ptr.6738","article-title":"Potential effects of curcumin in the treatment of COVID-19 infection","volume":"34","author":"Zahedipour","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.virol.2021.06.004","article-title":"Study on SARS-CoV-2 strains in Iran reveals potential contribution of co-infection with and recombination between different strains to the emergence of new strains","volume":"526","author":"Taghizadeh","year":"2021","journal-title":"Virology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s13337-020-00598-8","article-title":"Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor","volume":"31","author":"Maurya","year":"2020","journal-title":"Virusdisease"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"153317","DOI":"10.1016\/j.phymed.2020.153317","article-title":"Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication","volume":"85","author":"Kumar","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s43094-020-00126-x","article-title":"Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): An in silico approach","volume":"6","author":"Rajagopal","year":"2020","journal-title":"Future J. Pharm. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Yang, M., Lee, G., Si, J., Lee, S.-J., You, H.J., and Ko, G. (2016). Curcumin shows antiviral properties against norovirus. Molecules, 21.","DOI":"10.3390\/molecules21101401"},{"key":"ref_74","first-page":"367","article-title":"Functions of adenovirus E1A","volume":"5","author":"Berk","year":"1986","journal-title":"Cancer Surv."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Jennings, M.R., and Parks, R.J. (2020). Antiviral Effects of Curcumin on Adenovirus Replication. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101524"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Vitali, D., Bagri, P., Wessels, J.M., Arora, M., Ganugula, R., Parikh, A., Mandur, T., Felker, A., Garg, S., and Kumar, M. (2020). Curcumin can decrease tissue inflammation and the severity of HSV-2 infection in the female reproductive mucosa. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010337"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"10384","DOI":"10.1021\/bi701013n","article-title":"Curcumin is a modulator of bilayer material properties","volume":"46","author":"Ingolfsson","year":"2007","journal-title":"Biochemistry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pdpdt.2015.06.005","article-title":"Virucidal efficacy of treatment with photodynamically activated curcumin on murine norovirus bio-accumulated in oysters","volume":"12","author":"Wu","year":"2015","journal-title":"Photodiagnosis Photodyn. Ther."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/22\/6994\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:33:01Z","timestamp":1760167981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/22\/6994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,19]]},"references-count":78,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["molecules26226994"],"URL":"https:\/\/doi.org\/10.3390\/molecules26226994","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,19]]}}}