{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:10Z","timestamp":1787029090706,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:00:00Z","timestamp":1637366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Maesa membranacea A. DC. (Primulaceae) is a plant species that has been frequently used by practitioners of the traditional ethnobotany knowledge from northern and central Vietnam. However, the chemical constituents of the plant remained unknown until recently. Chromatographic separation of a chloroform-soluble fraction of extract from leaves of M. membranacea led to the isolation of two new polyesterified ursane triterpenes (1\u20132) and two known apocarotenoids: (+)-dehydrovomifoliol (3) and (+)-vomifoliol (4). The chemical structures of the undescribed triterpenoids were elucidated using 1D and 2D MNR and HRESIMS spectral data as 2\u03b1,6\u03b2,22\u03b1-triacetoxy-11\u03b1-(2-methylbutyryloxy)-urs-12-ene-3\u03b1,20\u03b2-diol (1) and 2\u03b1,6\u03b2,22\u03b1-triacetoxy-urs-12-ene-3\u03b1,11\u03b1,20\u03b2-triol (2). The newly isolated triterpenoids were tested for their cytotoxic activity in vitro against two melanoma cell lines (HTB140 and A375), normal skin keratinocytes (HaCaT), two colon cancer cell lines (HT29 and Caco-2), two prostate cancer cell lines (DU145 and PC3) and normal prostate epithelial cells (PNT-2). Doxorubicin was used as a reference cytostatic drug. The 2\u03b1,6\u03b2,22\u03b1-triacetoxy-11\u03b1-(2-methylbutyryloxy)-urs-12-ene-3\u03b1,20\u03b2-diol demonstrated cytotoxic activity against prostate cancer cell lines (Du145\u2014IC50 = 35.8 \u00b5g\/mL, PC3\u2014IC50 = 41.6 \u00b5g\/mL), and at a concentration of 100 \u00b5g\/mL reduced viability of normal prostate epithelium (PNT-2) cells by 41%.<\/jats:p>","DOI":"10.3390\/molecules26227013","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T21:00:50Z","timestamp":1637528450000},"page":"7013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New Polyesterified Ursane Derivatives from Leaves of Maesa membranacea and Their Cytotoxic Activity"],"prefix":"10.3390","volume":"26","author":[{"given":"Klaudia","family":"Michalska","sequence":"first","affiliation":[{"name":"Maj Institute of Pharmacology, Polish Academy of Sciences, Sm\u0119tna Street 12, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-8646","authenticated-orcid":false,"given":"Agnieszka","family":"Galanty","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Collegium Medicum, Jagiellonian University, Medyczna Street 9, 30-688 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-4187","authenticated-orcid":false,"given":"Thanh Nguyen","family":"Le","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 1000000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-5940","authenticated-orcid":false,"given":"Janusz","family":"Malarz","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology, Polish Academy of Sciences, Sm\u0119tna Street 12, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Quoc","family":"Vuong","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 1000000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Cuong","family":"Pham","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 1000000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-2072","authenticated-orcid":false,"given":"Anna","family":"Stojakowska","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology, Polish Academy of Sciences, Sm\u0119tna Street 12, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,20]]},"reference":[{"key":"ref_1","unstructured":"WFO 2021 (2021, May 05). 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