{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:39:14Z","timestamp":1787899154058,"version":"build-2784847793"},"reference-count":99,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010100","name":"University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice","doi-asserted-by":"publisher","award":["PROFISH (CZ.02.1.01 \/ 0.0 \/ 0.0 \/ 16_019 \/ 0000869)"],"award-info":[{"award-number":["PROFISH (CZ.02.1.01 \/ 0.0 \/ 0.0 \/ 16_019 \/ 0000869)"]}],"id":[{"id":"10.13039\/100010100","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["CENAKVA project (LM2018099)"],"award-info":[{"award-number":["CENAKVA project (LM2018099)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; C20H30O5) isolated from Andrographis paniculate (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster.<\/jats:p>","DOI":"10.3390\/molecules26227036","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T21:00:50Z","timestamp":1637528450000},"page":"7036","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health"],"prefix":"10.3390","volume":"26","author":[{"given":"Archana","family":"Mishra","sequence":"first","affiliation":[{"name":"South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, Institute of Aquaculture and Protection of Waters, University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice, Na S\u00e1dk\u00e1ch 1780, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haq Abdul","family":"Shaik","sequence":"additional","affiliation":[{"name":"Institute of Entomology, Biology Centre, Czech Academy of Science, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"},{"name":"Department of Parasitology, Faculty of Science, University of South Bohemia, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Sinha","sequence":"additional","affiliation":[{"name":"Institute of Plant Genetics, Polish Academy of Sciences, 34 Strzeszynska Street, 60-479 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-1434","authenticated-orcid":false,"given":"Bakht Ramin","family":"Shah","sequence":"additional","affiliation":[{"name":"South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, Institute of Aquaculture and Protection of Waters, University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice, Na S\u00e1dk\u00e1ch 1780, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S2222-1808(14)60509-0","article-title":"Harnessing the medicinal properties of andrographis paniculata for diseases and beyond: A review of its phytochemistry and pharmacology","volume":"4","author":"Okhuarobo","year":"2014","journal-title":"Asian Pac. 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