{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:17:40Z","timestamp":1783977460235,"version":"3.55.0"},"reference-count":55,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004787","name":"The Research Council","doi-asserted-by":"publisher","award":["BFP\/RGP\/CBS\/18\/011"],"award-info":[{"award-number":["BFP\/RGP\/CBS\/18\/011"]}],"id":[{"id":"10.13039\/501100004787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In continuation of phytochemical investigations of the methanolic extract of Dictyopteris hoytii, we have obtained twelve compounds (1\u201312) through column chromatography. Herein, three compounds, namely, dimethyl 2-bromoterepthalate (3), dimethyl 2,6-dibromoterepthalate (4), and (E)-3-(4-(dimethoxymethyl)phenyl) acrylic acid (5) are isolated for the first time as a natural product, while the rest of the compounds (1, 2, 6\u201312) are known and isolated for the first time from this source. The structures of the isolated compounds were elucidated by advanced spectroscopic 1D and 2D NMR techniques including 1H, 13C, DEPT, HSQC, HMBC, COSY, NEOSY, and HR-MS and comparison with the reported literature. Furthermore, eight compounds (13\u201320) previously isolated by our group from the same source along with the currently isolated compounds (1\u201312) were screened against the CA-II enzyme. All compounds, except 6, 8, 14, and 17, were evaluated for in vitro bovine carbonic anhydrase-II (CA-II) inhibitory activity. Eventually, eleven compounds (1, 4, 5, 7, 9, 10, 12, 13, 15, 18, and 19) exhibited significant inhibitory activity against CA-II with IC50 values ranging from 13.4 to 71.6 \u03bcM. Additionally, the active molecules were subjected to molecular docking studies to predict the binding behavior of those compounds. It was observed that the compounds exhibit the inhibitory potential by specifically interacting with the ZN ion present in the active site of CA-II. In addition to ZN ion, two residues (His94 and Thr199) play an important role in binding with the compounds that possess a carboxylate group in their structure.<\/jats:p>","DOI":"10.3390\/molecules26237074","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:01:11Z","timestamp":1638309671000},"page":"7074","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New Carbonic Anhydrase-II Inhibitors from Marine Macro Brown Alga Dictyopteris hoytii Supported by In Silico Studies"],"prefix":"10.3390","volume":"26","author":[{"given":"Kashif","family":"Rafiq","sequence":"first","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajmal","family":"Khan","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1563-225X","authenticated-orcid":false,"given":"Najeeb","family":"Ur Rehman","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobia Ahsan","family":"Halim","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-2046","authenticated-orcid":false,"given":"Majid","family":"Khan","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Nizwa 616, Oman"},{"name":"H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0045-5294","authenticated-orcid":false,"given":"Liaqat","family":"Ali","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Nizwa 616, Oman"},{"name":"Department of Chemistry, University of Mianwali, Mianwali 42200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Hilal Al-Balushi","sequence":"additional","affiliation":[{"name":"Oman Animal and Plant Genetic Resources Center, P.O. Box 92, Muscat 123, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitham Khamis","family":"Al-Busaidi","sequence":"additional","affiliation":[{"name":"Oman Animal and Plant Genetic Resources Center, P.O. Box 92, Muscat 123, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-5942","authenticated-orcid":false,"given":"Ahmed","family":"Al-Harrasi","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Louren\u00e7o-Lopes, C., Fraga-Corral, M., Jimenez-Lopez, C., Pereira, A.G., Garcia-Oliveira, P., Carpena, M., Prieto, M.A., and Simal-Gandara, J. (2020). Metabolites from Macroalgae and Its Applications in the Cosmetic Industry: A Circular Economy Approach. Resources, 9.","DOI":"10.3390\/resources9090101"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Leandro, A., Pereira, L., and Gon\u00e7alves, A.M.M. (2020). Diverse Applications of Marine Macroalgae. Mar. Drugs, 18.","DOI":"10.3390\/md18010017"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Biris-Dorhoi, E.-S., Michiu, D., Pop, C.R., Rotar, A.M., Tofana, M., Pop, O.L., Socaci, S.A., and Farcas, A.C. (2020). Macroalgae\u2014A Sustainable Source of Chemical Compounds with Biological Activities. Nutrients, 12.","DOI":"10.3390\/nu12103085"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Silva, A., Silva, S.A., Carpena, M., Garcia-Oliveira, P., Gull\u00f3n, P., Barroso, M.F., Prieto, M.A., and Simal-Gandara, J. (2020). Macroalgae as a Source of Valuable Antimicrobial Compounds: Extraction and Applications. Antibiotics, 9.","DOI":"10.3390\/antibiotics9100642"},{"key":"ref_5","first-page":"27","article-title":"Bio-oil Product from Wild Brown Macro-algae Dunggandunggan (Padinasp) in Asturias and Carmen, Cebu, Philippines","volume":"3","author":"Melendres","year":"2017","journal-title":"Int. J. Med. Plants Nat. Prod."},{"key":"ref_6","first-page":"20","article-title":"Antibacterial Activity of the Extracts of Marine Red and Brown","volume":"5","author":"Rajasulochana","year":"2009","journal-title":"J. Am. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1039\/c3np70057g","article-title":"Biogeography and biodiscovery hotspots of macroalgal marine natural products","volume":"30","author":"Leal","year":"2013","journal-title":"Nat. Prod. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1039\/C9NP00069K","article-title":"Marine natural products","volume":"37","author":"Carroll","year":"2020","journal-title":"Nat. Prod. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1021\/ja00741a068","article-title":"Isolation and structure determination of dictyopterenes C\u2019 and D\u2019 from Dictyopteris. Stereospecificity in the cope rearrangement of dictyopterenes A and B","volume":"93","author":"Moore","year":"1971","journal-title":"J. Am. Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s004420000546","article-title":"Chemical defense of brown algae (Dictyopteris spp.) against the herbivorous amphipod Ampithoe longimana","volume":"126","author":"Schnitzler","year":"2001","journal-title":"Oecologia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bjp.2018.01.005","article-title":"An overview of odoriferous marine seaweeds of the Dictyopteris genus: Insights into their chemical diversity, biological potential and ecological roles","volume":"28","author":"Zatelli","year":"2018","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.phytochem.2017.11.013","article-title":"PTP1B inhibitory and cytotoxic C-24 epimers of \u039428-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes","volume":"146","author":"Feng","year":"2018","journal-title":"Phytochemistry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/md7030355","article-title":"Brominated Selinane Sesquiterpenes from the Marine Brown Alga Dictyopteris divaricata","volume":"7","author":"Ji","year":"2009","journal-title":"Mar. Drugs"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/np060076u","article-title":"Minor sesquiterpenes with new carbon skeletons from the brown alga Dictyopteris divaricata","volume":"69","author":"Song","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Rehman, N.U., Rafiq, K., Khan, A., Halim, S.A., Ali, L., Al-Saady, N., Al-Balushi, A.H., Al-Busaidi, H.K., and Al-Harrasi, A. (2019). \u03b1-Glucosidase inhibition and molecular docking studies of natural brominated metabolites from marine macro brown alga Dictyopteris hoytii. Mar. Drugs, 17.","DOI":"10.3390\/md17120666"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0031-9422(90)80058-O","article-title":"A germacrane-type sesquiterpene from the brown alga Dictyopteris divaricata","volume":"29","author":"Segawa","year":"1990","journal-title":"Phytochemistry"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zbakh, H., Zub\u00eda, E., De Los Reyes, C., Calder\u00f3n-Monta\u00f1o, J.M., and Motilva, V. (2020). Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29. Foods, 9.","DOI":"10.3390\/foods9030300"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1021\/np040099d","article-title":"Cadinane sesquiterpenes from the brown alga Dictyopteris divaricata","volume":"67","author":"Song","year":"2004","journal-title":"J. Nat. Prod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0031-9422(95)00651-6","article-title":"Cyclozonarone, a sesquiterpene-substituted benzoquinone derivative from the brown alga Dictyopteris undulata","volume":"41","author":"Kurata","year":"1996","journal-title":"Phytochemistry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1021\/np040227y","article-title":"Norsesquiterpenes from the brown alga Dictyopteris divaricata","volume":"68","author":"Song","year":"2005","journal-title":"J. Nat. Prod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1021\/jo00929a013","article-title":"Odoriferous C11 hydrocarbons from Hawaiian Dictyopteris","volume":"39","author":"Moore","year":"1974","journal-title":"J. Org. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1021\/acs.jnatprod.5b01031","article-title":"Disulfides with Anti-inflammatory Activity from the Brown Alga Dictyopteris membranacea","volume":"79","author":"Dimou","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.bbrc.2015.01.059","article-title":"Zonarol, a sesquiterpene from the brown algae Dictyopteris undulata, provides neuroprotection by activating the Nrf2\/ARE pathway","volume":"457","author":"Shimizu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","first-page":"216","article-title":"Antimicrobial, antioxidant and alginate potentials of Dictyopteris polypodioides (Dictyotales, Phaeophyceae) from the Moroccan Atlantic coast","volume":"8","author":"Belattmania","year":"2016","journal-title":"Der Pharma Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3923\/ijp.2009.298.306","article-title":"In vitro cytotoxic activity of Sargassum thunbergii and Dictyopteris divaricata (Jeju seaweeds) on the HL-60 tumour cell line","volume":"5","author":"Kim","year":"2009","journal-title":"Int. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"103557","DOI":"10.1016\/j.bioorg.2019.103557","article-title":"Structure-activity relationship of human carbonic anhydrase-II inhibitors: Detailed insight for future development as anti-glaucoma agents","volume":"95","author":"Ghorai","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s00284-010-9801-4","article-title":"Characterization of Urease and Carbonic Anhydrase Producing Bacteria and Their Role in Calcite Precipitation","volume":"62","author":"Achal","year":"2010","journal-title":"Curr. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsps.2019.11.001","article-title":"Identification of non-alkaloid natural compounds of Angelica purpurascens (Av\u00e9-Lall.) Gilli. (Apiaceae) with cholinesterase and carbonic anhydrase inhibition potential","volume":"28","author":"Karakaya","year":"2020","journal-title":"Saudi Pharm. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543776.2013.794788","article-title":"Antiglaucoma carbonic anhydrase inhibitors: A patent review","volume":"23","author":"Masini","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1021\/acs.jafc.6b02004","article-title":"Active Components of Essential Oils as Anti-Obesity Potential Drugs Investigated by in Silico Techniques","volume":"64","author":"Costa","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3109\/14756366.2012.702344","article-title":"Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia","volume":"28","author":"Muhammad","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"111350","DOI":"10.1039\/C6RA24064J","article-title":"Synthesis and solvent-free polymerisation of vinyl terephthalate for application as an anode material in organic batteries","volume":"6","author":"Nauroozi","year":"2016","journal-title":"RSC Adv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9449","DOI":"10.1039\/c3cc46105j","article-title":"A facile synthesis of UiO-66{,} UiO-67 and their derivatives","volume":"49","author":"Katz","year":"2013","journal-title":"Chem. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"o1059","DOI":"10.1107\/S1600536811011718","article-title":"Dimethyl 2,5-bis-(5-hexyl-thio-phen-2-yl)benzene-1,4-dioate","volume":"67","author":"Song","year":"2011","journal-title":"Acta Crystallogr. Sect. E Struct. Rep. Online"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1039\/C9QM00314B","article-title":"The crucial role of end group planarity for fused-ring electron acceptors in organic solar cells","volume":"3","author":"Rech","year":"2019","journal-title":"Mater. Chem. Front."},{"key":"ref_36","unstructured":"Daluge, S.M., Wolberg, G., Livingston, D.A., and SmithKline Beecham Corp (1998). Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-yl) Phenyl Derivatives, Their Preparation and Their Use in the Treatment of Inflammatory Conditions and Immune Disorders. ((WO\/1998\/035966)), US Patent."},{"key":"ref_37","unstructured":"Lehmann-Lintz, T., Lustenberger, P., J\u00fcrgen Roth, G., Schindler, M., Thomas, L., Georg Mueller, S., Stenkamp, D., Lotz, R.R.H., and Rudolf, K. (2005). 3-(4-piperidine-1ylmethyl-phenyl)-propion Acid-phenylamide-derivatives and Related Compounds Used in the Form of mch Antagonists (Melanine Concentrating Hormone) for Treating Eating Disorders. ((WO2005063239A1)), US Patent."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.3891\/acta.chem.scand.16-2421","article-title":"Ozonolysis of Phenols. III. 1- and 2-Naphthol","volume":"16","author":"Bernatek","year":"1962","journal-title":"Acta Chem. Scand."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1021\/jm00320a033","article-title":"Synthesis of Substituted \u03b2-Lactams","volume":"9","author":"Chatterjee","year":"1966","journal-title":"J. Med. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.bse.2007.08.016","article-title":"Apo-fucoxanthinoids and loliolide from the brown alga Cladostephus spongiosus f. verticillatus (Heterokonta, Sphacelariales)","volume":"36","author":"Hattab","year":"2008","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1021\/np50121a020","article-title":"Isolation of Apo-9\u2019-fucoxanthinone from the Cultured Marine Dinoflagellate Amphidinium sp.","volume":"58","author":"Doi","year":"1995","journal-title":"J. Nat. Prod."},{"key":"ref_42","first-page":"33","article-title":"Studies on the chemical constituents of Callicarpa bodinieri Levl","volume":"13","author":"Fengzhi","year":"2001","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1021\/jf960708q","article-title":"Nonpolar Lipids of Amaranthus palmeri S. Wats. 2. Unsaturated Esters and Free Fatty Acids, Sterols, and Triterpenols","volume":"45","author":"Dailey","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40816-020-00236-2","article-title":"In vitro antidiabetic potentials, antioxidant activities and phytochemical profile of african black pepper (Piper guineense)","volume":"6","author":"Sulaimon","year":"2020","journal-title":"Clin. Phytoscience"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4314\/bcse.v16i1.20952","article-title":"Triterpenes from the resin of Boswellia neglecta","volume":"16","author":"Dekebo","year":"2002","journal-title":"Bull. Chem. Soc. Ethiop."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ur Rehman, N., Halim, S.A., Al-Azri, M., Khan, M., Khan, A., Rafiq, K., Al-Rawahi, A., Csuk, R., and Al-Harrasi, A. (2020). Triterpenic Acids as Non-Competitive \u03b1-Glucosidase Inhibitors from Boswellia elongata with Structure-Activity Relationship: In Vitro and In Silico Studies. Biomolecules, 10.","DOI":"10.3390\/biom10050751"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijms.2014.05.004","article-title":"A Proton Transfer Reaction-Quadrupole interface Time-Of-Flight Mass Spectrometer (PTR-QiTOF): High speed due to extreme sensitivity","volume":"368","author":"Sulzer","year":"2014","journal-title":"Int. J. Mass Spectrom."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"19075","DOI":"10.1039\/C8RA01968A","article-title":"Fabrication of two dual-functionalized covalent organic polymers through heterostructural mixed linkers and their use as cationic dye adsorbents","volume":"8","author":"Dong","year":"2018","journal-title":"RSC Adv."},{"key":"ref_49","first-page":"2503","article-title":"Chemical constituents from root bark of Tripterygium hypoglaucum","volume":"36","author":"Liu","year":"2011","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_50","first-page":"614","article-title":"Isolation and characterization of n-hexadecanoic acid from Canthium parviflorum leaves","volume":"8","author":"Krishnan","year":"2016","journal-title":"J. Chem. Pharm. Res."},{"key":"ref_51","first-page":"1323","article-title":"Isolation, Characterization and Bioactivities of Sambucus wightiana derived Dotriacontanoic acid","volume":"1","author":"Mir","year":"2019","journal-title":"Int. J. Trend Sci. Res. Dev."},{"key":"ref_52","first-page":"791","article-title":"Isolation, Characterization and Antibacterial Evaluation on Long Chain Fatty Acids from Limnophila polystachya Benth","volume":"23","author":"KALIMUTHU","year":"2011","journal-title":"Asian J. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.bmc.2010.01.076","article-title":"Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I\u2013XIV with a series of natural product polyphenols and phenolic acids","volume":"18","author":"Innocenti","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref_54","unstructured":"Chemical Computing Group Inc. (2014). Molecular Operating Environment (MOE), Chemical Computing Group Inc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1016\/j.bmcl.2013.08.019","article-title":"Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I., II, IX and XII","volume":"23","author":"Biswas","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/23\/7074\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:34:42Z","timestamp":1760168082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/23\/7074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":55,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["molecules26237074"],"URL":"https:\/\/doi.org\/10.3390\/molecules26237074","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}