{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:43:39Z","timestamp":1767905019470,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 108-2320-B-039-041-MY3"],"award-info":[{"award-number":["MOST 108-2320-B-039-041-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","award":["CMU109-MF-20"],"award-info":[{"award-number":["CMU109-MF-20"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-108-146"],"award-info":[{"award-number":["DMR-108-146"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Breast cancer resistance protein (BCRP), one of the ATP-binding cassette (ABC) transporters, was associated with the multidrug resistance (MDR) of chemotherapy. Magnolol (MN) and honokiol (HK) are major bioactive polyphenols of Magnolia officinalis. This study investigated the effects of MN and HK on the function and expression of BCRP for the purpose of developing BCRP inhibitor to overcome MDR. Cell lines including MDCKII-BCRP and MDCKII-WT were used for evaluating the function and expression of BCRP. The results showed that MN (100\u201312.5 \u00b5M) and HK (100\u201312.5 \u00b5M) significantly decreased the function of BCRP by 80~12% and 67~14%, respectively. In addition, MN and HK were verified as substrates of BCRP. Furthermore, MN and HK reduced the protein expression of BCRP, and inhibited the phosphorylation of epidermal growth factor receptor (EGFR) and phosphatidylinositol 3-kinase (PI3K). In conclusion, both MN and HK decreased the function and expression of BCRP via EGFR\/PI3K signaling pathway. Therefore, both compounds were promising candidates for reversing the MDR of chemotherapy.<\/jats:p>","DOI":"10.3390\/molecules26237390","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T22:18:42Z","timestamp":1638829122000},"page":"7390","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration"],"prefix":"10.3390","volume":"26","author":[{"given":"Chung-Ping","family":"Yu","sequence":"first","affiliation":[{"name":"School of Pharmacy, College of Pharmacy, China Medical University, Taichung 406040, Taiwan"},{"name":"Department of Pharmacy, China Medical University Hospital, Taichung 404332, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Ying","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy, China Medical University, Taichung 406040, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy, China Medical University, Taichung 406040, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiuan-Pey","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy, China Medical University, Taichung 406040, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chi","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy, China Medical University, Taichung 406040, Taiwan"},{"name":"Department of Pharmacy, China Medical University Hospital, Taichung 404332, Taiwan"},{"name":"College of Medical and Health Science, Asia University, Taichung 41354, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-60761-416-6_4","article-title":"Mechanisms of multidrug resistance in cancer","volume":"596","author":"Gillet","year":"2010","journal-title":"Methods Mol. 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